SCOPe 2.08: Protein: 3-alpha,20-beta-hydroxysteroid dehydrogenase

Lineage for Protein: 3-alpha,20-beta-hydroxysteroid dehydrogenase

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
has additional subdomain(s) that are not in the common domain

Protein 3-alpha,20-beta-hydroxysteroid dehydrogenase [51776] (1 species)

Species:

Streptomyces hydrogenans [TaxId:1905] [51777] (2 PDB entries)
1. Domains for 1hdc:
  1. Domain d1hdca_: 1hdc A: [29862]
    complexed with cbo
  2. Domain d1hdcb_: 1hdc B: [29863]
    complexed with cbo
  3. Domain d1hdcc_: 1hdc C: [29864]
    complexed with cbo
  4. Domain d1hdcd_: 1hdc D: [29865]
    complexed with cbo
2. Domains for 2hsd:
  1. Domain d2hsda_: 2hsd A: [29866]
    complexed with nad
  2. Domain d2hsdb_: 2hsd B: [29867]
    complexed with nad
  3. Domain d2hsdc_: 2hsd C: [29868]
    complexed with nad
  4. Domain d2hsdd_: 2hsd D: [29869]
    complexed with nad

More info for Protein 3-alpha,20-beta-hydroxysteroid dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein 3-alpha,20-beta-hydroxysteroid dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases:

Protein 3-alpha,20-beta-hydroxysteroid dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases first appeared (with stable ids) in SCOP 1.55
Protein 3-alpha,20-beta-hydroxysteroid dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOPe 2.07