SCOPe 2.08: Domain d1bhsa_: 1bhs A:

Lineage for d1bhsa_ (1bhs A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
   has additional subdomain(s) that are not in the common domain
   

6. Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51773] (22 PDB entries)
   Uniprot P14061

8. Domain d1bhsa_: 1bhs A: [29840]

Details for d1bhsa_

PDB Entry: 1bhs, 2.2 Å

PDB Description: human estrogenic 17beta-hydroxysteroid dehydrogenase

PDB Compounds: (A:) 17beta-hydroxysteroid dehydrogenase

SCOPe Domain Sequences for d1bhsa_:

Sequence; same for both SEQRES and ATOM records:

>d1bhsa_ c.2.1.2 (A:) Human estrogenic 17beta-hydroxysteroid dehydrogenase {Human (Homo sapiens) [TaxId: 9606]}
artvvlitgcssgiglhlavrlasdpsqsfkvyatlrdlktqgrlweaaralacppgsle
tlqldvrdsksvaaarervtegrvdvlvcnaglgllgplealgedavasvldvnvvgtvr
mlqaflpdmkrrgsgrvlvtgsvgglmglpfndvycaskfaleglceslavlllpfgvhl
sliecgpvhtafmekvlgspeevldrtdihtfhrfyqylahskqvfreaaqnpeevaevf
ltalrapkptlryftterflpllrmrlddpsgsnyvtamhrevf

Timeline for d1bhsa_:

• d1bhsa_ first appeared (with stable ids) in SCOP 1.55, called d1bhs__
  
• d1bhsa_ appears in SCOPe 2.07