Lineage for d3dbrf1 (3dbr F:12-441)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2149982Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
  4. 2149983Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families) (S)
    transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
    the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds
  5. 2149990Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (3 protein domains)
    the common fold is elaborated with additional (sub)domains
  6. 2150022Protein UBA3 [89764] (1 species)
    a subunit of the heterodimeric E1 enzyme for NEDD8; contains an all-alpha insert subdomain of the FF-like fold (residues 210-288) and an extra C-terminal alpha+beta subdomain (partly disordered)
  7. 2150023Species Human (Homo sapiens) [TaxId:9606] [89765] (12 PDB entries)
    Uniprot Q8TBC4 33-458
  8. 2150047Domain d3dbrf1: 3dbr F:12-441 [239204]
    Other proteins in same PDB: d3dbra_, d3dbrb2, d3dbrc_, d3dbrd2, d3dbre_, d3dbrf2, d3dbrg_, d3dbrh2, d3dbri1, d3dbri2, d3dbrj1, d3dbrj2, d3dbrk1, d3dbrk2, d3dbrl1, d3dbrl2
    automated match to d3dbhb_
    complexed with zn

Details for d3dbrf1

PDB Entry: 3dbr (more details), 3.05 Å

PDB Description: structural dissection of a gating mechanism preventing misactivation of ubiquitin by nedd8's e1 (appbp1-uba3arg190gln-nedd8ala72arg)
PDB Compounds: (F:) NEDD8-activating enzyme E1 catalytic subunit

SCOPe Domain Sequences for d3dbrf1:

Sequence; same for both SEQRES and ATOM records: (download)

>d3dbrf1 c.111.1.2 (F:12-441) UBA3 {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3dbrf1:

Click to download the PDB-style file with coordinates for d3dbrf1.
(The format of our PDB-style files is described here.)

Timeline for d3dbrf1: