SCOPe 2.08: Domain d2hgsa1: 2hgs A:202-303

Lineage for d2hgsa1 (2hgs A:202-303)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.30: PreATP-grasp domain [52439] (1 superfamily)
   3 layers: a/b/a; parallel or mixed beta-sheet of 4 to 6 strands
   possible rudiment form of Rossmann-fold domain

4. Superfamily c.30.1: PreATP-grasp domain [52440] (10 families)
   precedes the ATP-grasp domain common to all superfamily members, can contain a substrate-binding function

5. Family c.30.1.4: Eukaryotic glutathione synthetase, substrate-binding domain [52460] (1 protein)
   circularly permuted version of prokaryotic enzyme
   automatically mapped to Pfam PF03199

6. Protein Eukaryotic glutathione synthetase, substrate-binding domain [52461] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [52462] (1 PDB entry)

8. Domain d2hgsa1: 2hgs A:202-303 [31722]
   Other proteins in same PDB: d2hgsa4
   complexed with adp, gsh, mg, so4

Details for d2hgsa1

PDB Entry: 2hgs, 2.1 Å

PDB Description: human glutathione synthetase

PDB Compounds: (A:) protein (glutathione synthetase)

SCOPe Domain Sequences for d2hgsa1:

Sequence; same for both SEQRES and ATOM records:

>d2hgsa1 c.30.1.4 (A:202-303) Eukaryotic glutathione synthetase, substrate-binding domain {Human (Homo sapiens) [TaxId: 9606]}
pnalvlliaqekernifdqraienellarnihvirrtfedisekgsldqdrrlfvdgqei
avvyfrdgymprqyslqnwearlllershaakcpdiatqlag

Timeline for d2hgsa1:

• d2hgsa1 first appeared (with stable ids) in SCOP 1.55
  
• d2hgsa1 appears in SCOPe 2.07