SCOPe 2.08: Domain d4f1sa2: 4f1s A:352-522

Lineage for d4f1sa2 (4f1s A:352-522)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.7: C2 domain-like [49561] (5 superfamilies)
   sandwich; 8 strands in 2 sheets; greek-key

4. Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (4 families)
   two constituent families are related by circular permutation

5. Family b.7.1.1: PLC-like (P variant) [49563] (12 proteins)

6. Protein Phoshoinositide 3-kinase (PI3K) [49570] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49572] (70 PDB entries)

8. Domain d4f1sa2: 4f1s A:352-522 [251864]
   Other proteins in same PDB: d4f1sa1, d4f1sa3, d4f1sa4
   automated match to d1e8wa2
   complexed with f1s, so4

Details for d4f1sa2

PDB Entry: 4f1s, 3 Å

PDB Description: Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine-sulfonamide inhibitor

PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4f1sa2:

Sequence, based on SEQRES records:

>d4f1sa2 b.7.1.1 (A:352-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
vslwdcdrkfrvkirgidipvlprntdltvfveaniqhgqqvlcqrrtspkpfteevlwn
vwlefsikikdlpkgallnlqiycgkapalsskasaespsseskgkvqllyyvnlllidh
rfllrrgeyvlhmwqisgkgedqgsfnadkltsatnpdkensmsisilldn

Sequence, based on observed residues (ATOM records):

>d4f1sa2 b.7.1.1 (A:352-522) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
vslwdcdrkfrvkirgidipvldltvfveaniqhgqqvlcqrrtspkpfteevlwnvwle
fsikikdlpkgallnlqiycgkvqllyyvnlllidhrfllrrgeyvlhmwqissfnadkl
tsatnpdkensmsisilldn

Timeline for d4f1sa2:

• d4f1sa2 first appeared in SCOPe 2.04
  
• d4f1sa2 appears in SCOPe 2.07