SCOPe 2.08: Domain d2hgsa4: 2hgs A:3-201,A:304-474

Lineage for d2hgsa4 (2hgs A:3-201,A:304-474)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.142: ATP-grasp [56058] (2 superfamilies)
   Consists of two subdomains with different alpha+beta folds
   shares functional and structural similarities with the PIPK and protein kinase superfamilies

4. Superfamily d.142.1: Glutathione synthetase ATP-binding domain-like [56059] (11 families)

5. Family d.142.1.6: Eukaryotic glutathione synthetase ATP-binding domain [56088] (1 protein)
   circularly permuted version of prokaryotic enzyme
   automatically mapped to Pfam PF03917

6. Protein Eukaryotic glutathione synthetase ATP-binding domain [56089] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56090] (1 PDB entry)

8. Domain d2hgsa4: 2hgs A:3-201,A:304-474 [75997]
   Other proteins in same PDB: d2hgsa1
   complexed with adp, gsh, mg, so4

Details for d2hgsa4

PDB Entry: 2hgs, 2.1 Å

PDB Description: human glutathione synthetase

PDB Compounds: (A:) protein (glutathione synthetase)

SCOPe Domain Sequences for d2hgsa4:

Sequence; same for both SEQRES and ATOM records:

>d2hgsa4 d.142.1.6 (A:3-201,A:304-474) Eukaryotic glutathione synthetase ATP-binding domain {Human (Homo sapiens) [TaxId: 9606]}
tnwgsllqdkqqleelarqavdralaegvllrtsqeptssevvsyapftlfpslvpsall
eqayavqmdfnllvdavsqnaafleqtlsstikqddftarlfdihkqvlkegiaqtvflg
lnrsdymfqrsadgspalkqieintisasfgglasrtpavhrhvlsvlsktkeagkilsn
npskglalgiakawelygsXtkkvqqelsrpgmlemllpgqpeavarlratfaglysldv
geegdqaiaealaapsrfvlkpqregggnnlygeemvqalkqlkdseerasyilmekiep
epfencllrpgsparvvqciselgifgvyvrqektlvmnkhvghllrtkaiehadggvaa
gvavldnpypv

Timeline for d2hgsa4:

• d2hgsa4 first appeared in SCOP 1.63
  
• d2hgsa4 appears in SCOPe 2.07