SCOPe 2.08: Domain d1zrqc_: 1zrq C:

Lineage for d1zrqc_ (1zrq C:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.23: FAD-linked oxidoreductase [51730] (3 families)
   distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation

5. Family c.1.23.1: Methylenetetrahydrofolate reductase [51731] (2 proteins)
   automatically mapped to Pfam PF02219

6. Protein Methylenetetrahydrofolate reductase [51732] (2 species)

7. Species Escherichia coli [TaxId:562] [51733] (7 PDB entries)

8. Domain d1zrqc_: 1zrq C: [203363]
   automated match to d1b5tb_
   complexed with fad, nai, so4

Details for d1zrqc_

PDB Entry: 1zrq, 2.2 Å

PDB Description: escherichia coli methylenetetrahydrofolate reductase (reduced) complexed with nadh, ph 6.0

PDB Compounds: (C:) 5,10-Methylenetetrahydrofolate reductase

SCOPe Domain Sequences for d1zrqc_:

Sequence, based on SEQRES records:

>d1zrqc_ c.1.23.1 (C:) Methylenetetrahydrofolate reductase {Escherichia coli [TaxId: 562]}
qinvsfeffpprtsemeqtlwnsidrlsslkpkfvsvtygansgerdrthsiikgikdrt
gleaaphltcidatpdelrtiardywnngirhivalrgdlppgsgkpemyasdlvtllke
vadfdisvaaypevhpeaksaqadllnlkrkvdaganraitqfffdvesylrfrdrcvsa
gidveiipgilpvsnfkqakkfadmtnvripawmaqmfdgldddaetrklvganiamdmv
kilsregvkdfhfytlnraemsyaichtlgvrp

Sequence, based on observed residues (ATOM records):

>d1zrqc_ c.1.23.1 (C:) Methylenetetrahydrofolate reductase {Escherichia coli [TaxId: 562]}
qinvsfeffpprtsemeqtlwnsidrlsslkpkfvsvtygansgerdrthsiikgikdrt
gleaaphltcidatpdelrtiardywnngirhivalrgdlppemyasdlvtllkevadfd
isvaaypevhpeaksaqadllnlkrkvdaganraitqfffdvesylrfrdrcvsagidve
iipgilpvsnfkqakkfadmtnvripawmaqmfdgldddaetrklvganiamdmvkilsr
egvkdfhfytlnraemsyaichtlgvrp

Timeline for d1zrqc_:

• d1zrqc_ first appeared in SCOPe 2.03
  
• d1zrqc_ appears in SCOPe 2.07