Lineage for Family d.3.1.1: Papain-like

  1. Root: SCOPe 2.08
  2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. Fold d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. Superfamily d.3.1: Cysteine proteinases [54001] (24 families) (S)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  5. Family d.3.1.1: Papain-like [54002] (26 proteins)

Proteins:

  1. (Pro)cathepsin B [54022] (3 species)
    1. Species Cow (Bos taurus) [TaxId:9913] [54025] (3 PDB entries)
    2. Species Human (Homo sapiens) [TaxId:9606] [54023] (6 PDB entries)
    3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [54024] (4 PDB entries)
  2. (Pro)cathepsin K [54028] (3 species)
    1. Species Human (Homo sapiens) [TaxId:9606] [54029] (56 PDB entries)
      Uniprot P43235 116-329 ! Uniprot P43235 115-329
    2. Species Mouse (Mus musculus) [TaxId:10090] [328741] (2 PDB entries)
    3. Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [142845] (1 PDB entry)
      Uniprot P43236 115-329
  3. (Pro)cathepsin L [54026] (1 species)
  4. (Pro)cathepsin S [82566] (1 species)
  5. (Pro)cathepsin V [64202] (1 species)
  6. (Pro)cathepsin X [54031] (1 species)
  7. Actinidin [54003] (1 species)
  8. Bleomycin hydrolase [54017] (2 species)
    DNA-binding protease that has more insertions in the papain-like fold
    1. Species Baker's yeast (Saccharomyces cerevisiae), Gal6 [TaxId:4932] [54018] (9 PDB entries)
    2. Species Human (Homo sapiens) [TaxId:9606] [54019] (2 PDB entries)
  9. Caricain (protease omega) [54007] (1 species)
  10. Cathepsin C (dipeptidyl peptidase I), catalytic domain [75330] (2 species)
    1. Species Human (Homo sapiens) [TaxId:9606] [75331] (1 PDB entry)
    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [82565] (1 PDB entry)
  11. Cathepsin F [89805] (1 species)
  12. Cathepsin H [81637] (1 species)
    also contains a disulfide-bound minicathepsin H chain
  13. Chymopapain [54009] (1 species)
  14. Cruzain [54020] (1 species)
  15. Ervatamin B [89803] (1 species)
  16. Ervatamin C [102717] (1 species)
  17. Falcipain 2 [142846] (1 species)
  18. Glycyl endopeptidase [54011] (1 species)
  19. Major mite fecal allergen der p 1 [142848] (1 species)
  20. Papain [54005] (1 species)
  21. Proline-specific cysteine protease [54013] (1 species)
  22. Staphopain SspB [102721] (1 species)
  23. Staphopain StpA [54033] (1 species)
  24. Streptococcal pyrogenic exotoxin B [54035] (1 species)
  25. Vignain (bean endopeptidase) [102719] (1 species)
  26. automated matches [190264] (12 species)
    not a true protein
    1. Species Actinidia arguta [TaxId:64478] [189532] (4 PDB entries)
    2. Species Carica candamarcensis [TaxId:35926] [189214] (1 PDB entry)
    3. Species Cow (Bos taurus) [TaxId:9913] [187053] (8 PDB entries)
    4. Species Ervatamia coronaria [311236] (1 PDB entry)
    5. Species Ficus carica [TaxId:3494] [315519] (1 PDB entry)
    6. Species Human (Homo sapiens) [TaxId:9606] [187102] (9 PDB entries)
    7. Species Jacaratia mexicana [TaxId:309130] [187452] (1 PDB entry)
    8. Species Trypanosome (Leishmania mexicana) [TaxId:5665] [386469] (1 PDB entry)
    9. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [188686] (2 PDB entries)
    10. Species Mouse (Mus musculus) [TaxId:10090] [229208] (7 PDB entries)
    11. Species Tabernaemontana divaricata [TaxId:52861] [187993] (3 PDB entries)
    12. Species Trypanosoma brucei [TaxId:31286] [188393] (5 PDB entries)

More info for Family d.3.1.1: Papain-like

Timeline for Family d.3.1.1: Papain-like: