Lineage for Family b.47.1.3: Viral proteases

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2055629Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2055630Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2057706Family b.47.1.3: Viral proteases [50596] (5 protein domains)
    beta sheet in the first domain is opened rather than forms a barrel

Protein Domains:

  1. 2057707NS3 protease [50600] (5 species)
    1. 2057708Species Dengue virus 3 [TaxId:408693] [189803] (2 PDB entries)
    2. 2057712Species Dengue virus type 2 [TaxId:11060] [50602] (1 PDB entry)
    3. 2057714Species Hepatitis c virus subtype 1a [TaxId:31646] [254867] (2 PDB entries)
    4. 2057717Species Human hepatitis C virus (HCV), different isolates [TaxId:11103] [50601] (14 PDB entries)
      Uniprot P27958 1027-1206,1678-1669
      Uniprot P26662 1029-1202,1677-1689
      Uniprot O36579 1054-1207
    5. 2057745Species West Nile virus [TaxId:11082] [141386] (2 PDB entries)
      Uniprot P06935 1520-1671
  2. 2057748NSP4 proteinase [82128] (1 species)
    minimal fold; contains C-terminal extension
  3. 2057754TEV protease (nucleat inclusion protein A, NIA) [82126] (1 species)
  4. 2057762Viral capsid protein [50597] (3 species)
    1. 2057763Species Semliki forest virus [TaxId:11033] [50599] (2 PDB entries)
    2. 2057769Species Sindbis virus [TaxId:11034] [50598] (11 PDB entries)
    3. 2057789Species Venezuelan equine encephalitis virus [TaxId:11036] [89347] (2 PDB entries)
  5. 2057796automated matches [190658] (6 species)
    not a true protein
    1. 2057797Species Aura virus [TaxId:44158] [194195] (5 PDB entries)
    2. 2057804Species Hepatitis C virus subtype 1a [TaxId:31646] [226463] (21 PDB entries)
    3. 2057836Species Hepatitis C virus [TaxId:11103] [189262] (11 PDB entries)
    4. 2057852Species West Nile virus [TaxId:11082] [187751] (2 PDB entries)
    5. 2281104Species Zika virus (strain mr 766) [TaxId:64320] [324405] (2 PDB entries)
    6. 2283828Species Zika virus [TaxId:64320] [327129] (2 PDB entries)

More info for Family b.47.1.3: Viral proteases

Timeline for Family b.47.1.3: Viral proteases: