Lineage for Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module

  1. Root: SCOPe 2.08
  2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families) (S)
    there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
    two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
  5. Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module [88724] (8 proteins)
    the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpha/beta domain of Rossmann-like topology
    automatically mapped to Pfam PF02776

Proteins:

  1. Acetohydroxyacid synthase catalytic subunit [88733] (3 species)
    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88734] (8 PDB entries)
      Uniprot P07342 84-687
    2. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [314106] (3 PDB entries)
    3. Species Thale cress (Arabidopsis thaliana), chloroplast [TaxId:3702] [142204] (12 PDB entries)
      Uniprot P17597 86-280
  2. Benzoylformate decarboxylase [88731] (1 species)
  3. Carboxyethylarginine synthase [102330] (1 species)
  4. Catabolic acetolactate synthase [102328] (1 species)
  5. Indole-3-pyruvate decarboxylase [89648] (1 species)
  6. Oxalyl-CoA decarboxylase [142205] (1 species)
  7. Pyruvate decarboxylase [88725] (3 species)
    1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [88727] (2 PDB entries)
    2. Species Brewer's yeast (Saccharomyces uvarum) [TaxId:230603] [88726] (1 PDB entry)
    3. Species Zymomonas mobilis [TaxId:542] [88728] (1 PDB entry)
  8. Pyruvate oxidase [88729] (2 species)
    1. Species Aerococcus viridans [TaxId:1377] [142203] (2 PDB entries)
    2. Species Lactobacillus plantarum [TaxId:1590] [88730] (2 PDB entries)

More info for Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module

Timeline for Family c.36.1.5: Pyruvate oxidase and decarboxylase Pyr module: