Lineage for Family b.1.1.2: C1 set domains (antibody constant domain-like)

  1. Root: SCOP 1.65
  2. 287094Class b: All beta proteins [48724] (126 folds)
  3. 287095Fold b.1: Immunoglobulin-like beta-sandwich [48725] (20 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 287096Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 288543Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (22 proteins)

Proteins:

  1. 288544beta2-microglobulin [88600] (4 species)
    1. 288545Species Cow (Bos taurus) [TaxId:9913] [48946] (1 PDB entry)
    2. 288547Species Human (Homo sapiens) [TaxId:9606] [88602] (67 PDB entries)
    3. 288646Species Mouse (Mus musculus) [TaxId:10090] [88603] (48 PDB entries)
    4. 288719Species Rat (Rattus norvegicus) [TaxId:10116] [88601] (6 PDB entries)
  2. 288729CD1, alpha-3 domain [88615] (2 species)
    1. 288730Species Human (Homo sapiens), CD1b [TaxId:9606] [88617] (2 PDB entries)
    2. 288733Species Mouse (Mus musculus) [TaxId:10090] [88616] (1 PDB entry)
  3. 288736Class I MHC homolog, alpha-3 domain [88610] (3 species)
    gamma, delta T-cell ligand
    1. 288737Species Human (Homo sapiens), Mic-a [TaxId:9606] [48968] (2 PDB entries)
    2. 288740Species Human (Homo sapiens), Mic-b [TaxId:9606] [74826] (1 PDB entry)
    3. 288742Species Mouse (Mus musculus), t22 [TaxId:10090] [88611] (1 PDB entry)
  4. 288747Class I MHC, alpha-3 domain [88604] (3 species)
    1. 288748Species Human (Homo sapiens) [TaxId:9606] [88605] (56 PDB entries)
    2. 288830Species Mouse (Mus musculus) [TaxId:10090] [88606] (49 PDB entries)
    3. 288903Species Rat (Rattus norvegicus), RT1-AA [TaxId:10116] [88607] (3 PDB entries)
  5. 288908Class II MHC alpha chain, C-terminal domain [88618] (6 species)
    1. 288909Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88619] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 288911Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88623] (1 PDB entry)
      probably orthologous to the mouse I-A group
    3. 288913Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88621] (23 PDB entries)
      probably orthologous to the mouse I-E group
    4. 288945Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88620] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 288947Species Mouse (Mus musculus), I-A group [TaxId:10090] [88624] (10 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 288963Species Mouse (Mus musculus), I-E group [TaxId:10090] [88622] (7 PDB entries)
      probably orthologous to the human HLA-DR group
  6. 288980Class II MHC beta chain, C-terminal domain [88625] (6 species)
    1. 288981Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88626] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 288983Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88630] (1 PDB entry)
      probably orthologous to the mouse I-A group
    3. 288985Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88628] (23 PDB entries)
      probably orthologous to the mouse I-E group
    4. 289017Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88627] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 289019Species Mouse (Mus musculus), I-A group [TaxId:10090] [88631] (10 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 289035Species Mouse (Mus musculus), I-E group [TaxId:10090] [88629] (7 PDB entries)
      probably orthologous to the human HLA-DR group
  7. 289052Fc (IgG) receptor, alpha-3 domain [88612] (2 species)
    1. 289053Species Human (Homo sapiens) [TaxId:9606] [88614] (1 PDB entry)
    2. 289055Species Rat (Rattus norvegicus) [TaxId:10116] [88613] (3 PDB entries)
  8. 289061Hemochromatosis protein Hfe, alpha-3 domain [88608] (1 species)
  9. 289068Immunoglobulin heavy chain alpha constant domain 1, CH1-alpha [88580] (1 species)
  10. 289073Immunoglobulin heavy chain alpha constant domain 2, CH2-alpha [89181] (1 species)
  11. 289077Immunoglobulin heavy chain alpha constant domain 3, CH3-alpha [89183] (1 species)
  12. 289081Immunoglobulin heavy chain epsilon constant domain 2, CH2-epsilon [88594] (1 species)
  13. 289086Immunoglobulin heavy chain epsilon constant domain 3, CH3-epsilon [88596] (1 species)
  14. 289093Immunoglobulin heavy chain epsilon constant domain 4, CH4-epsilon [88598] (1 species)
  15. 289100Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (5 species)
    1. 289101Species Hamster (Cricetulus griseus) [TaxId:10029] [88579] (1 PDB entry)
    2. 289104Species Human (Homo sapiens) [TaxId:9606] [88575] (63 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
    3. 289192Species Mouse (Mus musculus) [TaxId:10090] [88576] (237 PDB entries)
    4. 289493Species Mouse (Mus musculus), gamma3 [TaxId:10090] [88577] (5 PDB entries)
    5. 289500Species Rat (Rattus norvegicus) [TaxId:10116] [88578] (4 PDB entries)
  16. 289511Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma [88584] (4 species)
    1. 289512Species Human (Homo sapiens) [TaxId:9606] [88585] (19 PDB entries)
    2. 289544Species Mouse (Mus musculus) [TaxId:10090] [88586] (1 PDB entry)
    3. 289547Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88587] (1 PDB entry)
    4. 289550Species Rat (Rattus norvegicus) [TaxId:10116] [88588] (2 PDB entries)
  17. 289555Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma [88589] (5 species)
    1. 289556Species Guinea pig (Cavia porcellus) [TaxId:10141] [49123] (1 PDB entry)
    2. 289558Species Human (Homo sapiens) [TaxId:9606] [88590] (19 PDB entries)
    3. 289590Species Mouse (Mus musculus) [TaxId:10090] [88591] (2 PDB entries)
    4. 289595Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88592] (1 PDB entry)
    5. 289598Species Rat (Rattus norvegicus) [TaxId:10116] [88593] (2 PDB entries)
  18. 289603Immunoglobulin heavy chain mu constant domain 1, CH1-mu [88582] (1 species)
  19. 289615Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (3 species)
    1. 289616Species Human (Homo sapiens) [TaxId:9606] [88569] (62 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
    2. 289708Species Mouse (Mus musculus) [TaxId:10090] [88567] (225 PDB entries)
    3. 289993Species Rat (Rattus norvegicus) [TaxId:10116] [88568] (4 PDB entries)
  20. 290004Immunoglobulin light chain lambda constant domain, CL-lambda [88570] (3 species)
    1. 290005Species Hamster (Cricetulus griseus) [TaxId:10029] [88573] (1 PDB entry)
    2. 290008Species Human (Homo sapiens) [TaxId:9606] [88572] (33 PDB entries)
    3. 290069Species Mouse (Mus musculus) [TaxId:10090] [88571] (20 PDB entries)
  21. 290095T-cell antigen receptor [49125] (6 species)
    1. 290096Species Human (Homo sapiens), alpha-chain [TaxId:9606] [49127] (9 PDB entries)
    2. 290106Species Human (Homo sapiens), beta-chain [TaxId:9606] [49129] (11 PDB entries)
    3. 290119Species Human (Homo sapiens), delta-chain [TaxId:9606] [63662] (1 PDB entry)
    4. 290124Species Human (Homo sapiens), gamma-chain [TaxId:9606] [63661] (1 PDB entry)
    5. 290129Species Mouse (Mus musculus), alpha-chain [TaxId:10090] [49126] (5 PDB entries)
    6. 290139Species Mouse (Mus musculus), beta-chain [TaxId:10090] [49128] (10 PDB entries)
  22. 290158Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain [48965] (1 species)
    fat depleting factor related to class I MHC

More info for Family b.1.1.2: C1 set domains (antibody constant domain-like)

Timeline for Family b.1.1.2: C1 set domains (antibody constant domain-like):