Lineage for Family b.47.1.2: Eukaryotic proteases

  1. Root: SCOPe 2.08
  2. 2739516Class b: All beta proteins [48724] (180 folds)
  3. 2794584Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2794585Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2794859Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

Proteins:

  1. 2794860(alpha,gamma)-chymotrypsin(ogen) [50522] (3 species)
    1. 2794861Species Cow (Bos taurus) [TaxId:9913] [50523] (66 PDB entries)
      Uniprot P00766
    2. 2794956Species Norway rat (Rattus norvegicus) [TaxId:10116] [89340] (1 PDB entry)
    3. 2794958Species Red fire ant (Solenopsis invicta) [TaxId:13686] [50524] (1 PDB entry)
  2. 27949617S NGF protease subunits [50559] (1 species)
    two pairs of homologous but non-identical chains
  3. 2794967Activated protein c (autoprothrombin IIa) [50579] (1 species)
  4. 2794972Alpha tryptase I [89341] (1 species)
  5. 2794978Beta-acrosin [50593] (2 species)
    1. 2794979Species Pig (Sus scrofa) [TaxId:9823] [50595] (1 PDB entry)
    2. 2794981Species Sheep (Ovis aries) [TaxId:9940] [50594] (1 PDB entry)
  6. 2794983beta-Tryptase [50546] (1 species)
    ring-like tetramer with active sites facing a central pore
  7. 2795058Cathepsin G [50548] (1 species)
  8. 2795068Chymase (mast cell protease I) [89343] (1 species)
  9. 2795083Chymase II (mast cell proteinase II) [50552] (1 species)
  10. 2795087Coagulation factor IXa, protease domain [50583] (2 species)
    1. 2795088Species Human (Homo sapiens) [TaxId:9606] [50585] (21 PDB entries)
    2. 2795111Species Pig (Sus scrofa) [TaxId:9823] [50584] (2 PDB entries)
  11. 2795114Coagulation factor VIIa [50550] (1 species)
  12. 2795207Coagulation factor Xa, protease domain [50574] (2 species)
    1. 2795208Species Cow (Bos taurus) [TaxId:9913] [50576] (1 PDB entry)
    2. 2795210Species Human (Homo sapiens) [TaxId:9606] [50575] (58 PDB entries)
      Uniprot P00742 235-467
  13. 2795275Coagulation factor Xa-trypsin chimera [50577] (1 species)
  14. 2795278Coagulation factor XI [117237] (1 species)
  15. Complement C1R protease, catalytic domain [74976] (1 species)
  16. 2795348Complement C1S protease, catalytic domain [63789] (1 species)
  17. 2795351Crab collagenase [50527] (1 species)
  18. 2795355Duodenase [63791] (1 species)
    new serine protease
  19. 2795358Elastase [50536] (4 species)
    1. 2795359Species Atlantic salmon (Salmo salar) [TaxId:8030] [50539] (1 PDB entry)
    2. 2795361Species Human (Homo sapiens) [TaxId:9606] [50537] (15 PDB entries)
    3. 2795385Species Pig (Sus scrofa) [TaxId:9823] [50538] (123 PDB entries)
    4. 2795512Species Worm (Eisenia fetida) [TaxId:6396] [74973] (2 PDB entries)
      fibrinolytic enzyme component A
  20. 2795519Enteropeptidase (enterokinase light chain) [50540] (1 species)
  21. 2795522Factor B [50561] (1 species)
  22. 2795529Factor D [50563] (1 species)
  23. 2795599Granzyme A [89345] (1 species)
  24. 2795608Granzyme B [50590] (2 species)
    1. 2795609Species Human (Homo sapiens) [TaxId:9606] [50592] (2 PDB entries)
    2. 2795613Species Norway rat (Rattus norvegicus) [TaxId:10116] [50591] (1 PDB entry)
  25. 2795616Granzyme K [82124] (1 species)
  26. 2795620Heparin binding protein, HBP [50544] (1 species)
    multifunctional protein (synonym: CAP37, azurocidin)
  27. 2795626Hepatocyte growth factor activator, HGFA [267665] (1 species)
  28. 2795631Hepatocyte growth factor, HGF [110239] (1 species)
  29. 2795636Hepsin, catalytic domain [101813] (1 species)
  30. 2795642HL collagenase [50529] (1 species)
  31. 2795648Kallikrein 6 [74974] (1 species)
  32. 2795675Kallikrein A [50555] (1 species)
  33. 2795682Kallikrein-13 [50572] (1 species)
  34. 2795686Mannan-binding lectin serine protease 2 (MASP-2), catalytic domain [110241] (1 species)
  35. 2795691Matriptase MTSP1 [69284] (1 species)
  36. 2795716Myeloblastin, PR3 [50581] (1 species)
  37. 2795722Neuropsin [50525] (1 species)
  38. 2795726Plasmin(ogen), catalytic domain [50588] (1 species)
  39. 2795747Procarboxypeptidase A-S6 subunit III (zymogen E) [50534] (1 species)
  40. 2795752Prostate specific antigen (PSA kallikrein) [82122] (1 species)
  41. 2795755Single chain tissue plasminogen activator [50567] (2 species)
    1. 2795756Species Human (Homo sapiens) [TaxId:9606] [50568] (1 PDB entry)
    2. 2795759Species Vampire bat (Desmodus rotundus) [TaxId:9430] [50569] (1 PDB entry)
  42. 2795761Thrombin [50531] (2 species)
    1. Species Cow (Bos taurus) [TaxId:9913] [50533] (19 PDB entries)
      Uniprot P00734 333-622
    2. 2795797Species Human (Homo sapiens) [TaxId:9606] [50532] (171 PDB entries)
      Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620
  43. 2795994Tonin [50557] (1 species)
  44. 2795997Trypsin(ogen) [50515] (9 species)
    1. 2795998Species Atlantic salmon (Salmo salar) [TaxId:8030] [50520] (11 PDB entries)
    2. 2796013Species Chum salmon (Oncorhynchus keta) [TaxId:8018] [82121] (1 PDB entry)
    3. 2796015Species Cow (Bos taurus) [TaxId:9913] [50516] (498 PDB entries)
      Uniprot P00760
    4. 2796552Species Fungus (Fusarium oxysporum) [TaxId:5507] [50521] (16 PDB entries)
    5. 2796569Species Human (Homo sapiens) [TaxId:9606] [50519] (4 PDB entries)
    6. 2796578Species Human (Homo sapiens), trypsin IV (brain isoform) [TaxId:9606] [69283] (15 PDB entries)
    7. 2796614Species Narrow-clawed crayfish (Pontastacus leptodactylus) [TaxId:6717] [141385] (2 PDB entries)
      Uniprot Q52V24 1-237
    8. 2796618Species Norway rat (Rattus norvegicus) [TaxId:10116] [50518] (37 PDB entries)
    9. 2796660Species Pig (Sus scrofa) [TaxId:9823] [50517] (34 PDB entries)
      Uniprot P00761 9-231 ! Uniprot P00761
  45. 2796700Two-chain tissue plasminogen activator (TC)-T-PA [50565] (1 species)
  46. 2796705Urokinase [50542] (1 species)
  47. 2796708Urokinase-type plasminogen activator (LMW U-PA), catalytic domain [50586] (1 species)
  48. 2796816Venom serine protease [50570] (2 species)
    1. 2796817Species Chinese green tree viper (Trimeresurus stejnegeri) [TaxId:39682] [50571] (1 PDB entry)
    2. 2796820Species Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [110238] (2 PDB entries)
      Uniprot Q9I8X1
  49. 2796823automated matches [190044] (14 species)
    not a true protein
    1. 2796824Species Agkistrodon contortrix [TaxId:8713] [187405] (2 PDB entries)
    2. 2796827Species Atlantic cod (Gadus morhua) [TaxId:8049] [188345] (1 PDB entry)
    3. 2796829Species Chum salmon (Oncorhynchus keta) [TaxId:8018] [189036] (3 PDB entries)
    4. 2796835Species Cow (Bos taurus) [TaxId:9913] [187001] (23 PDB entries)
    5. 2796862Species Daboia russellii [TaxId:343250] [196182] (3 PDB entries)
    6. 2796866Species Gloydius saxatilis [TaxId:92067] [195310] (1 PDB entry)
    7. 2796868Species Golden hamster (Mesocricetus auratus) [TaxId:10036] [188254] (1 PDB entry)
    8. 2796871Species Halys viper (Agkistrodon halys) [TaxId:8714] [195671] (1 PDB entry)
    9. 2796873Species Human (Homo sapiens) [TaxId:9606] [187233] (139 PDB entries)
    10. 2797044Species Jararacussu (Bothrops jararacussu) [TaxId:8726] [194232] (1 PDB entry)
    11. 2797046Species Macaca mulatta [TaxId:9541] [196009] (1 PDB entry)
    12. 2797049Species Mouse (Mus musculus) [TaxId:10090] [188816] (5 PDB entries)
    13. 2797062Species Oryzias latipes [TaxId:8090] [237103] (1 PDB entry)
    14. 2797065Species Pig (Sus scrofa) [TaxId:9823] [193403] (1 PDB entry)

More info for Family b.47.1.2: Eukaryotic proteases

Timeline for Family b.47.1.2: Eukaryotic proteases: