SCOPe 2.08: Domain d1b5tc_: 1b5t C:

Lineage for d1b5tc_ (1b5t C:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.23: FAD-linked oxidoreductase [51730] (3 families)
   distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation

5. Family c.1.23.1: Methylenetetrahydrofolate reductase [51731] (2 proteins)
   automatically mapped to Pfam PF02219

6. Protein Methylenetetrahydrofolate reductase [51732] (2 species)

7. Species Escherichia coli [TaxId:562] [51733] (7 PDB entries)

8. Domain d1b5tc_: 1b5t C: [29678]
   complexed with fad, hg

Details for d1b5tc_

PDB Entry: 1b5t, 2.5 Å

PDB Description: escherichia coli methylenetetrahydrofolate reductase

PDB Compounds: (C:) protein (methylenetetrahydrofolate reductase)

SCOPe Domain Sequences for d1b5tc_:

Sequence, based on SEQRES records:

>d1b5tc_ c.1.23.1 (C:) Methylenetetrahydrofolate reductase {Escherichia coli [TaxId: 562]}
qinvsfeffpprtsemeqtlwnsidrlsslkpkfvsvtygansgerdrthsiikgikdrt
gleaaphltcidatpdelrtiardywnngirhivalrgdlppgsgkpemyasdlvtllke
vadfdisvaaypevhpeaksaqadllnlkrkvdaganraitqfffdvesylrfrdrcvsa
gidveiipgilpvsnfkqakkfadmtnvripawmaqmfdgldddaetrklvganiamdmv
kilsregvkdfhfytlnraemsyaichtlgvrpa

Sequence, based on observed residues (ATOM records):

>d1b5tc_ c.1.23.1 (C:) Methylenetetrahydrofolate reductase {Escherichia coli [TaxId: 562]}
qinvsfeffpprtsemeqtlwnsidrlsslkpkfvsvtygansgerdrthsiikgikdrt
gleaaphltcidatpdelrtiardywnngirhivalrgdlppyasdlvtllkevadfdis
vaaypevhpeaksaqadllnlkrkvdaganraitqfffdvesylrfrdrcvsagidveii
pgilpvsnfkqakkfadmtnvripawmaqmfdgldddaetrklvganiamdmvkilsreg
vkdfhfytlnraemsyaichtlgvrpa

Timeline for d1b5tc_:

• d1b5tc_ first appeared (with stable ids) in SCOP 1.55
  
• d1b5tc_ appears in SCOPe 2.07