| Class e: Multi-domain proteins (alpha and beta) [56572] (39 folds) |
| Fold e.3: beta-Lactamase/D-ala carboxypeptidase [56600] (1 superfamily) contains a cluster of helices and an alpha+beta sandwich |
Superfamily e.3.1: beta-Lactamase/D-ala carboxypeptidase [56601] (1 family) ![]() |
| Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase [56602] (9 proteins) |
| Protein beta-Lactamase, class A [56606] (13 species) |
| Bacillus licheniformis [TaxId:1402] [56612] (5 PDB entries) |
| Domain d1i2sa_: 1i2s A: [71104] |
| Domain d1i2sb_: 1i2s B: [71105] complexed with cit, na |
| Domain d1i2wa_: 1i2w A: [71106] |
| Domain d1i2wb_: 1i2w B: [71107] complexed with cfx, out |
| Domain d1mbla_: 1mbl A: [42723] |
| Domain d1mblb_: 1mbl B: [42724] complexed with so4; mutant |
| Domain d2blma_: 2blm A: [42725] |
| Domain d2blmb_: 2blm B: [42726] CA-atoms only |
| Domain d4blma_: 4blm A: [42721] |
| Domain d4blmb_: 4blm B: [42722] |
| Enterobacter cloacae, NMC-A carbapenemase [TaxId:550] [56613] (2 PDB entries) |
| Domain d1buea_: 1bue A: [42727] |
| Domain d1bul__: 1bul - [42728] complexed with ap3, mes |
| Escherichia coli, TEM-1 [TaxId:562] [56607] (21 PDB entries) |
| Domain d1axb__: 1axb - [42695] complexed with fos; mutant |
| Domain d1bt5a_: 1bt5 A: [42693] complexed with im2, so4; mutant |
| Domain d1btl__: 1btl - [42691] complexed with so4 |
| Domain d1ck3a_: 1ck3 A: [42698] mutant |
| Domain d1erma_: 1erm A: [42690] complexed with bji |
| Domain d1eroa_: 1ero A: [42700] complexed with bjp |
| Domain d1erqa_: 1erq A: [42697] complexed with bjh |
| Domain d1esua_: 1esu A: [42696] complexed with so4; mutant |
| Domain d1fqga_: 1fqg A: [42699] acyl-enzyme intermediate ultra high resolution structure complexed with pnm; mutant |
| Domain d1jtda_: 1jtd A: [67264] Other proteins in same PDB: d1jtdb_ complexed with ca |
| Domain d1jtga_: 1jtg A: [67266] Other proteins in same PDB: d1jtgb_, d1jtgd_ |
| Domain d1jtgc_: 1jtg C: [67268] Other proteins in same PDB: d1jtgb_, d1jtgd_ complexed with ca; mutant |
| Domain d1jvja_: 1jvj A: [71896] complexed with im2, k; mutant |
| Domain d1jwpa_: 1jwp A: [71917] complexed with po4; mutant |
| Domain d1jwva_: 1jwv A: [71918] complexed with cb4, k; mutant |
| Domain d1jwza_: 1jwz A: [71922] TEM-64 variant complexed with 105; mutant |
| Domain d1lhya_: 1lhy A: [77967] TEM-30 variant complexed with po4; mutant |
| Domain d1li0a_: 1li0 A: [77968] TEM-32 variant complexed with bct, k; mutant |
| Domain d1li9a_: 1li9 A: [77969] TEM-34 variant complexed with k, po4; mutant |
| Domain d1m40a_: 1m40 A: [74437] complexed with cb4, k, po4; mutant |
| Domain d1tem__: 1tem - [42692] complexed with alp |
| Domain d1xpb__: 1xpb - [42694] complexed with so4 |
| Escherichia coli, TOHO-1 [TaxId:562] [56608] (4 PDB entries) |
| Domain d1bza__: 1bza - [42701] complexed with so4; mutant |
| Domain d1iyoa_: 1iyo A: [76970] complexed with cef, so4; mutant |
| Domain d1iypa_: 1iyp A: [76971] complexed with cep, so4; mutant |
| Domain d1iyqa_: 1iyq A: [76972] complexed with pnm, so4; mutant |
| Klebsiella pneumoniae, SHV-1 [TaxId:573] [56609] (2 PDB entries) |
| Domain d1g56a_: 1g56 A: [42702] inhibited by tazobactam complexed with akr, ma4, taz |
| Domain d1shva_: 1shv A: [42703] complexed with ma4 |
| Klebsiella pneumoniae, TEM52 [TaxId:573] [64473] (1 PDB entry) |
| Domain d1htza_: 1htz A: [61262] |
| Domain d1htzb_: 1htz B: [61263] |
| Domain d1htzc_: 1htz C: [61264] |
| Domain d1htzd_: 1htz D: [61265] |
| Domain d1htze_: 1htz E: [61266] |
| Domain d1htzf_: 1htz F: [61267] mutant |
| Mycobacterium fortuitum [TaxId:1766] [56615] (1 PDB entry) |
| Domain d1mfoa_: 1mfo A: [42730] |
| Proteus vulgaris [TaxId:585] [75596] (1 PDB entry) |
| Domain d1hzoa_: 1hzo A: [71092] |
| Domain d1hzob_: 1hzo B: [71093] complexed with mes |
| Pseudomonas aeruginosa, PER-1 [TaxId:287] [56616] (1 PDB entry) |
| Domain d1e25a_: 1e25 A: [42731] complexed with so4; mutant |
| Pseudomonas aeruginosa, PSE-4 carbenicillinase [TaxId:287] [56610] (2 PDB entries) |
| Domain d1g68a_: 1g68 A: [42705] complexed with so4 |
| Domain d1g6aa_: 1g6a A: [42704] complexed with so4; mutant |
| Serratia marcescens, Sme-1 [TaxId:615] [56617] (1 PDB entry) imipenem-hydrolyzing |
| Domain d1dy6a_: 1dy6 A: [42732] |
| Domain d1dy6b_: 1dy6 B: [42733] |
| Staphylococcus aureus [TaxId:1280] [56611] (16 PDB entries) |
| Domain d1alq__: 1alq - [42707] circularly permuted complexed with co3, so4; mutant |
| Domain d1blc__: 1blc - [42714] complexed with cem, so4, tem |
| Domain d1blh__: 1blh - [42713] complexed with fos |
| Domain d1blp__: 1blp - [42716] mutant |
| Domain d1dja__: 1dja - [42706] mutant |
| Domain d1djb__: 1djb - [42711] mutant |
| Domain d1djc__: 1djc - [42710] complexed with so4; mutant |
| Domain d1ghia_: 1ghi A: [60518] complexed with co3; mutant |
| Domain d1ghma_: 1ghm A: [60519] complexed with ced, co3, so4; mutant |
| Domain d1ghpa_: 1ghp A: [60520] complexed with pnm, so4; mutant |
| Domain d1kge__: 1kge - [42708] mutant |
| Domain d1kgf__: 1kgf - [42712] mutant |
| Domain d1kgga_: 1kgg A: [42715] complexed with so4; mutant |
| Domain d1omea_: 1ome A: [42717] |
| Domain d1omeb_: 1ome B: [42718] omega loop deletion mutant (residues 163-178 deleted) |
| Domain d1pioa_: 1pio A: [42719] |
| Domain d1piob_: 1pio B: [42720] mutant |
| Domain d3blm__: 3blm - [42709] |
| Streptomyces albus G [TaxId:1962] [56614] (1 PDB entry) |
| Domain d1bsg__: 1bsg - [42729] complexed with act |
Timeline for Protein beta-Lactamase, class A from e.3.1.1: beta-Lactamase/D-ala carboxypeptidase: