Lineage for Family b.47.1.3: Viral proteases

  1. Root: SCOPe 2.07
  2. 2344607Class b: All beta proteins [48724] (178 folds)
  3. 2387558Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2387559Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2389767Family b.47.1.3: Viral proteases [50596] (5 protein domains)
    beta sheet in the first domain is opened rather than forms a barrel

Protein Domains:

  1. 2389768NS3 protease [50600] (5 species)
    1. 2389769Species Dengue virus 3 [TaxId:408693] [189803] (2 PDB entries)
    2. 2389773Species Dengue virus type 2 [TaxId:11060] [50602] (1 PDB entry)
    3. 2389775Species Hepatitis C virus subtype 1a [TaxId:31646] [254867] (2 PDB entries)
    4. 2389778Species Human hepatitis C virus (HCV), different isolates [TaxId:11103] [50601] (14 PDB entries)
      Uniprot P27958 1027-1206,1678-1669
      Uniprot P26662 1029-1202,1677-1689
      Uniprot O36579 1054-1207
    5. 2389806Species West Nile virus [TaxId:11082] [141386] (2 PDB entries)
      Uniprot P06935 1520-1671
  2. 2389809NSP4 proteinase [82128] (1 species)
    minimal fold; contains C-terminal extension
  3. 2389815TEV protease (nucleat inclusion protein A, NIA) [82126] (1 species)
  4. 2389823Viral capsid protein [50597] (3 species)
    1. 2389824Species Semliki forest virus [TaxId:11033] [50599] (2 PDB entries)
    2. 2389830Species Sindbis virus [TaxId:11034] [50598] (11 PDB entries)
    3. 2389850Species Venezuelan equine encephalitis virus [TaxId:11036] [89347] (2 PDB entries)
  5. 2389857automated matches [190658] (7 species)
    not a true protein
    1. 2389858Species Aura virus [TaxId:44158] [194195] (5 PDB entries)
    2. 2389866Species Hepatitis C virus subtype 1a [TaxId:31646] [226463] (20 PDB entries)
    3. 2389898Species Hepatitis C virus [TaxId:11103] [189262] (12 PDB entries)
    4. 2389919Species West Nile virus [TaxId:11082] [187751] (2 PDB entries)
    5. 2389923Species Zika virus (strain mr 766) [TaxId:64320] [324405] (2 PDB entries)
    6. 2389929Species Zika virus [TaxId:64320] [327129] (4 PDB entries)
    7. 3046410Species Chikungunya virus [TaxId:37124] [346472] (1 PDB entry)

More info for Family b.47.1.3: Viral proteases

Timeline for Family b.47.1.3: Viral proteases: