SCOPe 2.08: Family f.1.4.1: Bcl-2 inhibitors of programmed cell death

Lineage for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

Proteins:

1. Apoptosis regulator Bcl-w [90103] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [90104] (3 PDB entries)

2. Apoptosis regulator Bcl-xL [56856] (3 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [56857] (51 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [103423] (9 PDB entries)

   3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [56858] (1 PDB entry)

3. Apoptosis regulator ced-9 [103424] (1 species)

   • Species Nematode (Caenorhabditis elegans) [TaxId:6239] [103425] (2 PDB entries)
     Uniprot P41958 74-237

4. Bcl-2 [64524] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [64525] (18 PDB entries)

5. Bcl-2 homolog [75637] (1 species)

   • Species Kaposi's sarcoma-associated herpesvirus [TaxId:37296] [75638] (1 PDB entry)

6. Bcl-2 homolog V-bcl-2 [144081] (1 species)

   • Species Murid herpesvirus 4 [TaxId:33708] [144082] (3 PDB entries)
     Uniprot P89884 6-136

7. Early antigen protein R [103426] (1 species)

   • Species Epstein-Barr virus [TaxId:10376] [103427] (1 PDB entry)

8. EAT/MCL-1 (Myeloid cell leukemia sequence 1) [118212] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [188549] (62 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [118213] (6 PDB entries)
      Uniprot P97287 152-308

9. Proapoptotic molecule Bax [56862] (3 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [56863] (7 PDB entries)

   2. Species Ictalurus punctatus [TaxId:7998] [354102] (1 PDB entry)

   3. Species Mouse (Mus musculus) [TaxId:10090] [354174] (1 PDB entry)

10. Proapoptotic molecule Bid [56859] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [56860] (1 PDB entry)

    2. Species Mouse (Mus musculus) [TaxId:10090] [56861] (1 PDB entry)

11. automated matches [190236] (3 species)
    not a true protein

    1. Species Human (Homo sapiens) [TaxId:9606] [188722] (26 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [187004] (1 PDB entry)

    3. Species Nematode (Caenorhabditis elegans) [TaxId:6239] [255025] (1 PDB entry)

More info for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death

Timeline for Family f.1.4.1: Bcl-2 inhibitors of programmed cell death:

• Family f.1.4.1: Bcl-2 inhibitors of programmed cell death first appeared (with stable ids) in SCOP 1.55
  
• Family f.1.4.1: Bcl-2 inhibitors of programmed cell death appears in SCOPe 2.07