Lineage for Fold b.1: Immunoglobulin-like beta-sandwich

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands

Superfamilies:

  1. 2017116b.1.1: Immunoglobulin [48726] (5 families) (S)
  2. 2029371b.1.2: Fibronectin type III [49265] (2 families) (S)
  3. 2029998b.1.3: PKD domain [49299] (1 family) (S)
  4. 2030012b.1.4: beta-Galactosidase/glucuronidase domain [49303] (2 families) (S)
  5. 2030723b.1.5: Transglutaminase, two C-terminal domains [49309] (2 families) (S)
    automatically mapped to Pfam PF00927
  6. 2030835b.1.6: Cadherin-like [49313] (3 families) (S)
  7. 2030967b.1.7: Actinoxanthin-like [49319] (1 family) (S)
    automatically mapped to Pfam PF00960
  8. 2031006b.1.8: Cu,Zn superoxide dismutase-like [49329] (2 families) (S)
    has additional strand at N-terminus
  9. 2031615b.1.9: CBD9-like [49344] (4 families) (S)
    has additional strand at N-terminus; the active site in a similar topological location as the Cu,Zn SOD site
  10. 2031643b.1.10: Clathrin adaptor appendage domain [49348] (4 families) (S)
    contains an additional N-terminal strand
  11. 2031706b.1.11: PapD-like [49354] (3 families) (S)
    contains PP switch between strands D and C'
  12. 2031845b.1.12: Purple acid phosphatase, N-terminal domain [49363] (2 families) (S)
  13. 2031889b.1.13: Superoxide reductase-like [49367] (2 families) (S)
  14. 2031983b.1.14: Invasin/intimin cell-adhesion fragments [49373] (2 families) (S)
  15. 2032015b.1.15: Integrin domains [69179] (2 families) (S)
  16. 2032065b.1.16: Lamin A/C globular tail domain [74853] (2 families) (S)
  17. 2032092b.1.17: Thiol:disulfide interchange protein DsbD, N-terminal domain (DsbD-alpha) [74863] (2 families) (S)
  18. 2032114b.1.18: E set domains [81296] (24 families) (S)
    "Early" Ig-like fold families possibly related to the immunoglobulin and/or fibronectin type III superfamilies
  19. 2033306b.1.19: Antigen MPT63/MPB63 (immunoprotective extracellular protein) [81982] (1 family) (S)
    automatically mapped to Pfam PF09167
  20. 2033311b.1.20: Tp47 lipoprotein, middle and C-terminal domains [81986] (1 family) (S)
  21. 2033319b.1.21: Fungal immunomodulatory protein, FIP [101542] (1 family) (S)
    automatically mapped to Pfam PF09259
  22. 2033331b.1.22: ASF1-like [101546] (1 family) (S)
    contains extra C-terminal strand
    automatically mapped to Pfam PF04729
  23. 2033365b.1.23: ApaG-like [110069] (2 families) (S)
  24. 2033381b.1.24: Accessory protein X4 (ORF8, ORF7a) [117066] (1 family) (S)
    automatically mapped to Pfam PF08779
  25. 2033389b.1.25: LEA14-like [117070] (1 family) (S)
  26. 2033394b.1.26: ICP-like [141066] (2 families) (S)
    topological variant with similarity to the Cupredoxin-like fold (49502) in the N-terminal region
  27. 2033415b.1.27: CalX-like [141072] (2 families) (S)
  28. 2033450b.1.28: NEAT domain-like [158911] (2 families) (S)
  29. 2033537b.1.29: Macroglobulin [254121] (8 families) (S)
    C3 MG domains possibly arose by gene duplication according to PubMed 16177781; PubMed 17608619; possibly related to immunoglobulins according to Pfam clan annotations
  30. 2033616b.1.30: Zn aminopeptidase insert domain [254133] (2 families) (S)
    same topology as (b.1.15.1)
  31. 2033676b.1.31: Fibronectin III-like [254143] (2 families) (S)
    Pfam PF14310; PubMed 20138890; unclear if related to Fibronectin type III (b.1.2)
  32. 2033698b.1.32: Sodium/potassium-transporting ATPase, beta subunit extracellular domain [310575] (1 family) (S)
    May be homologous to IL1R (49177), according to PubMed 18075585
  33. 2033719b.1.33: Membrane antigen precursor-like [310605] (2 families) (S)
    Pfam PF10634

More info for Fold b.1: Immunoglobulin-like beta-sandwich

Timeline for Fold b.1: Immunoglobulin-like beta-sandwich: