SCOPe 2.08: Protein: Human estrogenic 17beta-hydroxysteroid dehydrogenase

Lineage for Protein: Human estrogenic 17beta-hydroxysteroid dehydrogenase

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
has additional subdomain(s) that are not in the common domain

Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)

Species:

Human (Homo sapiens) [TaxId:9606] [51773] (22 PDB entries)
Uniprot P14061
1. Domain for 1a27:
  - Domain d1a27a_: 1a27 A: [29839]
    complexed with est, nap; mutant
2. Domain for 1bhs:
  - Domain d1bhsa_: 1bhs A: [29840]
3. Domain for 1dht:
  - Domain d1dhta_: 1dht A: [29843]
    complexed with dht
4. Domains for 1equ:
  1. Domain d1equa_: 1equ A: [29846]
    complexed with eqi, nap
  2. Domain d1equb_: 1equ B: [29847]
    complexed with eqi, nap
5. Domain for 1fds:
  - Domain d1fdsa_: 1fds A: [29838]
    complexed with est
6. Domain for 1fdt:
  - Domain d1fdta_: 1fdt A: [29841]
    complexed with est, nap, so4
7. Domains for 1fdu:
  1. Domain d1fdua_: 1fdu A: [29848]
    complexed with est, nap, so4; mutant
  2. Domain d1fdub_: 1fdu B: [29849]
    complexed with est, nap, so4; mutant
  3. Domain d1fduc_: 1fdu C: [29850]
    complexed with est, nap, so4; mutant
  4. Domain d1fdud_: 1fdu D: [29851]
    complexed with est, nap, so4; mutant
8. Domains for 1fdv:
  1. Domain d1fdva_: 1fdv A: [29852]
    complexed with nad, so4; mutant
  2. Domain d1fdvb_: 1fdv B: [29853]
    complexed with nad, so4; mutant
  3. Domain d1fdvc_: 1fdv C: [29854]
    complexed with nad, so4; mutant
  4. Domain d1fdvd_: 1fdv D: [29855]
    complexed with nad, so4; mutant
9. Domain for 1fdw:
  - Domain d1fdwa_: 1fdw A: [29845]
    complexed with est; mutant
10. Domain for 1i5r:
  - Domain d1i5ra_: 1i5r A: [83668]
    complexed with gol, hyc
11. Domain for 1iol:
  - Domain d1iola_: 1iol A: [29842]
    complexed with est
12. Domain for 1jtv:
  - Domain d1jtva_: 1jtv A: [84230]
    complexed with gol, tes
13. Domain for 1qyv:
  - Domain d1qyva_: 1qyv A: [104659]
    complexed with gol, nap
14. Domain for 1qyw:
  - Domain d1qywa_: 1qyw A: [104660]
    complexed with 5sd, gol, nap
15. Domain for 1qyx:
  - Domain d1qyxa_: 1qyx A: [104661]
    complexed with asd, gol, nap
16. Domain for 3dey:
  - Domain d3deyx_: 3dey X: [209121]
    automated match to d1jtva_
    complexed with dht, gol
17. Domain for 3dhe:
  - Domain d3dhea_: 3dhe A: [29844]
    complexed with and
18. Domain for 3hb4:
  - Domain d3hb4x_: 3hb4 X: [210960]
    automated match to d1jtva_
    complexed with e2b
19. Domain for 3hb5:
  - Domain d3hb5x_: 3hb5 X: [210961]
    automated match to d1jtva_
    complexed with e2b, nap
20. Domain for 3klm:
  - Domain d3klmx_: 3klm X: [212413]
    automated match to d1fdsa_
    complexed with dht, gol
21. Domain for 3klp:
  - Domain d3klpx_: 3klp X: [212414]
    automated match to d1jtva_
    complexed with b81
22. Domains for 3km0:
  1. Domain d3km0a_: 3km0 A: [212415]
    automated match to d1jtva_
    complexed with aom, nap
  2. Domain d3km0b_: 3km0 B: [212416]
    automated match to d1jtva_
    complexed with aom, nap

More info for Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases:

Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases first appeared (with stable ids) in SCOP 1.55
Protein Human estrogenic 17beta-hydroxysteroid dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOPe 2.07