SCOPe 2.08: Domain d1ozha2: 1ozh A:7-187

Lineage for d1ozha2 (1ozh A:7-187)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (8 proteins)
   the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology
   automatically mapped to Pfam PF02776

6. Protein Catabolic acetolactate synthase [102328] (1 species)

7. Species Klebsiella pneumoniae [TaxId:573] [102329] (3 PDB entries)

8. Domain d1ozha2: 1ozh A:7-187 [93834]
   Other proteins in same PDB: d1ozha1, d1ozha3, d1ozha4, d1ozhb1, d1ozhb3, d1ozhb4, d1ozhc1, d1ozhc3, d1ozhc4, d1ozhd1, d1ozhd3
   complexed with he3, mg, peg, pge, po4

Details for d1ozha2

PDB Entry: 1ozh, 2 Å

PDB Description: The crystal structure of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate.

PDB Compounds: (A:) Acetolactate synthase, catabolic

SCOPe Domain Sequences for d1ozha2:

Sequence, based on SEQRES records:

>d1ozha2 c.36.1.5 (A:7-187) Catabolic acetolactate synthase {Klebsiella pneumoniae [TaxId: 573]}
vrqwahgadlvvsqleaqgvrqvfgipgakidkvfdslldssiriipvrheanaafmaaa
vgritgkagvalvtsgpgcsnlitgmatansegdpvvalggavkradkakqvhqsmdtva
mfspvtkyaievtapdalaevvsnafraaeqgrpgsafvslpqdvvdgpvsgkvlpasga
p

Sequence, based on observed residues (ATOM records):

>d1ozha2 c.36.1.5 (A:7-187) Catabolic acetolactate synthase {Klebsiella pneumoniae [TaxId: 573]}
vrqwahgadlvvsqleaqgvrqvfgipgakidkvfdslldssiriipvrheanaafmaaa
vgritgkagvalvtsgpgcsnlitgmatansegdpvvalggavkradksmdtvamfspvt
kyaievtapdalaevvsnafraaeqgrpgsafvslpqdvvdgpvsgkvlpasgap

Timeline for d1ozha2:

• d1ozha2 first appeared in SCOP 1.67
  
• d1ozha2 appears in SCOPe 2.07