SCOPe 2.08: Domain d2hsda_: 2hsd A:

Lineage for d2hsda_ (2hsd A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein 3-alpha,20-beta-hydroxysteroid dehydrogenase [51776] (1 species)

7. Species Streptomyces hydrogenans [TaxId:1905] [51777] (2 PDB entries)

8. Domain d2hsda_: 2hsd A: [29866]
   complexed with nad

Details for d2hsda_

PDB Entry: 2hsd, 2.64 Å

PDB Description: the refined three-dimensional structure of 3alpha,20beta- hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases

PDB Compounds: (A:) 3-alpha, 20 beta-hydroxysteroid dehydrogenase

SCOPe Domain Sequences for d2hsda_:

Sequence; same for both SEQRES and ATOM records:

>d2hsda_ c.2.1.2 (A:) 3-alpha,20-beta-hydroxysteroid dehydrogenase {Streptomyces hydrogenans [TaxId: 1905]}
ndlsgktviitggarglgaeaarqavaagarvvladvldeegaatarelgdaaryqhldv
tieedwqrvvayareefgsvdglvnnagistgmfletesverfrkvveinltgvfigmkt
vipamkdagggsivnissaaglmglaltssygaskwgvrglsklaavelgtdrirvnsvh
pgmtytpmtaetgirqgegnypntpmgrvgepgeiagavvkllsdtssyvtgaelavdgg
wttgptvkyvmgq

Timeline for d2hsda_:

• d2hsda_ first appeared (with stable ids) in SCOP 1.55
  
• d2hsda_ appears in SCOPe 2.07