PDB entry 3mks

View 3mks on RCSB PDB site
Description: Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2
Class: ligase/cell cycle
Keywords: ubiquitin ligase, protein binding, small molecule complex, LIGASE/CELL CYCLE, LIGASE-CELL CYCLE complex
Deposited on 2010-04-15, released 2010-07-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-07-17, with a file datestamp of 2019-07-12.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Suppressor of kinetochore protein 1
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: SKP1, CBF3D, YDR328C, D9798.14
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3mksa1, d3mksa2
  • Chain 'B':
    Compound: Cell division control protein 4
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: CDC4, YFL009W
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07834 (Start-463)
      • see remark 999 (199)
    Domains in SCOPe 2.08: d3mksb1, d3mksb2
  • Chain 'C':
    Compound: Suppressor of kinetochore protein 1
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: SKP1, CBF3D, YDR328C, D9798.14
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3mksc1, d3mksc2
  • Chain 'D':
    Compound: Cell division control protein 4
    Species: Saccharomyces cerevisiae [TaxId:4932]
    Gene: CDC4, YFL009W
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07834 (Start-463)
      • see remark 999 (199)
    Domains in SCOPe 2.08: d3mksd1, d3mksd2
  • Heterogens: SO4, C1C, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3mksA (A:)
gahmvtsnvvlvsgegerftvdkkiaerslllknylndmgddddedddeivmpvpnvrss
vlqkviewaehhrdsnfpdeddddsrksapvdswdreflkvdqemlyeiilaanylnikp
lldagckvvaemirgrspeeirrtfnivndftpeeeaairrenewaedr

    Sequence, based on observed residues (ATOM records): (download) 
    >3mksA (A:)
snvvlvsgegerftvdkkiaerslllknyeivmpvpnvrssvlqkviewaehhrdsnfpd
ksapvdswdreflkvdqemlyeiilaanylnikplldagckvvaemirgrspeeirrtfn
ivndftpeeeaair

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3mksB (B:)
gagtlikdnlkrdlitslpfeislkifnylqfediinslgvsqnwnkiirkstslwkkll
isenfvspkgfnslnlklsqkypklsqqdrlrlsflenifilknwynpkfvpqrttlrgh
mtsvitclqfednyvitgaddkmirvydsinkkfllqlsghdggvwalkyahggilvsgs
tdrtvrvwdikkgccthvfeghnstvrcldiveyknikyivtgsrdntlhvwklpkessv
pdhgeehdyplvfhtpeenpyfvgvlrghmasvrtvsghgnivvsgsydntlivwdvaqm
kclyilsghtdriystiydherkrcisasmdttiriwdlengelmytlqghtalvgllrl
sdkflvsaaadgsirgwdandysrkfsyhhtnlsaittfyvsdnilvsgsenqfniynlr
sgklvhanilkdadqiwsvnfkgktlvaavekdgqsfleildfs

    Sequence, based on observed residues (ATOM records): (download) 
    >3mksB (B:)
lkrdlitslpfeislkifnylqfediinslgvsqnwnkiirkstslwkkllisenfvspk
gfnslnlklsqkypklsqqdrlrlsflenifilknwynpkfvpqrttlrghmtsvitclq
fednyvitgaddkmirvydsinkkfllqlsghdggvwalkyahggilvsgstdrtvrvwd
ikkgccthvfeghnstvrcldiveyknikyivtgsrdntlhvwklpkdyplvfhtpeenp
yfvgvlrghmasvrtvsghgnivvsgsydntlivwdvaqmkclyilsghtdriystiydh
erkrcisasmdttiriwdlengelmytlqghtalvgllrlsdkflvsaaadgsirgwdan
dysrkfsyhhtnlsaittfyvsdnilvsgsenqfniynlrsgklvhanilkdadqiwsvn
fkgktlvaavekdgqsfleildfs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3mksC (C:)
gahmvtsnvvlvsgegerftvdkkiaerslllknylndmgddddedddeivmpvpnvrss
vlqkviewaehhrdsnfpdeddddsrksapvdswdreflkvdqemlyeiilaanylnikp
lldagckvvaemirgrspeeirrtfnivndftpeeeaairrenewaedr

    Sequence, based on observed residues (ATOM records): (download) 
    >3mksC (C:)
snvvlvsgegerftvdkkiaerslllknylnivmpvpnvrssvlqkviewaehhrdsnfp
pvdswdreflkvdqemlyeiilaanylnikplldagckvvaemirgrspeeirrtfnivn
dftpeeeaairr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3mksD (D:)
gagtlikdnlkrdlitslpfeislkifnylqfediinslgvsqnwnkiirkstslwkkll
isenfvspkgfnslnlklsqkypklsqqdrlrlsflenifilknwynpkfvpqrttlrgh
mtsvitclqfednyvitgaddkmirvydsinkkfllqlsghdggvwalkyahggilvsgs
tdrtvrvwdikkgccthvfeghnstvrcldiveyknikyivtgsrdntlhvwklpkessv
pdhgeehdyplvfhtpeenpyfvgvlrghmasvrtvsghgnivvsgsydntlivwdvaqm
kclyilsghtdriystiydherkrcisasmdttiriwdlengelmytlqghtalvgllrl
sdkflvsaaadgsirgwdandysrkfsyhhtnlsaittfyvsdnilvsgsenqfniynlr
sgklvhanilkdadqiwsvnfkgktlvaavekdgqsfleildfs

    Sequence, based on observed residues (ATOM records): (download) 
    >3mksD (D:)
nlkrdlitslpfeislkifnylqfediinslgvsqnwnkiirkstslwkkllisenfvsp
kgfnslnlklsqkypklsqqdrlrlsflenifilknwynpkfvpqrttlrghmtsvitcl
qfednyvitgaddkmirvydsinkkfllqlsghdggvwalkyahggilvsgstdrtvrvw
dikkgccthvfeghnstvrcldiveyknikyivtgsrdntlhvwklpkeyplvfhtpeen
pyfvgvlrghmasvrtvsghgnivvsgsydntlivwdvaqmkclyilsghtdriystiyd
herkrcisasmdttiriwdlengelmytlqghtalvgllrlsdkflvsaaadgsirgwda
ndysrkfsyhhtnlsaittfyvsdnilvsgsenqfniynlrsgklvhanilkdadqiwsv
nfkgktlvaavekdgqsfleildfs