PDB entry 4oq5

View 4oq5 on RCSB PDB site
Description: Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid
Class: apoptosis/inhibitor
Keywords: APOPTOSIS-INHIBITOR complex
Deposited on 2014-02-07, released 2014-03-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-03-12, with a file datestamp of 2014-03-07.
Experiment type: XRAY
Resolution: 2.86 Å
R-factor: 0.2
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (10-End)
      • expression tag (8-9)
    Domains in SCOPe 2.08: d4oq5a1, d4oq5a2
  • Chain 'B':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (10-End)
      • expression tag (8-9)
    Domains in SCOPe 2.08: d4oq5b1, d4oq5b2
  • Chain 'C':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (10-End)
      • expression tag (8-9)
    Domains in SCOPe 2.08: d4oq5c1, d4oq5c2
  • Chain 'D':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (10-End)
      • expression tag (8-9)
    Domains in SCOPe 2.08: d4oq5d1, d4oq5d2
  • Chain 'E':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (10-End)
      • expression tag (8-9)
    Domains in SCOPe 2.08: d4oq5e1, d4oq5e2
  • Chain 'F':
    Compound: Induced myeloid leukemia cell differentiation protein Mcl-1
    Species: Homo sapiens [TaxId:9606]
    Gene: MCL1, BCL2L3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07820 (10-End)
      • expression tag (8-9)
    Domains in SCOPe 2.08: d4oq5f1, d4oq5f2
  • Heterogens: 2UU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4oq5A (A:)
gtlvprgsmdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrn
hetafqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinq
escieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedleg

    Sequence, based on observed residues (ATOM records): (download) 
    >4oq5A (A:)
mdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrvtlisfgafvakhlktinqescieplae
sitdvlvrtkrdwlvkqrgwdgfveffhve

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4oq5B (B:)
gtlvprgsmdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrn
hetafqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinq
escieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedleg

    Sequence, based on observed residues (ATOM records): (download) 
    >4oq5B (B:)
mdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhve

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4oq5C (C:)
gtlvprgsmdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrn
hetafqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinq
escieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedleg

    Sequence, based on observed residues (ATOM records): (download) 
    >4oq5C (C:)
mdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffh

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4oq5D (D:)
gtlvprgsmdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrn
hetafqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinq
escieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedleg

    Sequence, based on observed residues (ATOM records): (download) 
    >4oq5D (D:)
mdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffh

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4oq5E (E:)
gtlvprgsmdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrn
hetafqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinq
escieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedleg

    Sequence, based on observed residues (ATOM records): (download) 
    >4oq5E (E:)
mdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhve

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4oq5F (F:)
gtlvprgsmdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrn
hetafqgmlrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinq
escieplaesitdvlvrtkrdwlvkqrgwdgfveffhvedleg

    Sequence, based on observed residues (ATOM records): (download) 
    >4oq5F (F:)
mdlyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffh