SCOPe 2.08: Domain d4f1sa4: 4f1s A:726-1091

Lineage for d4f1sa4 (4f1s A:726-1091)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (2 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56174] (78 PDB entries)

8. Domain d4f1sa4: 4f1s A:726-1091 [251866]
   Other proteins in same PDB: d4f1sa1, d4f1sa2, d4f1sa3
   automated match to d1e7ua4
   complexed with f1s, so4

Details for d4f1sa4

PDB Entry: 4f1s, 3 Å

PDB Description: Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine-sulfonamide inhibitor

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4f1sa4:

Sequence, based on SEQRES records:

>d4f1sa4 d.144.1.4 (A:726-1091) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflhlv

Sequence, based on observed residues (ATOM records):

>d4f1sa4 d.144.1.4 (A:726-1091) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsadvssqvisqlkqklenlqnsqlpesfrvpyd
pglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqil
rimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvggafkdevlnhw
lkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfgkerv
pfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpqlt
skedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlv

Timeline for d4f1sa4:

• d4f1sa4 first appeared in SCOPe 2.04
  
• d4f1sa4 appears in SCOPe 2.07