PDB entry 5ume

View 5ume on RCSB PDB site
Description: Crystal Structure of 5,10-Methylenetetrahydrofolate Reductase MetF from Haemophilus influenzae
Class: oxidoreductase
Keywords: alpha-beta structure, TIM barrel, Structural Genomics, Center for Structural Genomics of Infectious Diseases, CSGID, OXIDOREDUCTASE
Deposited on 2017-01-27, released 2017-02-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-09-13, with a file datestamp of 2017-09-08.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5,10-Methylenetetrahydrofolate reductase
    Species: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [TaxId:71421]
    Gene: metF, HI_1444
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5umea_
  • Chain 'B':
    Compound: 5,10-Methylenetetrahydrofolate reductase
    Species: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [TaxId:71421]
    Gene: metF, HI_1444
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5umeb_
  • Chain 'C':
    Compound: 5,10-Methylenetetrahydrofolate reductase
    Species: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [TaxId:71421]
    Gene: metF, HI_1444
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5umec_
  • Chain 'D':
    Compound: 5,10-Methylenetetrahydrofolate reductase
    Species: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [TaxId:71421]
    Gene: metF, HI_1444
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5umed_
  • Chain 'E':
    Compound: 5,10-Methylenetetrahydrofolate reductase
    Species: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [TaxId:71421]
    Gene: metF, HI_1444
    Database cross-references and differences (RAF-indexed):
    • Uniprot P45208 (3-294)
      • expression tag (1-2)
    Domains in SCOPe 2.08: d5umee1, d5umee2
  • Chain 'F':
    Compound: 5,10-Methylenetetrahydrofolate reductase
    Species: Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [TaxId:71421]
    Gene: metF, HI_1444
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5umef_
  • Heterogens: FAD, SO4, ACY, EDO, FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5umeA (A:)
snamsyakeidtlnqhiadfnkkinvsfeffppknekmetllwdsihrlkvlkpkfvsvt
ygansgerdrthgivkaikqetgleaaphltgidatpeelkqiardywdsgirrivalrg
depkgyakkpfyasdlvellrsvadfdisvaaypevhpeaksaqadlinlkrkidaganh
vitqfffdienylrfrdrcasigidteivpgilpvtnfkqlqkmasftnvkipawlvkay
dgldndpttrnlvaasvamdmvkilsregvndfhfytlnrseltyaichmlgvrp

    Sequence, based on observed residues (ATOM records): (download) 
    >5umeA (A:)
yakeidtlnqhiadfnkkinvsfeffppknekmetllwdsihrlkvlkpkfvsvtygans
gerdrthgivkaikqetgleaaphltgidatpeelkqiardywdsgirrivalrgdepkp
fyasdlvellrsvadfdisvaaypevhpeaksaqadlinlkrkidaganhvitqfffdie
nylrfrdrcasigidteivpgilpvtnfkqlqkmasftnvkipawlvkaydgldndpttr
nlvaasvamdmvkilsregvndfhfytlnrseltyaichmlgvrp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5umeB (B:)
snamsyakeidtlnqhiadfnkkinvsfeffppknekmetllwdsihrlkvlkpkfvsvt
ygansgerdrthgivkaikqetgleaaphltgidatpeelkqiardywdsgirrivalrg
depkgyakkpfyasdlvellrsvadfdisvaaypevhpeaksaqadlinlkrkidaganh
vitqfffdienylrfrdrcasigidteivpgilpvtnfkqlqkmasftnvkipawlvkay
dgldndpttrnlvaasvamdmvkilsregvndfhfytlnrseltyaichmlgvrp

    Sequence, based on observed residues (ATOM records): (download) 
    >5umeB (B:)
kinvsfeffppknekmetllwdsihrlkvlkpkfvsvtysgerdrthgivkaikqetgle
aaphltgidatpeelkqiardywdsgirrivalrgdpfyasdlvellrsvadfdisvaay
pevhpeaksaqadlinlkrkidaganhvitqfffdienylrfrdrcasigidteivpgil
pvtnfkqlqkmasftnvkipawlvkaydgldndpttrnlvaasvamdmvkilsregvndf
hfytlnrseltyaichmlgvrp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5umeC (C:)
snamsyakeidtlnqhiadfnkkinvsfeffppknekmetllwdsihrlkvlkpkfvsvt
ygansgerdrthgivkaikqetgleaaphltgidatpeelkqiardywdsgirrivalrg
depkgyakkpfyasdlvellrsvadfdisvaaypevhpeaksaqadlinlkrkidaganh
vitqfffdienylrfrdrcasigidteivpgilpvtnfkqlqkmasftnvkipawlvkay
dgldndpttrnlvaasvamdmvkilsregvndfhfytlnrseltyaichmlgvrp

    Sequence, based on observed residues (ATOM records): (download) 
    >5umeC (C:)
akeidtlnqhiadfnkkinvsfeffppknekmetllwdsihrlkvlkpkfvsvtygansg
erdrthgivkaikqetgleaaphltgidatpeelkqiardywdsgirrivalrgdepakk
pfyasdlvellrsvadfdisvaaypevhpeaksaqadlinlkrkidaganhvitqfffdi
enylrfrdrcasigidteivpgilpvtnfkqlqkmasftnvkipawlvkaydgldndptt
rnlvaasvamdmvkilsregvndfhfytlnrseltyaichmlgvrp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5umeD (D:)
snamsyakeidtlnqhiadfnkkinvsfeffppknekmetllwdsihrlkvlkpkfvsvt
ygansgerdrthgivkaikqetgleaaphltgidatpeelkqiardywdsgirrivalrg
depkgyakkpfyasdlvellrsvadfdisvaaypevhpeaksaqadlinlkrkidaganh
vitqfffdienylrfrdrcasigidteivpgilpvtnfkqlqkmasftnvkipawlvkay
dgldndpttrnlvaasvamdmvkilsregvndfhfytlnrseltyaichmlgvrp

    Sequence, based on observed residues (ATOM records): (download) 
    >5umeD (D:)
syakeidtlnqhiankkinvsfeffppknekmetllwdsihrlkvlkpkfvsvtygansg
erdrthgivkaikqetgleaaphltgidatpeelkqiardywdsgirrivalrgdepkgy
akkpfyasdlvellrsvadfdisvaaypevhpeaksaqadlinlkrkidaganhvitqff
fdienylrfrdrcasigidteivpgilpvtnfkqlqkmasftnvkipawlvkaydgldnd
pttrnlvaasvamdmvkilsregvndfhfytlnrseltyaichmlgvrp

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5umeE (E:)
snamsyakeidtlnqhiadfnkkinvsfeffppknekmetllwdsihrlkvlkpkfvsvt
ygansgerdrthgivkaikqetgleaaphltgidatpeelkqiardywdsgirrivalrg
depkgyakkpfyasdlvellrsvadfdisvaaypevhpeaksaqadlinlkrkidaganh
vitqfffdienylrfrdrcasigidteivpgilpvtnfkqlqkmasftnvkipawlvkay
dgldndpttrnlvaasvamdmvkilsregvndfhfytlnrseltyaichmlgvrp

    Sequence, based on observed residues (ATOM records): (download) 
    >5umeE (E:)
namsyakeidtlnqhiadkkinvsfeffppknekmetllwdsihrlkvlkpkfvsvtyga
nsgerdrthgivkaikqetgleaaphltgidatpeelkqiardywdsgirrivalrgdep
kgyakkpfyasdlvellrsvadfdisvaaypevhpeaksaqadlinlkrkidaganhvit
qfffdienylrfrdrcasigidteivpgilpvtnfkqlqkmasftnvkipawlvkaydgl
dndpttrnlvaasvamdmvkilsregvndfhfytlnrseltyaichmlgvrp

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5umeF (F:)
snamsyakeidtlnqhiadfnkkinvsfeffppknekmetllwdsihrlkvlkpkfvsvt
ygansgerdrthgivkaikqetgleaaphltgidatpeelkqiardywdsgirrivalrg
depkgyakkpfyasdlvellrsvadfdisvaaypevhpeaksaqadlinlkrkidaganh
vitqfffdienylrfrdrcasigidteivpgilpvtnfkqlqkmasftnvkipawlvkay
dgldndpttrnlvaasvamdmvkilsregvndfhfytlnrseltyaichmlgvrp

    Sequence, based on observed residues (ATOM records): (download) 
    >5umeF (F:)
idtlnqhiakinvsfeffppknekmetllwdsihrlkvlkpkfvsvtygansgerdrthg
ivkaikqetgleaaphltgidatpeelkqiardywdsgirrivalrgdepkgyakkpfya
sdlvellrsvadfdisvaaypevhpeaksaqadlinlkrkidaganhvitqfffdienyl
rfrdrcasigidteivpgilpvtnfkqlqkmasftnvkipawlvkaydgldndpttrnlv
aasvamdmvkilsregvndfhfytlnrseltyaichmlgvrp