SCOPe 2.08: Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain

Lineage for Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (2 proteins)

Proteins:

1. mTOR kinase domain [346108] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [346385] (1 PDB entry)

2. Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [56174] (78 PDB entries)

   2. Species Pig (Sus scrofa) [TaxId:9823] [56173] (6 PDB entries)

More info for Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain

Timeline for Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain:

• Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain first appeared (with stable ids) in SCOP 1.55
  
• Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain appears in SCOPe 2.07