SCOPe 2.08: Protein: Methylenetetrahydrofolate reductase

Lineage for Protein: Methylenetetrahydrofolate reductase

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites

Superfamily c.1.23: FAD-linked oxidoreductase [51730] (3 families)

distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation

Family c.1.23.1: Methylenetetrahydrofolate reductase [51731] (2 proteins)
automatically mapped to Pfam PF02219
Protein Methylenetetrahydrofolate reductase [51732] (2 species)

Species:

Escherichia coli [TaxId:562] [51733] (7 PDB entries)
1. Domains for 1b5t:
  1. Domain d1b5ta_: 1b5t A: [29676]
    complexed with fad, hg
  2. Domain d1b5tb_: 1b5t B: [29677]
    complexed with fad, hg
  3. Domain d1b5tc_: 1b5t C: [29678]
    complexed with fad, hg
2. Domains for 1zp3:
  1. Domain d1zp3a_: 1zp3 A: [203352]
    automated match to d1b5tb_
    complexed with fad, mpd, so4
  2. Domain d1zp3b_: 1zp3 B: [203353]
    automated match to d1b5tb_
    complexed with fad, mpd, so4
  3. Domain d1zp3c_: 1zp3 C: [203354]
    automated match to d1b5tb_
    complexed with fad, mpd, so4
3. Domains for 1zp4:
  1. Domain d1zp4a_: 1zp4 A: [203355]
    automated match to d1b5tb_
    complexed with c2f, fad, so4; mutant
  2. Domain d1zp4b_: 1zp4 B: [203356]
    automated match to d1b5tb_
    complexed with c2f, fad, so4; mutant
  3. Domain d1zp4c_: 1zp4 C: [203357]
    automated match to d1b5tb_
    complexed with c2f, fad, so4; mutant
4. Domains for 1zpt:
  1. Domain d1zpta_: 1zpt A: [203358]
    automated match to d1b5tb_
    complexed with fad, nai, so4
  2. Domain d1zptb_: 1zpt B: [203359]
    automated match to d1b5tb_
    complexed with fad, nai, so4
  3. Domain d1zptc_: 1zpt C: [203360]
    automated match to d1b5tb_
    complexed with fad, nai, so4
5. Domains for 1zrq:
  1. Domain d1zrqa_: 1zrq A: [203361]
    automated match to d1b5tb_
    complexed with fad, nai, so4
  2. Domain d1zrqb_: 1zrq B: [203362]
    automated match to d1b5tb_
    complexed with fad, nai, so4
  3. Domain d1zrqc_: 1zrq C: [203363]
    automated match to d1b5tb_
    complexed with fad, nai, so4
6. Domains for 2fmn:
  1. Domain d2fmna_: 2fmn A: [204229]
    automated match to d1b5tb_
    complexed with 4hf, fad; mutant
  2. Domain d2fmnb_: 2fmn B: [204230]
    automated match to d1b5tb_
    complexed with 4hf, fad; mutant
  3. Domain d2fmnc_: 2fmn C: [204231]
    automated match to d1b5tb_
    complexed with 4hf, fad; mutant
7. Domains for 2fmo:
  1. Domain d2fmoa_: 2fmo A: [204232]
    automated match to d1b5tb_
    complexed with fad, mpd, so4; mutant
  2. Domain d2fmob_: 2fmo B: [204233]
    automated match to d1b5tb_
    complexed with fad, mpd, so4; mutant
  3. Domain d2fmoc_: 2fmo C: [204234]
    automated match to d1b5tb_
    complexed with fad, mpd, so4; mutant
Thermus thermophilus [TaxId:274] [102106] (1 PDB entry)
- Domain for 1v93:
  - Domain d1v93a_: 1v93 A: [100532]
    complexed with dio, fad

More info for Protein Methylenetetrahydrofolate reductase from c.1.23.1: Methylenetetrahydrofolate reductase

Timeline for Protein Methylenetetrahydrofolate reductase from c.1.23.1: Methylenetetrahydrofolate reductase:

Protein Methylenetetrahydrofolate reductase from c.1.23.1: Methylenetetrahydrofolate reductase first appeared (with stable ids) in SCOP 1.55
Protein Methylenetetrahydrofolate reductase from c.1.23.1: Methylenetetrahydrofolate reductase appears in SCOPe 2.07