SCOPe 2.08: Domain d4u6va_: 4u6v A:

Lineage for d4u6va_ (4u6v A:)

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.6: Leukocidin-like [56958] (1 superfamily)
   subunit fold contains beta-sandwich of Ig-like (greek-key) topology and a beta-ribbon arm that forms an oligomeric transmembrane barrel

4. Superfamily f.6.1: Leukocidin-like [56959] (3 families)

5. Family f.6.1.1: Leukocidin (pore-forming toxin) [56960] (5 proteins)
   heptameric fold contains barrel (n=14, S=14) formed by beta-ribbon arms, one from each subunit
   automatically mapped to Pfam PF07968

6. Protein Alpha-hemolysin [56961] (2 species)

7. Species Staphylococcus aureus [TaxId:548473] [259724] (1 PDB entry)

8. Domain d4u6va_: 4u6v A: [259725]
   Other proteins in same PDB: d4u6vh_, d4u6vk_, d4u6vl1, d4u6vl2, d4u6vm1, d4u6vm2
   automated match to d7ahla_
   complexed with so4

Details for d4u6va_

PDB Entry: 4u6v, 2.56 Å

PDB Description: Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody

PDB Compounds: (A:) alpha-hemolysin

SCOPe Domain Sequences for d4u6va_:

Sequence, based on SEQRES records:

>d4u6va_ f.6.1.1 (A:) Alpha-hemolysin {Staphylococcus aureus [TaxId: 548473]}
tdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkgtiagqyrvysee
ganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeymstltygfngnvtgddtgk
iggliganvsightlkyvqpdfktilesptdkkvgwkvifnnmvnqnwgpydrdswnpvy
gnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkaskqqtnidviyer
vrddyqlhwtstnwkgtntkdkwidrsserykidwekeemtn

Sequence, based on observed residues (ATOM records):

>d4u6va_ f.6.1.1 (A:) Alpha-hemolysin {Staphylococcus aureus [TaxId: 548473]}
tdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkgtiagqyrvysee
ganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeymstltygfngnvtgganvs
ightlkyvqpdfktilesptdkkvgwkvifnnmvnqnwgpydrdswnpvygnqlfmktrn
gsmkaadnfldpnkassllssgfspdfatvitmdrkaskqqtnidviyervrddyqlhwt
stnwkgtntkdkwidrsserykidwekeemtn

Timeline for d4u6va_:

• d4u6va_ first appeared in SCOPe 2.04
  
• d4u6va_ appears in SCOPe 2.07