SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Protein: automated matches

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2055629Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2055630Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2057706Family b.47.1.3: Viral proteases [50596] (5 protein domains)
    beta sheet in the first domain is opened rather than forms a barrel
  6. 2057796Protein automated matches [190658] (6 species)
    not a true protein

Species:

  1. 2057797Aura virus [TaxId:44158] [194195] (5 PDB entries)
    1. Domain for 4agj:
    2. Domain for 4agk:
    3. Domains for 4aus:
      1. 2057801Domain d4ausa1: 4aus A:110-261 [307031]
        Other proteins in same PDB: d4ausa2
        automated match to d1kxfa_
        complexed with gol
      2. 2057802Domain d4ausb_: 4aus B: [307033]
        Other proteins in same PDB: d4ausa2
        automated match to d1kxfa_
        complexed with gol
    4. Domains for 4uon:
      1. 2057799Domain d4uona1: 4uon A:110-261 [257700]
        Other proteins in same PDB: d4uona2
        automated match to d1kxfa_
        complexed with gol
      2. 2057800Domain d4uonb_: 4uon B: [260594]
        Other proteins in same PDB: d4uona2
        automated match to d1kxfa_
        complexed with gol
    5. Domain for 5g4b:
  2. 2057804Hepatitis C virus subtype 1a [TaxId:31646] [226463] (19 PDB entries)
    1. Domain for 3su0:
    2. Domain for 3su1:
    3. Domain for 3su2:
    4. Domain for 3su3:
    5. Domains for 3su4:
      1. 2057820Domain d3su4a_: 3su4 A: [233634]
        automated match to d3sv8a_
        complexed with so4, su3, zn
      2. 2057821Domain d3su4b_: 3su4 B: [233635]
        automated match to d3sv8a_
        complexed with so4, su3, zn
    6. Domain for 3su5:
    7. Domain for 3su6:
    8. Domains for 3sud:
      1. 2057816Domain d3suda_: 3sud A: [265371]
        automated match to d3sv6a_
        complexed with so4, sue, zn
      2. 2057817Domain d3sudb_: 3sud B: [265372]
        automated match to d3sv6a_
        complexed with so4, sue, zn
      3. 2057818Domain d3sudc_: 3sud C: [265373]
        automated match to d3sv6a_
        complexed with so4, sue, zn
      4. 2057819Domain d3sudd_: 3sud D: [265374]
        automated match to d3sv6a_
        complexed with so4, sue, zn
    9. Domains for 3sue:
      1. 2057822Domain d3suea_: 3sue A: [233636]
        automated match to d3sv8a_
        complexed with sue, zn
      2. 2057823Domain d3sueb_: 3sue B: [239775]
        automated match to d3suea_
        complexed with sue, zn
      3. 2057824Domain d3suec_: 3sue C: [239776]
        automated match to d3suea_
        complexed with sue, zn
      4. 2057825Domain d3sued_: 3sue D: [239777]
        automated match to d3suea_
        complexed with sue, zn
    10. Domains for 3suf:
      1. 2057826Domain d3sufa_: 3suf A: [233637]
        automated match to d3sv8a_
        complexed with so4, sue, zn
      2. 2057827Domain d3sufb_: 3suf B: [239778]
        automated match to d3sufa_
        complexed with so4, sue, zn
      3. 2057828Domain d3sufc_: 3suf C: [239779]
        automated match to d3sufa_
        complexed with so4, sue, zn
      4. 2057829Domain d3sufd_: 3suf D: [239780]
        automated match to d3sufa_
        complexed with so4, sue, zn
    11. Domain for 3sug:
    12. Domain for 3sv6:
    13. Domain for 3sv7:
    14. Domain for 3sv8:
    15. Domain for 3sv9:
    16. Domain for 4nwk:
    17. Domains for 4nwl:
      1. 2057832Domain d4nwla1: 4nwl A:-10-182 [254029]
        Other proteins in same PDB: d4nwla2, d4nwlb2
        automated match to d4nwka_
        complexed with 2r9, zn
      2. 2057833Domain d4nwlb1: 4nwl B:-10-182 [254030]
        Other proteins in same PDB: d4nwla2, d4nwlb2
        automated match to d4nwka_
        complexed with 2r9, zn
    18. Domain for 4wh6:
    19. Domains for 4wh8:
      1. 2057834Domain d4wh8a1: 4wh8 A:1004-1179 [260466]
        Other proteins in same PDB: d4wh8a2, d4wh8b2
        automated match to d3m5la_
        complexed with 3m7, so4, zn
      2. 2057835Domain d4wh8b1: 4wh8 B:1004-1179 [261475]
        Other proteins in same PDB: d4wh8a2, d4wh8b2
        automated match to d3m5la_
        complexed with 3m7, so4, zn
  3. 2057836Hepatitis C virus [TaxId:11103] [189262] (11 PDB entries)
    1. Domain for 2k1q:
    2. Domains for 3kee:
      1. 2057839Domain d3keea_: 3kee A: [179300]
        automated match to d1a1qa_
        complexed with 30b, gol, zn
      2. 2057840Domain d3keeb_: 3kee B: [179301]
        automated match to d1a1qa_
        complexed with 30b, gol, zn
      3. 2057841Domain d3keec_: 3kee C: [179302]
        automated match to d1a1qa_
        complexed with 30b, gol, zn
      4. 2057842Domain d3keed_: 3kee D: [179303]
        automated match to d1a1qa_
        complexed with 30b, gol, zn
    3. Domains for 4k8b:
      1. 2057849Domain d4k8ba_: 4k8b A: [237959]
        automated match to d1a1qa_
        complexed with 1rr, so4, zn
      2. 2057850Domain d4k8bb_: 4k8b B: [237960]
        automated match to d1a1qa_
        complexed with 1rr, so4, zn
    4. Domain for 4wf8:
    5. Domain for 5epn:
    6. Domain for 5epy:
    7. Domain for 5eqq:
    8. Domain for 5eqr:
    9. Domain for 5eqs:
    10. Domain for 5esb:
    11. Domains for 5etx:
      1. 2057845Domain d5etxa1: 5etx A:1005-1180 [280361]
        Other proteins in same PDB: d5etxa2, d5etxb2, d5etxc2, d5etxd2
        automated match to d3sv9a_
        complexed with 5rs, cl, zn
      2. 2057846Domain d5etxb1: 5etx B:1004-1180 [280360]
        Other proteins in same PDB: d5etxa2, d5etxb2, d5etxc2, d5etxd2
        automated match to d3sv9a_
        complexed with 5rs, cl, zn
      3. 2057847Domain d5etxc1: 5etx C:1004-1179 [280362]
        Other proteins in same PDB: d5etxa2, d5etxb2, d5etxc2, d5etxd2
        automated match to d3sv9a_
        complexed with 5rs, cl, zn
      4. 2057848Domain d5etxd1: 5etx D:1006-1180 [280363]
        Other proteins in same PDB: d5etxa2, d5etxb2, d5etxc2, d5etxd2
        automated match to d3sv9a_
        complexed with 5rs, cl, zn
  4. 2057852West Nile virus [TaxId:11082] [187751] (2 PDB entries)
    1. Domain for 2ggv:
    2. Domains for 3e90:
      1. 2057854Domain d3e90b_: 3e90 B: [174762]
        Other proteins in same PDB: d3e90a_, d3e90c_
        automated match to d2ijob1
        protein/RNA complex; complexed with nkk
      2. 2057855Domain d3e90d_: 3e90 D: [174763]
        Other proteins in same PDB: d3e90a_, d3e90c_
        automated match to d2ijob1
        protein/RNA complex; complexed with nkk
  5. 2281104Zika virus (strain mr 766) [TaxId:64320] [324405] (2 PDB entries)
    1. Domains for 5gj4:
      1. 2281105Domain d5gj4b_: 5gj4 B: [324406]
        Other proteins in same PDB: d5gj4a1, d5gj4c1, d5gj4e1, d5gj4g1
        automated match to d3e90d_
        complexed with cl
      2. 2281110Domain d5gj4d_: 5gj4 D: [324411]
        Other proteins in same PDB: d5gj4a1, d5gj4c1, d5gj4e1, d5gj4g1
        automated match to d3e90d_
        complexed with cl
      3. 2281127Domain d5gj4f_: 5gj4 F: [324428]
        Other proteins in same PDB: d5gj4a1, d5gj4c1, d5gj4e1, d5gj4g1
        automated match to d3e90d_
        complexed with cl
      4. 2281173Domain d5gj4h_: 5gj4 H: [324474]
        Other proteins in same PDB: d5gj4a1, d5gj4c1, d5gj4e1, d5gj4g1
        automated match to d3e90d_
        complexed with cl
    2. Domain for 5h6v:
  6. 2283828Zika virus [TaxId:64320] [327129] (2 PDB entries)
    1. Domains for 5gpi:
      1. 2283829Domain d5gpif_: 5gpi F: [327130]
        Other proteins in same PDB: d5gpia_, d5gpic_, d5gpie_, d5gpig_
        automated match to d3e90b_
      2. 2283830Domain d5gpid_: 5gpi D: [327131]
        Other proteins in same PDB: d5gpia_, d5gpic_, d5gpie_, d5gpig_
        automated match to d3e90b_
      3. 2283849Domain d5gpih_: 5gpi H: [327150]
        Other proteins in same PDB: d5gpia_, d5gpic_, d5gpie_, d5gpig_
        automated match to d3e90b_
      4. 2283869Domain d5gpib_: 5gpi B: [327170]
        Other proteins in same PDB: d5gpia_, d5gpic_, d5gpie_, d5gpig_
        automated match to d3e90b_
    2. Domain for 5h4i:

More info for Protein automated matches from b.47.1.3: Viral proteases

Timeline for Protein automated matches from b.47.1.3: Viral proteases: