SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2154577Fold d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. 2154578Superfamily d.3.1: Cysteine proteinases [54001] (24 families) (S)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  5. 2154579Family d.3.1.1: Papain-like [54002] (26 protein domains)
  6. 2154605Protein (Pro)cathepsin K [54028] (2 species)
  7. 2154606Species Human (Homo sapiens) [TaxId:9606] [54029] (49 PDB entries)
    Uniprot P43235 116-329 ! Uniprot P43235 115-329

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1atk:
  2. Domain(s) for 1au0:
  3. Domain(s) for 1au2:
  4. Domain(s) for 1au3:
  5. Domain(s) for 1au4:
  6. Domain(s) for 1ayu:
  7. Domain(s) for 1ayv:
  8. Domain(s) for 1ayw:
  9. Domain(s) for 1bgo:
  10. Domain(s) for 1by8:
  11. Domain(s) for 1mem:
  12. Domain(s) for 1nl6:
    1. 2154659Domain d1nl6a_: 1nl6 A: [80619]
      complexed with 750
    2. 2154660Domain d1nl6b_: 1nl6 B: [80620]
      complexed with 750
  13. Domain(s) for 1nlj:
    1. 2154651Domain d1nlja_: 1nlj A: [80626]
      complexed with 2ca
    2. 2154652Domain d1nljb_: 1nlj B: [80627]
      complexed with 2ca
  14. Domain(s) for 1q6k:
  15. Domain(s) for 1snk:
  16. Domain(s) for 1tu6:
    1. 2154612Domain d1tu6a_: 1tu6 A: [107318]
      complexed with fsp, so4
    2. 2154613Domain d1tu6b_: 1tu6 B: [107319]
      complexed with fsp, so4
  17. Domain(s) for 1u9v:
  18. Domain(s) for 1u9w:
  19. Domain(s) for 1u9x:
  20. Domain(s) for 1vsn:
  21. Domain(s) for 1yk7:
  22. Domain(s) for 1yk8:
  23. Domain(s) for 1yt7:
  24. Domain(s) for 2ato:
  25. Domain(s) for 2aux:
  26. Domain(s) for 2auz:
  27. Domain(s) for 2bdl:
  28. Domain(s) for 2fdz:
  29. Domain(s) for 2ftd:
    1. 2154649Domain d2ftda_: 2ftd A: [134058]
      automated match to d2r6na1
      complexed with ili
    2. 2154650Domain d2ftdb_: 2ftd B: [134059]
      automated match to d2r6na1
      complexed with ili
  30. Domain(s) for 2r6n:
  31. Domain(s) for 3c9e:
  32. Domain(s) for 3kw9:
  33. Domain(s) for 3kwb:
    1. 2154626Domain d3kwbx_: 3kwb X: [199680]
      automated match to d1tu6a_
      complexed with orh
    2. 2154627Domain d3kwby_: 3kwb Y: [191890]
      automated match to d2r6na1
      complexed with orh
  34. Domain(s) for 3kwz:
  35. Domain(s) for 3kx1:
  36. Domain(s) for 3o0u:
  37. Domain(s) for 3o1g:
  38. Domain(s) for 3ovz:
  39. Domain(s) for 4dmx:
  40. Domain(s) for 4dmy:
    1. 2154609Domain d4dmya_: 4dmy A: [192344]
      automated match to d2r6na1
      complexed with 0lc, gol, so4
    2. 2154610Domain d4dmyb_: 4dmy B: [192345]
      automated match to d2r6na1
      complexed with 0lc, gol, so4
  41. Domain(s) for 4n79:
  42. Domain(s) for 4n8w:
  43. Domain(s) for 4x6h:
  44. Domain(s) for 4x6i:
  45. Domain(s) for 4x6j:
  46. Domain(s) for 4yv8:
  47. Domain(s) for 4yva:
  48. Domain(s) for 5jh3:
  49. Domain(s) for 7pck:
    1. 2154654Domain d7pcka_: 7pck A: [37079]
      contains propeptide
    2. 2154655Domain d7pckb_: 7pck B: [37080]
      contains propeptide
    3. 2154656Domain d7pckc_: 7pck C: [37081]
      contains propeptide
    4. 2154657Domain d7pckd_: 7pck D: [37082]
      contains propeptide

More info for Species Human (Homo sapiens) [TaxId:9606] from d.3.1.1 (Pro)cathepsin K

Timeline for Species Human (Homo sapiens) [TaxId:9606] from d.3.1.1 (Pro)cathepsin K: