SCOPe 2.08: Structural Classification of Proteins

PDB entry 3dbr

View 3dbr on RCSB PDB site
Description: Structural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8's E1 (APPBP1-UBA3Arg190Gln-NEDD8Ala72Arg)
Class: Cell Cycle
Keywords: cell cycle, activating enzyme, Apoptosis, Membrane, Ubl conjugation pathway, ATP-binding, Ligase, Nucleotide-binding, Polymorphism, Nucleus
Deposited on 2008-06-02, released 2008-08-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-07-14, with a file datestamp of 2009-07-10.
Experiment type: XRAY
Resolution: 3.05 Å
R-factor: 0.23
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: NEDD8-activating enzyme E1 regulatory subunit
Species: Homo sapiens [TaxId:9606]
Gene: NAE1, APPBP1
Database cross-references and differences (RAF-indexed):
- Uniprot Q13564 (Start-530)
Domains in SCOPe 2.08: d3dbra_
Chain 'B':
Compound: NEDD8-activating enzyme E1 catalytic subunit
Species: Homo sapiens [TaxId:9606]
Gene: UBA3, UBE1C
Database cross-references and differences (RAF-indexed):
- Uniprot Q8TBC4 (3-433)
  - expression tag (2)
  - engineered (181)
  - engineered (207)
Domains in SCOPe 2.08: d3dbrb1, d3dbrb2
Chain 'C':
Compound: NEDD8-activating enzyme E1 regulatory subunit
Species: Homo sapiens [TaxId:9606]
Gene: NAE1, APPBP1
Database cross-references and differences (RAF-indexed):
- Uniprot Q13564 (Start-530)
Domains in SCOPe 2.08: d3dbrc_
Chain 'D':
Compound: NEDD8-activating enzyme E1 catalytic subunit
Species: Homo sapiens [TaxId:9606]
Gene: UBA3, UBE1C
Database cross-references and differences (RAF-indexed):
- Uniprot Q8TBC4 (3-End)
  - expression tag (2)
  - engineered (181)
  - engineered (207)
Domains in SCOPe 2.08: d3dbrd1, d3dbrd2
Chain 'E':
Compound: NEDD8-activating enzyme E1 regulatory subunit
Species: Homo sapiens [TaxId:9606]
Gene: NAE1, APPBP1
Database cross-references and differences (RAF-indexed):
- Uniprot Q13564 (Start-530)
Domains in SCOPe 2.08: d3dbre_
Chain 'F':
Compound: NEDD8-activating enzyme E1 catalytic subunit
Species: Homo sapiens [TaxId:9606]
Gene: UBA3, UBE1C
Database cross-references and differences (RAF-indexed):
- Uniprot Q8TBC4 (3-End)
  - expression tag (2)
  - engineered (181)
  - engineered (207)
Domains in SCOPe 2.08: d3dbrf1, d3dbrf2
Chain 'G':
Compound: NEDD8-activating enzyme E1 regulatory subunit
Species: Homo sapiens [TaxId:9606]
Gene: NAE1, APPBP1
Database cross-references and differences (RAF-indexed):
- Uniprot Q13564 (Start-530)
Domains in SCOPe 2.08: d3dbrg_
Chain 'H':
Compound: NEDD8-activating enzyme E1 catalytic subunit
Species: Homo sapiens [TaxId:9606]
Gene: UBA3, UBE1C
Database cross-references and differences (RAF-indexed):
- Uniprot Q8TBC4 (3-End)
  - expression tag (2)
  - engineered (181)
  - engineered (207)
Domains in SCOPe 2.08: d3dbrh1, d3dbrh2
Chain 'I':
Compound: nedd8
Species: Homo sapiens [TaxId:9606]
Gene: NEDD8
Database cross-references and differences (RAF-indexed):
- Uniprot Q15843 (12-87)
  - expression tag (2-8)
  - expression tag (10-11)
  - engineered (83)
Domains in SCOPe 2.08: d3dbri1, d3dbri2
Chain 'J':
Compound: nedd8
Species: Homo sapiens [TaxId:9606]
Gene: NEDD8
Database cross-references and differences (RAF-indexed):
- Uniprot Q15843 (12-87)
  - expression tag (11)
  - engineered (83)
Domains in SCOPe 2.08: d3dbrj1, d3dbrj2
Chain 'K':
Compound: nedd8
Species: Homo sapiens [TaxId:9606]
Gene: NEDD8
Database cross-references and differences (RAF-indexed):
- Uniprot Q15843 (12-87)
  - expression tag (11)
  - engineered (83)
Domains in SCOPe 2.08: d3dbrk1, d3dbrk2
Chain 'L':
Compound: nedd8
Species: Homo sapiens [TaxId:9606]
Gene: NEDD8
Database cross-references and differences (RAF-indexed):
- Uniprot Q15843 (12-87)
  - expression tag (10-11)
  - engineered (83)
Domains in SCOPe 2.08: d3dbrl1, d3dbrl2
Heterogens: ZN

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3dbrA (A:)
gsmaqlgkllkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsft
iidgnqvsgedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndps
ffcrftvvvatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdn
aledlrldkpfpelrehfqsydldhmekkdhshtpwiviiakylaqwysetngripktyk
ekedfrdlirqgilkpedeenfeeaiknvntalnttqipssiedifnddrcinitkqtps
fwilaralkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvak
llqsigqapesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdnei
vlylmlravdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefc
rygaaephtiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql