SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family b.1.1.2: C1 set domains (antibody constant domain-like)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2017116Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2020524Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 protein domains)

Protein Domains:

  1. 2020525beta2-microglobulin [88600] (5 species)
    1. 2020526Species Cow (Bos taurus) [TaxId:9913] [48946] (6 PDB entries)
    2. 2020537Species Human (Homo sapiens) [TaxId:9606] [88602] (418 PDB entries)
      Uniprot P61769 21-119 ! Uniprot P01884
    3. 2021164Species Mouse (Mus musculus) [TaxId:10090] [88603] (175 PDB entries)
      Uniprot P01887
    4. 2021437Species Norway rat (Rattus norvegicus) [TaxId:10116] [88601] (6 PDB entries)
    5. 2021447Species Pig (Sus scrofa) [TaxId:9823] [189845] (2 PDB entries)
  2. 2021451CD1, alpha-3 domain [88615] (5 species)
    1. 2021452Species Cow (Bos taurus) [TaxId:9913] [226527] (2 PDB entries)
    2. 2021456Species Human (Homo sapiens), CD1a [TaxId:9606] [101513] (5 PDB entries)
    3. 2021466Species Human (Homo sapiens), CD1b [TaxId:9606] [88617] (10 PDB entries)
    4. 2021479Species Human (Homo sapiens), CD1d [TaxId:9606] [158876] (2 PDB entries)
      Uniprot P15813 202-295
    5. 2021483Species Mouse (Mus musculus) [TaxId:10090] [88616] (9 PDB entries)
  3. 2021496Class I MHC homolog, alpha-3 domain [88610] (4 species)
    gamma, delta T-cell ligand
    1. 2021497Species Human (Homo sapiens), Mic-a [TaxId:9606] [48968] (2 PDB entries)
    2. 2021500Species Human (Homo sapiens), Mic-b [TaxId:9606] [74826] (1 PDB entry)
    3. 2021502Species Mouse (Mus musculus), t10 [TaxId:10090] [101512] (1 PDB entry)
    4. 2021507Species Mouse (Mus musculus), t22 [TaxId:10090] [88611] (2 PDB entries)
  4. 2021514Class I MHC, alpha-3 domain [88604] (4 species)
    1. 2021515Species Human (Homo sapiens) [TaxId:9606] [88605] (198 PDB entries)
      Uniprot P30685 25-300 ! Uniprot P30443 25-298 # 1A01_HUMAN HLA class I histocompatibility antigen, A-1 alpha chain precursor ! Uniprot P30481 25-300 ! Uniprot P01892 25-298 ! Uniprot P13746 25-299 # 1A11_HUMAN HLA class I histocompatibility antigen, A-11 alpha chain precursor
    2. 2021804Species Mouse (Mus musculus) [TaxId:10090] [88606] (104 PDB entries)
      Uniprot P01901 22-299
    3. 2021982Species Norway rat (Rattus norvegicus), RT1-AA [TaxId:10116] [88607] (3 PDB entries)
    4. 2021987Species Rhesus monkey (Macaca mulatta) [TaxId:9544] [158875] (1 PDB entry)
  5. 2021990Class II MHC alpha chain, C-terminal domain [88618] (6 species)
    1. 2021991Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88619] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 2021993Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88623] (3 PDB entries)
      probably orthologous to the mouse I-A group
    3. 2021998Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88621] (37 PDB entries)
      Uniprot P01903 28-207
      probably orthologous to the mouse I-E group
    4. 2022054Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88620] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 2022056Species Mouse (Mus musculus), I-A group [TaxId:10090] [88624] (25 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 2022096Species Mouse (Mus musculus), I-E group [TaxId:10090] [88622] (9 PDB entries)
      probably orthologous to the human HLA-DR group
  6. 2022117Class II MHC beta chain, C-terminal domain [88625] (6 species)
    1. 2022118Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88626] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 2022120Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88630] (3 PDB entries)
      probably orthologous to the mouse I-A group
    3. 2022125Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88628] (41 PDB entries)
      Uniprot P04229 30-219
      probably orthologous to the mouse I-E group
    4. 2022186Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88627] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 2022188Species Mouse (Mus musculus), I-A group [TaxId:10090] [88631] (17 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 2022215Species Mouse (Mus musculus), I-E group [TaxId:10090] [88629] (9 PDB entries)
      probably orthologous to the human HLA-DR group
  7. 2022236Fc (IgG) receptor, alpha-3 domain [88612] (2 species)
    1. 2022237Species Human (Homo sapiens) [TaxId:9606] [88614] (1 PDB entry)
    2. 2022239Species Norway rat (Rattus norvegicus) [TaxId:10116] [88613] (3 PDB entries)
  8. 2022245Hemochromatosis protein Hfe, alpha-3 domain [88608] (1 species)
  9. 2022252Immunoglobulin heavy chain alpha constant domain 1, CH1-alpha [88580] (1 species)
  10. 2022257Immunoglobulin heavy chain alpha constant domain 2, CH2-alpha [89181] (1 species)
  11. 2022263Immunoglobulin heavy chain alpha constant domain 3, CH3-alpha [89183] (1 species)
  12. 2022269Immunoglobulin heavy chain epsilon constant domain 2, CH2-epsilon [88594] (1 species)
  13. 2022276Immunoglobulin heavy chain epsilon constant domain 3, CH3-epsilon [88596] (1 species)
  14. 2022285Immunoglobulin heavy chain epsilon constant domain 4, CH4-epsilon [88598] (1 species)
  15. 2022294Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)
    1. 2022295Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [88579] (1 PDB entry)
    2. 2022298Species Human (Homo sapiens) [TaxId:9606] [88575] (179 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
      Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
    3. 2022610Species Mouse (Mus musculus) [TaxId:10090] [88576] (424 PDB entries)
      Uniprot P01864 # GCAB_MOUSE Ig gamma-2A chain C region secreted form (B allele) ! Uniprot P01863 #GCAA_MOUSE Ig gamma-2A chain C region, A allele; 86% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01751 (Ig heavy chain V region B1-8/186-2) and Uniprot P01864 (Ig gamma-2A chain C region secreted form) ! Uniprot P01868 # GC1_MOUSE Ig gamma-1 chain C region secreted form ! Uniprot P01864 # GCAB_MOUSE (P01864) Ig gamma-2A chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! Uniprot P01863 # GCAA_MOUSE Ig gamma-2A chain C region, A allele ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01868 # ! GC1_MOUSE Ig gamma-1 chain C region secreted form
    4. 2023159Species Mouse (Mus musculus), gamma3 [TaxId:10090] [88577] (8 PDB entries)
      Uniprot P22436 # GC3_MOUSE (P22436) Ig gamma-3 chain C region
    5. 2023173Species Norway rat (Rattus norvegicus) [TaxId:10116] [88578] (5 PDB entries)
    6. 2023186Species Synthetic construct [TaxId:32630] [158874] (1 PDB entry)
  16. 2023188Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma [88584] (4 species)
    1. 2023189Species Human (Homo sapiens) [TaxId:9606] [88585] (52 PDB entries)
      Uniprot P01857 #118-327 ! Uniprot P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
    2. 2023270Species Mouse (Mus musculus) [TaxId:10090] [88586] (1 PDB entry)
    3. 2023273Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88587] (1 PDB entry)
    4. 2023276Species Norway rat (Rattus norvegicus) [TaxId:10116] [88588] (3 PDB entries)
  17. 2023282Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma [88589] (5 species)
    1. 2023283Species Guinea pig (Cavia porcellus) [TaxId:10141] [49123] (1 PDB entry)
    2. 2023285Species Human (Homo sapiens) [TaxId:9606] [88590] (63 PDB entries)
      Uniprot P01857 #118-327 ! Uniprot P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
    3. 2023385Species Mouse (Mus musculus) [TaxId:10090] [88591] (2 PDB entries)
    4. 2023390Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88592] (1 PDB entry)
    5. 2023393Species Norway rat (Rattus norvegicus) [TaxId:10116] [88593] (3 PDB entries)
  18. 2023399Immunoglobulin heavy chain mu constant domain 1, CH1-mu [88582] (1 species)
  19. 2023413Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)
    1. 2023414Species Human (Homo sapiens) [TaxId:9606] [88569] (144 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
      SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody
    2. 2023645Species Mouse (Mus musculus) [TaxId:10090] [88567] (355 PDB entries)
      Uniprot P01837# KAC_MOUSE Ig kappa chain C region; 99% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! Uniprot P01837 # KAC_MOUSE Ig kappa chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01837 # ! KAC_MOUSE Ig kappa chain C region
    3. 2024104Species Norway rat (Rattus norvegicus) [TaxId:10116] [88568] (5 PDB entries)
    4. 2024117Species Synthetic construct [TaxId:32630] [158871] (1 PDB entry)
  20. 2024122Immunoglobulin light chain lambda constant domain, CL-lambda [88570] (3 species)
    1. 2024123Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [88573] (1 PDB entry)
    2. 2024126Species Human (Homo sapiens) [TaxId:9606] [88572] (46 PDB entries)
    3. 2024207Species Mouse (Mus musculus) [TaxId:10090] [88571] (21 PDB entries)
      Uniprot Q8N355 20-230 # 94% sequence identity; natural chimera: antibody light chain (Fab HYB3)
  21. 2024235Immunomodulatory protein m144, alpha-3 domain [110048] (1 species)
  22. 2024239T-cell antigen receptor [49125] (7 species)
    1. 2024240Species Human (Homo sapiens), alpha-chain [TaxId:9606] [49127] (24 PDB entries)
    2. 2024270Species Human (Homo sapiens), beta-chain [TaxId:9606] [49129] (29 PDB entries)
    3. 2024313Species Human (Homo sapiens), delta-chain [TaxId:9606] [63662] (2 PDB entries)
    4. 2024320Species Human (Homo sapiens), gamma-chain [TaxId:9606] [63661] (2 PDB entries)
    5. 2024327Species Mouse (Mus musculus) [TaxId:10090] [226194] (2 PDB entries)
    6. 2024330Species Mouse (Mus musculus), alpha-chain [TaxId:10090] [49126] (11 PDB entries)
    7. 2024351Species Mouse (Mus musculus), beta-chain [TaxId:10090] [49128] (15 PDB entries)
  23. 2024380Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain [48965] (1 species)
    fat depleting factor related to class I MHC
  24. 2024392automated matches [190374] (14 species)
    not a true protein
    1. 2024393Species Chimpanzee (Pan troglodytes) [TaxId:9598] [226268] (1 PDB entry)
    2. 2024396Species Cow (Bos taurus) [TaxId:9913] [225911] (1 PDB entry)
    3. 2024401Species Escherichia coli [TaxId:562] [224854] (1 PDB entry)
    4. 2024406Species Human (Homo sapiens) [TaxId:9606] [187221] (624 PDB entries)
    5. 2025378Species Llama glama [TaxId:9844] [271450] (2 PDB entries)
    6. 2025381Species Mouse (Mus musculus) [TaxId:10090] [224855] (477 PDB entries)
    7. 2026069Species Murinae, homo sapiens [TaxId:39107] [228176] (2 PDB entries)
    8. 2026074Species Norway rat (Rattus norvegicus) [TaxId:10116] [262079] (4 PDB entries)
    9. 2026085Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [226687] (4 PDB entries)
    10. 2026089Species Rhesus monkey (Macaca mulatta) [TaxId:9544] [226134] (7 PDB entries)
    11. 2270239Species Other sequences [TaxId:28384] [313544] (1 PDB entry)
    12. 2273847Species Lama glama [TaxId:9844] [317148] (1 PDB entry)
    13. 2283690Species Homo sapiens/mus [TaxId:1383439] [326991] (1 PDB entry)
    14. 2292209Species Dengue virus [TaxId:12637] [335510] (1 PDB entry)

More info for Family b.1.1.2: C1 set domains (antibody constant domain-like)

Timeline for Family b.1.1.2: C1 set domains (antibody constant domain-like):