Lineage for Species: Thermus thermophilus [TaxId: 274]

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies) contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678 the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.23: FAD-linked oxidoreductase [51730] (3 families) distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation

5. Family c.1.23.1: Methylenetetrahydrofolate reductase [51731] (2 proteins) automatically mapped to Pfam PF02219

6. Protein Methylenetetrahydrofolate reductase [51732] (2 species)

7. Species Thermus thermophilus [TaxId:274] [102106] (1 PDB entry)