SCOPe 2.08: Domain d4oq5e1: 4oq5 E:174-322

Lineage for d4oq5e1 (4oq5 E:174-322)

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein EAT/MCL-1 (Myeloid cell leukemia sequence 1) [118212] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [188549] (62 PDB entries)

8. Domain d4oq5e1: 4oq5 E:174-322 [240723]
   Other proteins in same PDB: d4oq5a2, d4oq5b2, d4oq5c2, d4oq5d2, d4oq5e2, d4oq5f2
   automated match to d4oq5b_
   complexed with 2uu

Details for d4oq5e1

PDB Entry: 4oq5, 2.86 Å

PDB Description: Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid

PDB Compounds: (E:) Induced myeloid leukemia cell differentiation protein Mcl-1

SCOPe Domain Sequences for d4oq5e1:

Sequence; same for both SEQRES and ATOM records:

>d4oq5e1 f.1.4.1 (E:174-322) EAT/MCL-1 (Myeloid cell leukemia sequence 1) {Human (Homo sapiens) [TaxId: 9606]}
lyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgmlr
kldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaes
itdvlvrtkrdwlvkqrgwdgfveffhve

Timeline for d4oq5e1:

• d4oq5e1 first appeared in SCOPe 2.04, called d4oq5e_
  
• d4oq5e1 appears in SCOPe 2.07