SCOPe 2.08: Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases

Lineage for Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (27 families)
   division into families based on beta-sheet topologies

Families:

1. c.37.1.1: Nucleotide and nucleoside kinases [52541] (21 proteins)
   parallel beta-sheet of 5 strands, order 23145

2. c.37.1.2: Shikimate kinase (AroK) [52566] (2 proteins)
   similar to the nucleotide/nucleoside kinases but acts on different substrate
   automatically mapped to Pfam PF01202

3. c.37.1.3: Chloramphenicol phosphotransferase [52569] (1 protein)
   similar to the nucleotide/nucleoside kinases but acts on different substrate
   automatically mapped to Pfam PF07931

4. c.37.1.4: Adenosine-5'phosphosulfate kinase (APS kinase) [52572] (2 proteins)
   automatically mapped to Pfam PF01583

5. c.37.1.5: PAPS sulfotransferase [52575] (15 proteins)
   Pfam PF00685
   similar to the nucleotide/nucleoside kinases but transfer sulphate group

6. c.37.1.6: Phosphoribulokinase/pantothenate kinase [52584] (6 proteins)

7. c.37.1.7: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain [52589] (1 protein)
   automatically mapped to Pfam PF01591

8. c.37.1.8: G proteins [52592] (81 proteins)
   core: mixed beta-sheet of 6 strands, order 231456; strand 2 is antiparallel to the rest

9. c.37.1.9: Motor proteins [52641] (5 proteins)

10. c.37.1.10: Nitrogenase iron protein-like [52652] (16 proteins)
    core: parallel beta-sheet of 7 strands; order 3241567

11. c.37.1.11: RecA protein-like (ATPase-domain) [52670] (22 proteins)
    core: mixed beta-sheet of 8 strands, order 32451678; strand 7 is antiparallel to the rest

12. c.37.1.12: ABC transporter ATPase domain-like [52686] (25 proteins)
    there are two additional subdomains inserted into the central core that has a RecA-like topology
    missing some secondary structures that made up less than one-third of the common domain
    

13. c.37.1.14: RNA helicase [52724] (7 proteins)
    duplication: consists of two similar domains, one binds NTP and the other binds RNA; also contains an all-alpha subdomain in the C-terminal extension

14. c.37.1.15: ATP sulfurylase C-terminal domain [64011] (1 protein)

15. c.37.1.16: Helicase-like domain of reverse gyrase [69496] (1 protein)

16. c.37.1.17: Gluconate kinase [75195] (1 protein)
    similar to the nucleotide/nucleoside kinases
    automatically mapped to Pfam PF01202

17. c.37.1.18: YjeE-like [75213] (1 protein)
    mixed beta-sheet; order 234156(0), strands 2 and 6 are antiparallel to the rest
    automatically mapped to Pfam PF02367

18. c.37.1.19: Tandem AAA-ATPase domain [81268] (41 proteins)
    duplication: tandem repeat of two RecA-like (AAA) domains

19. c.37.1.20: Extended AAA-ATPase domain [81269] (43 proteins)
    fold is similar to that of RecA, but lacks the last two strands, followed by a family-specific Arg-finger domain

20. c.37.1.21: Plasmid maintenance system epsilon/zeta, toxin zeta subunit [82395] (2 proteins)
    similar to the nucleotide/nucleoside kinases; extra N- and C-terminal structures

21. c.37.1.22: Bacterial cell division inhibitor SulA [89678] (1 protein)
    homologous to RecA but lacks its P-loop motif; the fold is C-terminally truncated; 5-stranded parallel beta-sheet, order: 15423

22. c.37.1.23: DNA helicase UvsW [102396] (1 protein)
    contains extra N-terminal alpha+beta subdomain

23. c.37.1.24: Type II thymidine kinase [117558] (2 proteins)
    N-terminal part of Pfam PF00265; parallel beta-sheet of 6 strands, order 324516; topological similarity to the RecA-like proteins, especially CobA (52684)

24. c.37.1.25: Atu3015-like [142332] (2 proteins)
    unknown function; similar to the nucleotide/nucleoside kinases

25. c.37.1.26: Adenosine phosphateisopentenyltransferase (IPT)-like [310655] (1 protein)

26. c.37.1.27: AAA domain of minichromosome maintenance protein (MCM) [418849] (7 proteins)
    contains additional MCM-specific beta hairpin described in PubMed 19073923
    Pfam PF17855

27. c.37.1.0: automated matches [191323] (1 protein)
    not a true family

More info for Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases

Timeline for Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases:

• Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases first appeared (with stable ids) in SCOP 1.55, called Superfamily c.37.1: P-loop containing nucleotide triphosphate hydrolases
  
• Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases appears in SCOPe 2.07