SCOPe 2.08: Superfamily c.1.23: FAD-linked oxidoreductase

Lineage for Superfamily c.1.23: FAD-linked oxidoreductase

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (34 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.23: FAD-linked oxidoreductase [51730] (3 families)
   distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation

Families:

1. c.1.23.1: Methylenetetrahydrofolate reductase [51731] (2 proteins)
   automatically mapped to Pfam PF02219

2. c.1.23.2: Proline dehydrohenase domain of bifunctional PutA protein [82279] (2 proteins)
   automatically mapped to Pfam PF01619

3. c.1.23.0: automated matches [350759] (1 protein)
   not a true family

More info for Superfamily c.1.23: FAD-linked oxidoreductase

Timeline for Superfamily c.1.23: FAD-linked oxidoreductase:

• Superfamily c.1.23: FAD-linked oxidoreductase first appeared (with stable ids) in SCOP 1.55, called Superfamily c.1.23: Methylenetetrahydrofolate reductase
  
• Superfamily c.1.23: FAD-linked oxidoreductase appears in SCOPe 2.07