SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family b.47.1.3: Viral proteases

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2055629Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2055630Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2057706Family b.47.1.3: Viral proteases [50596] (5 protein domains)
    beta sheet in the first domain is opened rather than forms a barrel

Protein Domains:

  1. 2057707NS3 protease [50600] (5 species)
    1. 2057708Species Dengue virus 3 [TaxId:408693] [189803] (2 PDB entries)
    2. 2057712Species Dengue virus type 2 [TaxId:11060] [50602] (1 PDB entry)
    3. 2057714Species Hepatitis c virus subtype 1a [TaxId:31646] [254867] (2 PDB entries)
    4. 2057717Species Human hepatitis C virus (HCV), different isolates [TaxId:11103] [50601] (14 PDB entries)
      Uniprot P27958 1027-1206,1678-1669
      Uniprot P26662 1029-1202,1677-1689
      Uniprot O36579 1054-1207
    5. 2057745Species West Nile virus [TaxId:11082] [141386] (2 PDB entries)
      Uniprot P06935 1520-1671
  2. 2057748NSP4 proteinase [82128] (1 species)
    minimal fold; contains C-terminal extension
  3. 2057754TEV protease (nucleat inclusion protein A, NIA) [82126] (1 species)
  4. 2057762Viral capsid protein [50597] (3 species)
    1. 2057763Species Semliki forest virus [TaxId:11033] [50599] (2 PDB entries)
    2. 2057769Species Sindbis virus [TaxId:11034] [50598] (11 PDB entries)
    3. 2057789Species Venezuelan equine encephalitis virus [TaxId:11036] [89347] (2 PDB entries)
  5. 2057796automated matches [190658] (6 species)
    not a true protein
    1. 2057797Species Aura virus [TaxId:44158] [194195] (5 PDB entries)
    2. 2057804Species Hepatitis C virus subtype 1a [TaxId:31646] [226463] (19 PDB entries)
    3. 2057836Species Hepatitis C virus [TaxId:11103] [189262] (11 PDB entries)
    4. 2057852Species West Nile virus [TaxId:11082] [187751] (2 PDB entries)
    5. 2281104Species Zika virus (strain mr 766) [TaxId:64320] [324405] (1 PDB entry)
    6. 2283828Species Zika virus [TaxId:64320] [327129] (2 PDB entries)

More info for Family b.47.1.3: Viral proteases

Timeline for Family b.47.1.3: Viral proteases: