SCOPe 2.07: Species: Human (Homo sapiens) [TaxId: 9606]

Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

Root: SCOPe 2.07
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest

Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families)

(S)

transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds

Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (3 protein domains)
the common fold is elaborated with additional (sub)domains

Protein UBA3 [89764] (1 species)
a subunit of the heterodimeric E1 enzyme for NEDD8; contains an all-alpha insert subdomain of the FF-like fold (residues 210-288) and an extra C-terminal alpha+beta subdomain (partly disordered)

Species Human (Homo sapiens) [TaxId:9606] [89765] (12 PDB entries)
Uniprot Q8TBC4 33-458

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

Domain(s) for 1r4m:
1. Domain d1r4mb_: 1r4m B: [97000]
  Other proteins in same PDB: d1r4ma_, d1r4mc_, d1r4me_, d1r4mg_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
  complexed with zn
2. Domain d1r4md_: 1r4m D: [97002]
  Other proteins in same PDB: d1r4ma_, d1r4mc_, d1r4me_, d1r4mg_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
  complexed with zn
3. Domain d1r4mf_: 1r4m F: [97004]
  Other proteins in same PDB: d1r4ma_, d1r4mc_, d1r4me_, d1r4mg_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
  complexed with zn
4. Domain d1r4mh_: 1r4m H: [97006]
  Other proteins in same PDB: d1r4ma_, d1r4mc_, d1r4me_, d1r4mg_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
  complexed with zn
Domain(s) for 1r4n:
1. Domain d1r4nb_: 1r4n B: [97012]
  Other proteins in same PDB: d1r4na_, d1r4nc_, d1r4ne_, d1r4ng_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
  complexed with atp, zn
2. Domain d1r4nd_: 1r4n D: [97014]
  Other proteins in same PDB: d1r4na_, d1r4nc_, d1r4ne_, d1r4ng_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
  complexed with atp, zn
3. Domain d1r4nf_: 1r4n F: [97016]
  Other proteins in same PDB: d1r4na_, d1r4nc_, d1r4ne_, d1r4ng_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
  complexed with atp, zn
4. Domain d1r4nh_: 1r4n H: [97018]
  Other proteins in same PDB: d1r4na_, d1r4nc_, d1r4ne_, d1r4ng_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
  complexed with atp, zn
Domain(s) for 1tt5:
1. Domain d1tt5b1: 1tt5 B:12-1008 [107292]
  Other proteins in same PDB: d1tt5a_, d1tt5b2, d1tt5c_
  complexed with zn
2. Domain d1tt5d_: 1tt5 D: [107294]
  Other proteins in same PDB: d1tt5a_, d1tt5b2, d1tt5c_
  complexed with zn
Domain(s) for 1y8x:
- Domain d1y8xb1: 1y8x B:349-440 [144607]
  Other proteins in same PDB: d1y8xa1, d1y8xa2
  C-terminal, E2 binding domain only; (this domain belongs to Pfam PF08825)
Domain(s) for 1yov:
1. Domain d1yovb_: 1yov B: [123786]
  Other proteins in same PDB: d1yova_, d1yovc_
  automated match to d1ngvb_
  complexed with zn
2. Domain d1yovd_: 1yov D: [123788]
  Other proteins in same PDB: d1yova_, d1yovc_
  automated match to d1ngvb_
  complexed with zn
Domain(s) for 2lq7:
- Domain d2lq7a1: 2lq7 A:348-442 [242963]
  Other proteins in same PDB: d2lq7a2
  automated match to d3fn1a_
Domain(s) for 2nvu:
- Domain d2nvub1: 2nvu B:2012-2441 [138661]
  Other proteins in same PDB: d2nvua_, d2nvub2, d2nvuc1, d2nvui_, d2nvuj_
  automatically matched to d1ngvb_
  complexed with atp, mg, zn

Domain(s) for 3dbh:

Domain d3dbhb1: 3dbh B:12-442 [161640]
Other proteins in same PDB: d3dbha_, d3dbhb2, d3dbhc_, d3dbhd2, d3dbhe_, d3dbhf2, d3dbhg_, d3dbhh2, d3dbhi2, d3dbhi3, d3dbhj_, d3dbhk_, d3dbhl_
automated match to d1r4mb_
complexed with zn

Domain d3dbhd1: 3dbh D:12-442 [161641]
Other proteins in same PDB: d3dbha_, d3dbhb2, d3dbhc_, d3dbhd2, d3dbhe_, d3dbhf2, d3dbhg_, d3dbhh2, d3dbhi2, d3dbhi3, d3dbhj_, d3dbhk_, d3dbhl_
automated match to d1r4mb_
complexed with zn

Domain d3dbhf1: 3dbh F:12-441 [161642]
Other proteins in same PDB: d3dbha_, d3dbhb2, d3dbhc_, d3dbhd2, d3dbhe_, d3dbhf2, d3dbhg_, d3dbhh2, d3dbhi2, d3dbhi3, d3dbhj_, d3dbhk_, d3dbhl_
automated match to d1r4mb_
complexed with zn

Domain d3dbhh1: 3dbh H:12-441 [161643]
Other proteins in same PDB: d3dbha_, d3dbhb2, d3dbhc_, d3dbhd2, d3dbhe_, d3dbhf2, d3dbhg_, d3dbhh2, d3dbhi2, d3dbhi3, d3dbhj_, d3dbhk_, d3dbhl_
automated match to d1r4mb_
complexed with zn

Domain(s) for 3dbl:

Domain d3dblb2: 3dbl B:12-442 [157474]
Other proteins in same PDB: d3dbla_, d3dblb3, d3dblc_, d3dbld3, d3dble_, d3dblf3, d3dblg_, d3dblh3, d3dbli2, d3dbli3, d3dblj_, d3dblk_, d3dbll_
automated match to d1r4mb_
complexed with zn

Domain d3dbld2: 3dbl D:12-442 [157476]
Other proteins in same PDB: d3dbla_, d3dblb3, d3dblc_, d3dbld3, d3dble_, d3dblf3, d3dblg_, d3dblh3, d3dbli2, d3dbli3, d3dblj_, d3dblk_, d3dbll_
automated match to d1r4mb_
complexed with zn

Domain d3dblf2: 3dbl F:12-441 [157478]
Other proteins in same PDB: d3dbla_, d3dblb3, d3dblc_, d3dbld3, d3dble_, d3dblf3, d3dblg_, d3dblh3, d3dbli2, d3dbli3, d3dblj_, d3dblk_, d3dbll_
automated match to d1r4mb_
complexed with zn

Domain d3dblh2: 3dbl H:12-441 [157480]
Other proteins in same PDB: d3dbla_, d3dblb3, d3dblc_, d3dbld3, d3dble_, d3dblf3, d3dblg_, d3dblh3, d3dbli2, d3dbli3, d3dblj_, d3dblk_, d3dbll_
automated match to d1r4mb_
complexed with zn

Domain(s) for 3dbr:

Domain d3dbrb1: 3dbr B:12-442 [239202]
Other proteins in same PDB: d3dbra_, d3dbrb2, d3dbrc_, d3dbrd2, d3dbre_, d3dbrf2, d3dbrg_, d3dbrh2, d3dbri1, d3dbri2, d3dbrj1, d3dbrj2, d3dbrk1, d3dbrk2, d3dbrl1, d3dbrl2
automated match to d3dbhb_
complexed with zn

Domain d3dbrd1: 3dbr D:12-441 [239203]
Other proteins in same PDB: d3dbra_, d3dbrb2, d3dbrc_, d3dbrd2, d3dbre_, d3dbrf2, d3dbrg_, d3dbrh2, d3dbri1, d3dbri2, d3dbrj1, d3dbrj2, d3dbrk1, d3dbrk2, d3dbrl1, d3dbrl2
automated match to d3dbhb_
complexed with zn

Domain d3dbrf1: 3dbr F:12-441 [239204]
Other proteins in same PDB: d3dbra_, d3dbrb2, d3dbrc_, d3dbrd2, d3dbre_, d3dbrf2, d3dbrg_, d3dbrh2, d3dbri1, d3dbri2, d3dbrj1, d3dbrj2, d3dbrk1, d3dbrk2, d3dbrl1, d3dbrl2
automated match to d3dbhb_
complexed with zn

Domain d3dbrh1: 3dbr H:12-441 [239205]
Other proteins in same PDB: d3dbra_, d3dbrb2, d3dbrc_, d3dbrd2, d3dbre_, d3dbrf2, d3dbrg_, d3dbrh2, d3dbri1, d3dbri2, d3dbrj1, d3dbrj2, d3dbrk1, d3dbrk2, d3dbrl1, d3dbrl2
automated match to d3dbhb_
complexed with zn

Domain(s) for 3fn1:
- Domain d3fn1a_: 3fn1 A: [210014]
  Other proteins in same PDB: d3fn1b_
  automated match to d1y8xb1
Domain(s) for 3gzn:
1. Domain d3gznb_: 3gzn B: [246397]
  Other proteins in same PDB: d3gzna_, d3gznc_, d3gzni1, d3gzni2, d3gznj1, d3gznj2
  automated match to d3dbhb_
  complexed with b39, zn
2. Domain d3gznd_: 3gzn D: [246399]
  Other proteins in same PDB: d3gzna_, d3gznc_, d3gzni1, d3gzni2, d3gznj1, d3gznj2
  automated match to d3dbhb_
  complexed with b39, zn

More info for Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 UBA3

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 UBA3:

Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 UBA3 first appeared in SCOP 1.65
Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 UBA3 appears in SCOPe 2.06