SCOPe 2.08: Domain d1z6zd2: 1z6z D:2-258

Lineage for d1z6zd2 (1z6z D:2-258)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein Sepiapterin reductase [51767] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [141874] (14 PDB entries)
   Uniprot P35270 5-261

8. Domain d1z6zd2: 1z6z D:2-258 [124578]
   Other proteins in same PDB: d1z6za2, d1z6zb3, d1z6zc3, d1z6zd3, d1z6ze3, d1z6zf3
   automated match to d1z6za1
   complexed with cl, nap, so4

Details for d1z6zd2

PDB Entry: 1z6z, 2.5 Å

PDB Description: crystal structure of human sepiapterin reductase in complex with nadp+

PDB Compounds: (D:) sepiapterin reductase

SCOPe Domain Sequences for d1z6zd2:

Sequence, based on SEQRES records:

>d1z6zd2 c.2.1.2 (D:2-258) Sepiapterin reductase {Human (Homo sapiens) [TaxId: 9606]}
lgravclltgasrgfgrtlapllasllspgsvlvlsarndealrqleaelgaersglrvv
rvpadlgaeaglqqllgalrelprpkglqrlllinnagslgdvskgfvdlsdstqvnnyw
alnltsmlcltssvlkafpdspglnrtvvnisslcalqpfkgwalycagkaardmlfqvl
aleepnvrvlnyapgpldtdmqqlaretsvdpdmrkglqelkakgklvdckvsaqkllsl
lekdefksgahvdfydk

Sequence, based on observed residues (ATOM records):

>d1z6zd2 c.2.1.2 (D:2-258) Sepiapterin reductase {Human (Homo sapiens) [TaxId: 9606]}
lgravclltgasrgfgrtlapllasllspgsvlvlsarndealrqleaellrvvrvpadl
gaeaglqqllgalrelprpkglqrlllinnagslgdvskgfvdlsdstqvnnywalnlts
mlcltssvlkafpdspglnrtvvnisslcalqpfkgwalycagkaardmlfqvlaleepn
vrvlnyapgpldtdmqqlaretsvdpdmrkglqelkakgklvdckvsaqkllsllekdef
ksgahvdfydk

Timeline for d1z6zd2:

• d1z6zd2 first appeared in SCOP 1.73, called d1z6zd1
  
• d1z6zd2 appears in SCOPe 2.07