Lineage for d4f1sa4 (4f1s A:726-1091)

  1. Root: SCOPe 2.04
  2. 1631855Class d: Alpha and beta proteins (a+b) [53931] (380 folds)
  3. 1671717Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1671718Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1671724Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (1 protein)
  6. 1671725Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)
  7. 1671726Species Human (Homo sapiens) [TaxId:9606] [56174] (57 PDB entries)
  8. 1671749Domain d4f1sa4: 4f1s A:726-1091 [251866]
    Other proteins in same PDB: d4f1sa1, d4f1sa2, d4f1sa3
    automated match to d1e7ua4
    complexed with f1s, so4

Details for d4f1sa4

PDB Entry: 4f1s (more details), 3 Å

PDB Description: Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine-sulfonamide inhibitor
PDB Compounds: (A:) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d4f1sa4:

Sequence, based on SEQRES records: (download)

>d4f1sa4 d.144.1.4 (A:726-1091) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflhlv

Sequence, based on observed residues (ATOM records): (download)

>d4f1sa4 d.144.1.4 (A:726-1091) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsadvssqvisqlkqklenlqnsqlpesfrvpyd
pglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqil
rimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvggafkdevlnhw
lkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfgkerv
pfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpqlt
skedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlv

SCOPe Domain Coordinates for d4f1sa4:

Click to download the PDB-style file with coordinates for d4f1sa4.
(The format of our PDB-style files is described here.)

Timeline for d4f1sa4: