Lineage for Family b.47.1.2: Eukaryotic proteases

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2055629Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2055630Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2055877Family b.47.1.2: Eukaryotic proteases [50514] (49 protein domains)

Protein Domains:

  1. 2055878(alpha,gamma)-chymotrypsin(ogen) [50522] (3 species)
    1. 2055879Species Cow (Bos taurus) [TaxId:9913] [50523] (60 PDB entries)
      Uniprot P00766
    2. 2055967Species Norway rat (Rattus norvegicus) [TaxId:10116] [89340] (1 PDB entry)
    3. 2055969Species Red fire ant (Solenopsis invicta) [TaxId:13686] [50524] (1 PDB entry)
  2. 20559727S NGF protease subunits [50559] (1 species)
    two pairs of homologous but non-identical chains
  3. 2055978Activated protein c (autoprothrombin IIa) [50579] (1 species)
  4. 2055982Alpha tryptase I [89341] (1 species)
  5. 2055988Beta-acrosin [50593] (2 species)
    1. 2055989Species Pig (Sus scrofa) [TaxId:9823] [50595] (1 PDB entry)
    2. 2055991Species Sheep (Ovis aries) [TaxId:9940] [50594] (1 PDB entry)
  6. 2055993beta-Tryptase [50546] (1 species)
    ring-like tetramer with active sites facing a central pore
  7. 2056061Cathepsin G [50548] (1 species)
  8. 2056067Chymase (mast cell protease I) [89343] (1 species)
  9. 2056080Chymase II (mast cell proteinase II) [50552] (1 species)
  10. 2056084Coagulation factor IXa, protease domain [50583] (2 species)
    1. 2056085Species Human (Homo sapiens) [TaxId:9606] [50585] (16 PDB entries)
    2. 2056096Species Pig (Sus scrofa) [TaxId:9823] [50584] (2 PDB entries)
  11. 2056099Coagulation factor VIIa [50550] (1 species)
  12. 2056152Coagulation factor Xa, protease domain [50574] (2 species)
    1. 2056153Species Cow (Bos taurus) [TaxId:9913] [50576] (1 PDB entry)
    2. 2056155Species Human (Homo sapiens) [TaxId:9606] [50575] (57 PDB entries)
      Uniprot P00742 235-467
  13. 2056217Coagulation factor Xa-trypsin chimera [50577] (1 species)
  14. 2056220Coagulation factor XI [117237] (1 species)
  15. Complement C1R protease, catalytic domain [74976] (1 species)
  16. 2056272Complement C1S protease, catalytic domain [63789] (1 species)
  17. 2056275Crab collagenase [50527] (1 species)
  18. 2056279Duodenase [63791] (1 species)
    new serine protease
  19. 2056282Elastase [50536] (4 species)
    1. 2056283Species Atlantic salmon (Salmo salar) [TaxId:8030] [50539] (1 PDB entry)
    2. 2056285Species Human (Homo sapiens) [TaxId:9606] [50537] (12 PDB entries)
    3. 2056299Species Pig (Sus scrofa) [TaxId:9823] [50538] (118 PDB entries)
    4. 2056419Species Worm (Eisenia fetida) [TaxId:6396] [74973] (2 PDB entries)
      fibrinolytic enzyme component A
  20. 2056426Enteropeptidase (enterokinase light chain) [50540] (1 species)
  21. 2056429Factor B [50561] (1 species)
  22. 2056436Factor D [50563] (1 species)
  23. 2056459Granzyme A [89345] (1 species)
  24. 2056468Granzyme B [50590] (2 species)
    1. 2056469Species Human (Homo sapiens) [TaxId:9606] [50592] (2 PDB entries)
    2. 2056473Species Norway rat (Rattus norvegicus) [TaxId:10116] [50591] (1 PDB entry)
  25. 2056476Granzyme K [82124] (1 species)
  26. 2056480Heparin binding protein, HBP [50544] (1 species)
    multifunctional protein (synonym: CAP37, azurocidin)
  27. 2056486Hepatocyte growth factor activator, HGFA [267665] (1 species)
  28. 2056491Hepatocyte growth factor, HGF [110239] (1 species)
  29. 2056495Hepsin, catalytic domain [101813] (1 species)
  30. 2056501HL collagenase [50529] (1 species)
  31. 2056507Kallikrein 6 [74974] (1 species)
  32. 2056512Kallikrein A [50555] (1 species)
  33. 2056519Kallikrein-13 [50572] (1 species)
  34. 2056523Mannan-binding lectin serine protease 2 (MASP-2), catalytic domain [110241] (1 species)
  35. 2056528Matriptase MTSP1 [69284] (1 species)
  36. 2056551Myeloblastin, PR3 [50581] (1 species)
  37. 2056557Neuropsin [50525] (1 species)
  38. 2056561Plasmin(ogen), catalytic domain [50588] (1 species)
  39. 2056580Procarboxypeptidase A-S6 subunit III (zymogen E) [50534] (1 species)
  40. 2056585Prostate specific antigen (PSA kallikrein) [82122] (1 species)
  41. 2056588Single chain tissue plasminogen activator [50567] (2 species)
    1. 2056589Species Human (Homo sapiens) [TaxId:9606] [50568] (1 PDB entry)
    2. 2056592Species Vampire bat (Desmodus rotundus) [TaxId:9430] [50569] (1 PDB entry)
  42. 2056594Thrombin [50531] (2 species)
    1. Species Cow (Bos taurus) [TaxId:9913] [50533] (19 PDB entries)
      Uniprot P00734 333-622
    2. 2056630Species Human (Homo sapiens) [TaxId:9606] [50532] (170 PDB entries)
      Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620
  43. 2056826Tonin [50557] (1 species)
  44. 2056829Trypsin(ogen) [50515] (9 species)
    1. 2056830Species Atlantic salmon (Salmo salar) [TaxId:8030] [50520] (11 PDB entries)
    2. 2056845Species Chum salmon (Oncorhynchus keta) [TaxId:8018] [82121] (1 PDB entry)
    3. 2056847Species Cow (Bos taurus) [TaxId:9913] [50516] (418 PDB entries)
      Uniprot P00760
    4. 2057264Species Fungus (Fusarium oxysporum) [TaxId:5507] [50521] (16 PDB entries)
    5. 2057281Species Human (Homo sapiens) [TaxId:9606] [50519] (4 PDB entries)
    6. 2057290Species Human (Homo sapiens), trypsin IV (brain isoform) [TaxId:9606] [69283] (12 PDB entries)
    7. 2057315Species Narrow-clawed crayfish (Pontastacus leptodactylus) [TaxId:6717] [141385] (2 PDB entries)
      Uniprot Q52V24 1-237
    8. 2057319Species Norway rat (Rattus norvegicus) [TaxId:10116] [50518] (37 PDB entries)
    9. 2057361Species Pig (Sus scrofa) [TaxId:9823] [50517] (34 PDB entries)
      Uniprot P00761 9-231 ! Uniprot P00761
  45. 2057401Two-chain tissue plasminogen activator (TC)-T-PA [50565] (1 species)
  46. 2057406Urokinase [50542] (1 species)
  47. 2057409Urokinase-type plasminogen activator (LMW U-PA), catalytic domain [50586] (1 species)
  48. 2057484Venom serine protease [50570] (2 species)
    1. 2057485Species Chinese green tree viper (Trimeresurus stejnegeri) [TaxId:39682] [50571] (1 PDB entry)
    2. 2057488Species Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [110238] (2 PDB entries)
      Uniprot Q9I8X1
  49. 2057491automated matches [190044] (14 species)
    not a true protein
    1. 2057492Species Agkistrodon contortrix [TaxId:8713] [187405] (2 PDB entries)
    2. 2057495Species Atlantic cod (Gadus morhua) [TaxId:8049] [188345] (1 PDB entry)
    3. 2057497Species Chum salmon (Oncorhynchus keta) [TaxId:8018] [189036] (3 PDB entries)
    4. 2057503Species Cow (Bos taurus) [TaxId:9913] [187001] (14 PDB entries)
    5. 2057519Species Daboia russellii [TaxId:343250] [196182] (3 PDB entries)
    6. 2057523Species Gloydius saxatilis [TaxId:92067] [195310] (1 PDB entry)
    7. 2057525Species Golden hamster (Mesocricetus auratus) [TaxId:10036] [188254] (1 PDB entry)
    8. 2057528Species Halys viper (Agkistrodon halys) [TaxId:8714] [195671] (1 PDB entry)
    9. 2057530Species Human (Homo sapiens) [TaxId:9606] [187233] (146 PDB entries)
    10. 2057691Species Jararacussu (Bothrops jararacussu) [TaxId:8726] [194232] (1 PDB entry)
    11. 2057693Species Macaca mulatta [TaxId:9541] [196009] (1 PDB entry)
    12. 2057696Species Mouse (Mus musculus) [TaxId:10090] [188816] (4 PDB entries)
    13. 2057701Species Oryzias latipes [TaxId:8090] [237103] (1 PDB entry)
    14. 2057704Species Pig (Sus scrofa) [TaxId:9823] [193403] (1 PDB entry)

More info for Family b.47.1.2: Eukaryotic proteases

Timeline for Family b.47.1.2: Eukaryotic proteases: