SCOPe 2.01: Protein: Lactate dehydrogenase

Lineage for Protein: Lactate dehydrogenase

Root: SCOPe 2.01
Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
Fold d.162: LDH C-terminal domain-like [56326] (1 superfamily)
unusual fold, defines family
Superfamily d.162.1: LDH C-terminal domain-like [56327] (2 families)
Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (4 proteins)
N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
Protein Lactate dehydrogenase [56339] (15 species)

Species:

Archaeoglobus fulgidus [TaxId:2234] [111253] (2 PDB entries)
Uniprot O08349
1. Domain for 2x0i:
  - Domain d2x0ia2: 2x0i A:164-331 [169755]
    Other proteins in same PDB: d2x0ia1
    complexed with na, nad, so4
2. Domain for 2x0j:
  - Domain d2x0ja2: 2x0j A:164-331 [169757]
    Other proteins in same PDB: d2x0ja1
    complexed with ena, so4
Bacillus stearothermophilus [TaxId:1422] [56344] (3 PDB entries)
1. Domains for 1ldb:
  1. Domain d1ldba2: 1ldb A:163-331 [42141]
    Other proteins in same PDB: d1ldba1, d1ldbb1, d1ldbc1, d1ldbd1
    complexed with so4
  2. Domain d1ldbb2: 1ldb B:163-331 [118524]
    Other proteins in same PDB: d1ldba1, d1ldbb1, d1ldbc1, d1ldbd1
    duplicate of 1LDB 163-331
    complexed with so4
  3. Domain d1ldbc2: 1ldb C:163-331 [118526]
    Other proteins in same PDB: d1ldba1, d1ldbb1, d1ldbc1, d1ldbd1
    duplicate of 1LDB 163-331
    complexed with so4
  4. Domain d1ldbd2: 1ldb D:163-331 [118528]
    Other proteins in same PDB: d1ldba1, d1ldbb1, d1ldbc1, d1ldbd1
    duplicate of 1LDB 163-331
    complexed with so4
2. Domains for 1ldn:
  1. Domain d1ldna2: 1ldn A:163-330 [42133]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
    complexed with fbp, nad, oxm
  2. Domain d1ldnb2: 1ldn B:163-330 [42134]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
    complexed with fbp, nad, oxm
  3. Domain d1ldnc2: 1ldn C:163-330 [42135]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
    complexed with fbp, nad, oxm
  4. Domain d1ldnd2: 1ldn D:163-330 [42136]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
    complexed with fbp, nad, oxm
  5. Domain d1ldne2: 1ldn E:163-330 [42137]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
    complexed with fbp, nad, oxm
  6. Domain d1ldnf2: 1ldn F:163-330 [42138]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
    complexed with fbp, nad, oxm
  7. Domain d1ldng2: 1ldn G:163-330 [42139]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
    complexed with fbp, nad, oxm
  8. Domain d1ldnh2: 1ldn H:163-330 [42140]
    Other proteins in same PDB: d1ldna1, d1ldnb1, d1ldnc1, d1ldnd1, d1ldne1, d1ldnf1, d1ldng1, d1ldnh1
    complexed with fbp, nad, oxm
3. Domains for 2ldb:
  1. Domain d2ldba2: 2ldb A:163-331 [42142]
    Other proteins in same PDB: d2ldba1, d2ldbb1, d2ldbc1, d2ldbd1
    complexed with fbp, nad, so4
  2. Domain d2ldbb2: 2ldb B:163-331 [118637]
    Other proteins in same PDB: d2ldba1, d2ldbb1, d2ldbc1, d2ldbd1
    duplicate of 2LDB 163-331
    complexed with fbp, nad, so4
  3. Domain d2ldbc2: 2ldb C:163-331 [118639]
    Other proteins in same PDB: d2ldba1, d2ldbb1, d2ldbc1, d2ldbd1
    duplicate of 2LDB 163-331
    complexed with fbp, nad, so4
  4. Domain d2ldbd2: 2ldb D:163-331 [118641]
    Other proteins in same PDB: d2ldba1, d2ldbb1, d2ldbc1, d2ldbd1
    duplicate of 2LDB 163-331
    complexed with fbp, nad, so4
Bifidobacterium longum, strain am101-2 [TaxId:216816] [56346] (2 PDB entries)
1. Domains for 1lld:
  1. Domain d1llda2: 1lld A:150-319 [42144]
    Other proteins in same PDB: d1llda1, d1lldb1
    complexed with nad
  2. Domain d1lldb2: 1lld B:150-319 [42145]
    Other proteins in same PDB: d1llda1, d1lldb1
    complexed with nad
2. Domains for 1lth:
  1. Domain d1lthr2: 1lth R:150-319 [42146]
    Other proteins in same PDB: d1lthr1, d1ltht1
    complexed with fbp, nad, oxm
  2. Domain d1ltht2: 1lth T:150-319 [42147]
    Other proteins in same PDB: d1lthr1, d1ltht1
    complexed with fbp, nad, oxm
Clostridium thermocellum [TaxId:1515] [118160] (1 PDB entry)
Uniprot Q4CDK5
- Domain for 1y6j:
  - Domain d1y6ja2: 1y6j A:149-317 [116508]
    Other proteins in same PDB: d1y6ja1
    Structural genomics target
Dogfish (Squalus acanthias) [TaxId:7797] [56342] (3 PDB entries)
1. Domain for 1ldm:
  - Domain d1ldma2: 1ldm A:161-329 [42127]
    Other proteins in same PDB: d1ldma1
    complexed with nad, oxm
2. Domain for 6ldh:
  - Domain d6ldha2: 6ldh A:161-329 [42128]
    Other proteins in same PDB: d6ldha1
    complexed with so4
3. Domain for 8ldh:
  - Domain d8ldha2: 8ldh A:161-329 [42129]
    Other proteins in same PDB: d8ldha1
    complexed with cit
Human (Homo sapiens), heart isoform (H chain) [TaxId:9606] [64444] (2 PDB entries)
1. Domains for 1i0z:
  1. Domain d1i0za2: 1i0z A:161-332 [61496]
    Other proteins in same PDB: d1i0za1, d1i0zb1
    complexed with nai, oxm
  2. Domain d1i0zb2: 1i0z B:161-332 [61498]
    Other proteins in same PDB: d1i0za1, d1i0zb1
    complexed with nai, oxm
2. Domains for 1t2f:
  1. Domain d1t2fa2: 1t2f A:161-332 [99089]
    Other proteins in same PDB: d1t2fa1, d1t2fb1, d1t2fc1, d1t2fd1
    complexed with nad, oxq
  2. Domain d1t2fb2: 1t2f B:161-332 [99091]
    Other proteins in same PDB: d1t2fa1, d1t2fb1, d1t2fc1, d1t2fd1
    complexed with nad, oxq
  3. Domain d1t2fc2: 1t2f C:161-332 [99093]
    Other proteins in same PDB: d1t2fa1, d1t2fb1, d1t2fc1, d1t2fd1
    complexed with nad, oxq
  4. Domain d1t2fd2: 1t2f D:161-332 [99095]
    Other proteins in same PDB: d1t2fa1, d1t2fb1, d1t2fc1, d1t2fd1
    complexed with nad, oxq
Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [64445] (1 PDB entry)
- Domains for 1i10:
  1. Domain d1i10a2: 1i10 A:160-331 [61500]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
    complexed with act, nai, oxm
  2. Domain d1i10b2: 1i10 B:160-331 [61502]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
    complexed with act, nai, oxm
  3. Domain d1i10c2: 1i10 C:160-331 [61504]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
    complexed with act, nai, oxm
  4. Domain d1i10d2: 1i10 D:160-331 [61506]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
    complexed with act, nai, oxm
  5. Domain d1i10e2: 1i10 E:160-331 [61508]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
    complexed with act, nai, oxm
  6. Domain d1i10f2: 1i10 F:160-331 [61510]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
    complexed with act, nai, oxm
  7. Domain d1i10g2: 1i10 G:160-331 [61512]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
    complexed with act, nai, oxm
  8. Domain d1i10h2: 1i10 H:160-331 [61514]
    Other proteins in same PDB: d1i10a1, d1i10b1, d1i10c1, d1i10d1, d1i10e1, d1i10f1, d1i10g1, d1i10h1
    complexed with act, nai, oxm
Lactobacillus casei [TaxId:1582] [56345] (1 PDB entry)
- Domain for 1llc:
  - Domain d1llca2: 1llc A:165-334 [42143]
    Other proteins in same PDB: d1llca1
    complexed with afp, so4
Lactobacillus pentosus [TaxId:1589] [69843] (1 PDB entry)
- Domains for 1ez4:
  1. Domain d1ez4a2: 1ez4 A:163-334 [64918]
    Other proteins in same PDB: d1ez4a1, d1ez4b1, d1ez4c1, d1ez4d1
    complexed with nad
  2. Domain d1ez4b2: 1ez4 B:163-335 [64920]
    Other proteins in same PDB: d1ez4a1, d1ez4b1, d1ez4c1, d1ez4d1
    complexed with nad
  3. Domain d1ez4c2: 1ez4 C:163-334 [64922]
    Other proteins in same PDB: d1ez4a1, d1ez4b1, d1ez4c1, d1ez4d1
    complexed with nad
  4. Domain d1ez4d2: 1ez4 D:163-335 [64924]
    Other proteins in same PDB: d1ez4a1, d1ez4b1, d1ez4c1, d1ez4d1
    complexed with nad
Malaria parasite (Plasmodium falciparum) [TaxId:5833] [56343] (9 PDB entries)
1. Domain for 1ceq:
  - Domain d1ceqa2: 1ceq A:164-329 [42130]
    Other proteins in same PDB: d1ceqa1
2. Domain for 1cet:
  - Domain d1ceta2: 1cet A:164-329 [42131]
    Other proteins in same PDB: d1ceta1
    complexed with clq
3. Domain for 1ldg:
  - Domain d1ldga2: 1ldg A:164-329 [42132]
    Other proteins in same PDB: d1ldga1
    complexed with nad, oxm
4. Domain for 1t24:
  - Domain d1t24a2: 1t24 A:164-329 [99070]
    Other proteins in same PDB: d1t24a1
    complexed with gol, nad, oxq
5. Domain for 1t25:
  - Domain d1t25a2: 1t25 A:164-329 [99072]
    Other proteins in same PDB: d1t25a1
    complexed with gag, gol, nai
6. Domain for 1t26:
  - Domain d1t26a2: 1t26 A:164-330 [99074]
    Other proteins in same PDB: d1t26a1
    complexed with gbd, nai
7. Domain for 1t2c:
  - Domain d1t2ca2: 1t2c A:164-329 [99083]
    Other proteins in same PDB: d1t2ca1
    complexed with gol, nai
8. Domain for 1t2d:
  - Domain d1t2da2: 1t2d A:151-315 [99085]
    Other proteins in same PDB: d1t2da1
    complexed with gol, nad, oxl
9. Domain for 1t2e:
  - Domain d1t2ea2: 1t2e A:164-331 [99087]
    Other proteins in same PDB: d1t2ea1
    complexed with gol, nai, oxm; mutant
Mouse (Mus musculus) [TaxId:10090] [56341] (1 PDB entry)
- Domains for 2ldx:
  1. Domain d2ldxa2: 2ldx A:160-331 [42126]
    Other proteins in same PDB: d2ldxa1, d2ldxb1, d2ldxc1, d2ldxd1
  2. Domain d2ldxb2: 2ldx B:160-331 [118643]
    Other proteins in same PDB: d2ldxa1, d2ldxb1, d2ldxc1, d2ldxd1
    duplicate of 2LDX 160-331
  3. Domain d2ldxc2: 2ldx C:160-331 [118645]
    Other proteins in same PDB: d2ldxa1, d2ldxb1, d2ldxc1, d2ldxd1
    duplicate of 2LDX 160-331
  4. Domain d2ldxd2: 2ldx D:160-331 [118647]
    Other proteins in same PDB: d2ldxa1, d2ldxb1, d2ldxc1, d2ldxd1
    duplicate of 2LDX 160-331
Pig (Sus scrofa) [TaxId:9823] [56340] (3 PDB entries)
1. Domain for 5ldh:
  - Domain d5ldha2: 5ldh A:163-331 [42125]
    Other proteins in same PDB: d5ldha1
    complexed with cit, lnc
2. Domains for 9ldb:
  1. Domain d9ldba2: 9ldb A:163-331 [42123]
    Other proteins in same PDB: d9ldba1, d9ldbb1
    complexed with nad, oxm, so4
  2. Domain d9ldbb2: 9ldb B:163-331 [42124]
    Other proteins in same PDB: d9ldba1, d9ldbb1
    complexed with nad, oxm, so4
3. Domains for 9ldt:
  1. Domain d9ldta2: 9ldt A:163-331 [42121]
    Other proteins in same PDB: d9ldta1, d9ldtb1
    complexed with nad, oxm, so4
  2. Domain d9ldtb2: 9ldt B:163-331 [42122]
    Other proteins in same PDB: d9ldta1, d9ldtb1
    complexed with nad, oxm, so4
Plasmodium berghei [TaxId:5821] [103325] (7 PDB entries)
1. Domains for 1oc4:
  1. Domain d1oc4a2: 1oc4 A:164-329 [92771]
    Other proteins in same PDB: d1oc4a1, d1oc4b1
    complexed with gol, nad, oxm
  2. Domain d1oc4b2: 1oc4 B:164-329 [92773]
    Other proteins in same PDB: d1oc4a1, d1oc4b1
    complexed with gol, nad, oxm
2. Domain for 1u4o:
  - Domain d1u4oa2: 1u4o A:164-328 [119528]
    Other proteins in same PDB: d1u4oa1
    automatically matched to d1oc4a2
    complexed with mpd, ndd
3. Domain for 1u4s:
  - Domain d1u4sa2: 1u4s A:164-328 [119530]
    Other proteins in same PDB: d1u4sa1
    automatically matched to d1oc4a2
    complexed with bih
4. Domain for 1u5a:
  - Domain d1u5aa2: 1u5a A:164-328 [119533]
    Other proteins in same PDB: d1u5aa1
    automatically matched to d1oc4a2
    complexed with bik
5. Domain for 1u5c:
  - Domain d1u5ca2: 1u5c A:164-328 [119535]
    Other proteins in same PDB: d1u5ca1
    automatically matched to d1oc4a2
    complexed with bik, nad
6. Domain for 1xiv:
  - Domain d1xiva2: 1xiv A:164-328 [122019]
    Other proteins in same PDB: d1xiva1
    automatically matched to d1oc4a2
    complexed with gol, rb2
7. Domain for 2a94:
  - Domain d2a94a2: 2a94 A:164-328 [126424]
    Other proteins in same PDB: d2a94a1
    automatically matched to d1oc4a2
    complexed with ap0
Thermotoga maritima [TaxId:2336] [56347] (1 PDB entry)
- Domain for 1a5z:
  - Domain d1a5za2: 1a5z A:164-333 [42148]
    Other proteins in same PDB: d1a5za1
    complexed with cd, fbp, nad, oxm
Toxoplasma gondii [TaxId:5811] [103326] (4 PDB entries)
1. Domain for 1pze:
  - Domain d1pzea2: 1pze A:164-332 [95416]
    Other proteins in same PDB: d1pzea1
2. Domains for 1pzf:
  1. Domain d1pzfa2: 1pzf A:164-334 [95418]
    Other proteins in same PDB: d1pzfa1, d1pzfb1, d1pzfc1, d1pzfd1
    complexed with a3d, oxl
  2. Domain d1pzfb2: 1pzf B:164-334 [95420]
    Other proteins in same PDB: d1pzfa1, d1pzfb1, d1pzfc1, d1pzfd1
    complexed with a3d, oxl
  3. Domain d1pzfc2: 1pzf C:164-332 [95422]
    Other proteins in same PDB: d1pzfa1, d1pzfb1, d1pzfc1, d1pzfd1
    complexed with a3d, oxl
  4. Domain d1pzfd2: 1pzf D:164-332 [95424]
    Other proteins in same PDB: d1pzfa1, d1pzfb1, d1pzfc1, d1pzfd1
    complexed with a3d, oxl
3. Domains for 1pzg:
  1. Domain d1pzga2: 1pzg A:164-334 [95426]
    Other proteins in same PDB: d1pzga1, d1pzgb1, d1pzgc1, d1pzgd1
    complexed with a3d, so4
  2. Domain d1pzgb2: 1pzg B:164-334 [95428]
    Other proteins in same PDB: d1pzga1, d1pzgb1, d1pzgc1, d1pzgd1
    complexed with a3d, so4
  3. Domain d1pzgc2: 1pzg C:164-332 [95430]
    Other proteins in same PDB: d1pzga1, d1pzgb1, d1pzgc1, d1pzgd1
    complexed with a3d, so4
  4. Domain d1pzgd2: 1pzg D:164-332 [95432]
    Other proteins in same PDB: d1pzga1, d1pzgb1, d1pzgc1, d1pzgd1
    complexed with a3d, so4
4. Domains for 1pzh:
  1. Domain d1pzha2: 1pzh A:164-335 [95434]
    Other proteins in same PDB: d1pzha1, d1pzhb1, d1pzhc1, d1pzhd1
    complexed with nad, oxl
  2. Domain d1pzhb2: 1pzh B:164-335 [95436]
    Other proteins in same PDB: d1pzha1, d1pzhb1, d1pzhc1, d1pzhd1
    complexed with nad, oxl
  3. Domain d1pzhc2: 1pzh C:164-332 [95438]
    Other proteins in same PDB: d1pzha1, d1pzhb1, d1pzhc1, d1pzhd1
    complexed with nad, oxl
  4. Domain d1pzhd2: 1pzh D:164-332 [95440]
    Other proteins in same PDB: d1pzha1, d1pzhb1, d1pzhc1, d1pzhd1
    complexed with nad, oxl

More info for Protein Lactate dehydrogenase from d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain

Timeline for Protein Lactate dehydrogenase from d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain:

Protein Lactate dehydrogenase from d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain first appeared (with stable ids) in SCOP 1.55
Protein Lactate dehydrogenase from d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain appears in SCOP 1.75
Protein Lactate dehydrogenase from d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain appears in SCOPe 2.02
Protein Lactate dehydrogenase from d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain appears in the current release, SCOPe 2.08