SCOPe 2.08: Protein: Sepiapterin reductase

Lineage for Protein: Sepiapterin reductase

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
has additional subdomain(s) that are not in the common domain

Protein Sepiapterin reductase [51767] (2 species)

Species:

Human (Homo sapiens) [TaxId:9606] [141874] (14 PDB entries)
Uniprot P35270 5-261
1. Domains for 1z6z:
  1. Domain d1z6za1: 1z6z A:2-258 [124575]
    Other proteins in same PDB: d1z6za2, d1z6zb3, d1z6zc3, d1z6zd3, d1z6ze3, d1z6zf3
    complexed with cl, nap, so4
  2. Domain d1z6zb2: 1z6z B:2-258 [124576]
    Other proteins in same PDB: d1z6za2, d1z6zb3, d1z6zc3, d1z6zd3, d1z6ze3, d1z6zf3
    automated match to d1z6za1
    complexed with cl, nap, so4
  3. Domain d1z6zc2: 1z6z C:2-258 [124577]
    Other proteins in same PDB: d1z6za2, d1z6zb3, d1z6zc3, d1z6zd3, d1z6ze3, d1z6zf3
    automated match to d1z6za1
    complexed with cl, nap, so4
  4. Domain d1z6zd2: 1z6z D:2-258 [124578]
    Other proteins in same PDB: d1z6za2, d1z6zb3, d1z6zc3, d1z6zd3, d1z6ze3, d1z6zf3
    automated match to d1z6za1
    complexed with cl, nap, so4
  5. Domain d1z6ze2: 1z6z E:2-258 [124579]
    Other proteins in same PDB: d1z6za2, d1z6zb3, d1z6zc3, d1z6zd3, d1z6ze3, d1z6zf3
    automated match to d1z6za1
    complexed with cl, nap, so4
  6. Domain d1z6zf2: 1z6z F:2-258 [124580]
    Other proteins in same PDB: d1z6za2, d1z6zb3, d1z6zc3, d1z6zd3, d1z6ze3, d1z6zf3
    automated match to d1z6za1
    complexed with cl, nap, so4
2. Domains for 4hwk:
  1. Domain d4hwka_: 4hwk A: [252530]
    automated match to d1z6za1
    complexed with gol, nap, peg, sfy, so4
  2. Domain d4hwkb_: 4hwk B: [252531]
    automated match to d1z6za1
    complexed with gol, nap, peg, sfy, so4
  3. Domain d4hwkc_: 4hwk C: [252532]
    automated match to d1z6za1
    complexed with gol, nap, peg, sfy, so4
  4. Domain d4hwkd_: 4hwk D: [252533]
    automated match to d1z6za1
    complexed with gol, nap, peg, sfy, so4
3. Domains for 4j7u:
  1. Domain d4j7ua_: 4j7u A: [252835]
    automated match to d1z6za1
    complexed with gol, nap, peg, so4, ytz
  2. Domain d4j7ub_: 4j7u B: [252836]
    automated match to d1z6za1
    complexed with gol, nap, peg, so4, ytz
  3. Domain d4j7uc_: 4j7u C: [252837]
    automated match to d1z6za1
    complexed with gol, nap, peg, so4, ytz
  4. Domain d4j7ud_: 4j7u D: [252838]
    automated match to d1z6za1
    complexed with gol, nap, peg, so4, ytz
4. Domains for 4j7x:
  1. Domain d4j7xa_: 4j7x A: [252839]
    automated match to d1z6za1
    complexed with gol, nap, peg, sas, so4
  2. Domain d4j7xb_: 4j7x B: [252840]
    automated match to d1z6za1
    complexed with gol, nap, peg, sas, so4
  3. Domain d4j7xf_: 4j7x F: [252841]
    automated match to d1z6za1
    complexed with gol, nap, peg, sas, so4
  4. Domain d4j7xj_: 4j7x J: [252842]
    automated match to d1z6za1
    complexed with gol, nap, peg, sas, so4
5. Domains for 4xwy:
  1. Domain d4xwya_: 4xwy A: [274553]
    automated match to d1z6zb_
    complexed with 43o, ndp, so4
  2. Domain d4xwyb_: 4xwy B: [274554]
    automated match to d1z6zb_
    complexed with 43o, ndp, so4
  3. Domain d4xwyc_: 4xwy C: [274555]
    automated match to d1z6zb_
    complexed with 43o, ndp, so4
  4. Domain d4xwyd_: 4xwy D: [274556]
    automated match to d1z6zb_
    complexed with 43o, ndp, so4
6. Domains for 4z3k:
  1. Domain d4z3ka_: 4z3k A: [279521]
    automated match to d1z6zb_
    complexed with 4kl, edo, nap, so4
  2. Domain d4z3kb_: 4z3k B: [279520]
    automated match to d1z6zb_
    complexed with 4kl, edo, nap, so4
  3. Domain d4z3kc_: 4z3k C: [279518]
    automated match to d1z6zb_
    complexed with 4kl, edo, nap, so4
  4. Domain d4z3kd_: 4z3k D: [279519]
    automated match to d1z6zb_
    complexed with 4kl, edo, nap, so4
7. Domains for 6i6c:
  1. Domain d6i6ca1: 6i6c A:1-260 [370262]
    Other proteins in same PDB: d6i6ca2
    automated match to d4hwka_
    complexed with edo, h4h, nap
  2. Domain d6i6cb_: 6i6c B: [370244]
    Other proteins in same PDB: d6i6ca2
    automated match to d4hwka_
    complexed with edo, h4h, nap
8. Domains for 6i6f:
  1. Domain d6i6fa1: 6i6f A:1-260 [370224]
    Other proteins in same PDB: d6i6fa2
    automated match to d4hwka_
    complexed with edo, h4e, nap
  2. Domain d6i6fb_: 6i6f B: [370260]
    Other proteins in same PDB: d6i6fa2
    automated match to d4hwka_
    complexed with edo, h4e, nap
9. Domains for 6i6p:
  1. Domain d6i6pa1: 6i6p A:1-261 [370239]
    Other proteins in same PDB: d6i6pa2
    automated match to d4hwka_
    complexed with edo, h4t, nap
  2. Domain d6i6pb_: 6i6p B: [370270]
    Other proteins in same PDB: d6i6pa2
    automated match to d4hwka_
    complexed with edo, h4t, nap
10. Domains for 6i6t:
  1. Domain d6i6ta_: 6i6t A: [370261]
    automated match to d4hwka_
    complexed with edo, h5b, nap
  2. Domain d6i6tb_: 6i6t B: [370193]
    automated match to d4hwka_
    complexed with edo, h5b, nap
11. Domains for 6i6v:
  1. Domain d6i6va1: 6i6v A:1-260 [370204]
    Other proteins in same PDB: d6i6va2
    automated match to d4hwka_
    complexed with edo, h6e, nap
  2. Domain d6i6vb_: 6i6v B: [370191]
    Other proteins in same PDB: d6i6va2
    automated match to d4hwka_
    complexed with edo, h6e, nap
12. Domains for 6i79:
  1. Domain d6i79a1: 6i79 A:1-261 [370254]
    Other proteins in same PDB: d6i79a2, d6i79b2
    automated match to d4hwka_
    complexed with h5e, nap
  2. Domain d6i79b1: 6i79 B:1-261 [370281]
    Other proteins in same PDB: d6i79a2, d6i79b2
    automated match to d4hwka_
    complexed with h5e, nap
13. Domains for 6usn:
  1. Domain d6usna_: 6usn A: [378166]
    automated match to d4hwka_
    complexed with gol, nap, peg, qgv, so4
  2. Domain d6usnb_: 6usn B: [378155]
    automated match to d4hwka_
    complexed with gol, nap, peg, qgv, so4
  3. Domain d6usnc_: 6usn C: [378145]
    automated match to d4hwka_
    complexed with gol, nap, peg, qgv, so4
  4. Domain d6usnd_: 6usn D: [378146]
    automated match to d4hwka_
    complexed with gol, nap, peg, qgv, so4
14. Domains for 7dsf:
  1. Domain d7dsfa_: 7dsf A: [398920]
    automated match to d4hwka_
    complexed with act, nap, zn
  2. Domain d7dsfb_: 7dsf B: [398955]
    automated match to d4hwka_
    complexed with act, nap, zn
Mouse (Mus musculus) [TaxId:10090] [51768] (3 PDB entries)
1. Domain for 1nas:
  - Domain d1nasa_: 1nas A: [29831]
    complexed with ase, nap, oaa
2. Domain for 1oaa:
  - Domain d1oaaa_: 1oaa A: [29829]
    complexed with nap, oaa, so4
3. Domain for 1sep:
  - Domain d1sepa_: 1sep A: [29830]
    complexed with bio, nap

More info for Protein Sepiapterin reductase from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein Sepiapterin reductase from c.2.1.2: Tyrosine-dependent oxidoreductases:

Protein Sepiapterin reductase from c.2.1.2: Tyrosine-dependent oxidoreductases first appeared (with stable ids) in SCOP 1.55
Protein Sepiapterin reductase from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOPe 2.07