Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.08
  2. 2826024Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2921020Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
  4. 2921021Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families) (S)
    transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
    the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds
  5. 2921028Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (3 proteins)
    the common fold is elaborated with additional (sub)domains
  6. 2921060Protein UBA3 [89764] (1 species)
    a subunit of the heterodimeric E1 enzyme for NEDD8; contains an all-alpha insert subdomain of the FF-like fold (residues 210-288) and an extra C-terminal alpha+beta subdomain (partly disordered)
  7. 2921061Species Human (Homo sapiens) [TaxId:9606] [89765] (12 PDB entries)
    Uniprot Q8TBC4 33-458

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 1r4m:
    1. 2921079Domain d1r4mb_: 1r4m B: [97000]
      Other proteins in same PDB: d1r4ma_, d1r4mc_, d1r4me_, d1r4mg_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
    2. 2921080Domain d1r4md_: 1r4m D: [97002]
      Other proteins in same PDB: d1r4ma_, d1r4mc_, d1r4me_, d1r4mg_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
    3. 2921081Domain d1r4mf_: 1r4m F: [97004]
      Other proteins in same PDB: d1r4ma_, d1r4mc_, d1r4me_, d1r4mg_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
    4. 2921082Domain d1r4mh_: 1r4m H: [97006]
      Other proteins in same PDB: d1r4ma_, d1r4mc_, d1r4me_, d1r4mg_, d1r4mi_, d1r4mj_, d1r4mk_, d1r4ml_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
  2. Domain(s) for 1r4n:
    1. 2921087Domain d1r4nb_: 1r4n B: [97012]
      Other proteins in same PDB: d1r4na_, d1r4nc_, d1r4ne_, d1r4ng_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
      complexed with atp, zn
      has additional subdomain(s) that are not in the common domain
    2. 2921088Domain d1r4nd_: 1r4n D: [97014]
      Other proteins in same PDB: d1r4na_, d1r4nc_, d1r4ne_, d1r4ng_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
      complexed with atp, zn
      has additional subdomain(s) that are not in the common domain
    3. 2921089Domain d1r4nf_: 1r4n F: [97016]
      Other proteins in same PDB: d1r4na_, d1r4nc_, d1r4ne_, d1r4ng_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
      complexed with atp, zn
      has additional subdomain(s) that are not in the common domain
    4. 2921090Domain d1r4nh_: 1r4n H: [97018]
      Other proteins in same PDB: d1r4na_, d1r4nc_, d1r4ne_, d1r4ng_, d1r4ni_, d1r4nj_, d1r4nk_, d1r4nl_
      complexed with atp, zn
      has additional subdomain(s) that are not in the common domain
  3. Domain(s) for 1tt5:
    1. 2921065Domain d1tt5b1: 1tt5 B:12-1008 [107292]
      Other proteins in same PDB: d1tt5a_, d1tt5b2, d1tt5c_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
    2. 2921066Domain d1tt5d_: 1tt5 D: [107294]
      Other proteins in same PDB: d1tt5a_, d1tt5b2, d1tt5c_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
  4. Domain(s) for 1y8x:
    • 2921064Domain d1y8xb1: 1y8x B:349-440 [144607]
      Other proteins in same PDB: d1y8xa1, d1y8xa2
      C-terminal, E2 binding domain only; (this domain belongs to Pfam PF08825)
      fragment; missing more than one-third of the common structure and/or sequence
      has additional subdomain(s) that are not in the common domain
  5. Domain(s) for 1yov:
    1. 2921062Domain d1yovb_: 1yov B: [123786]
      Other proteins in same PDB: d1yova_, d1yovc_
      automated match to d1ngvb_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
    2. 2921063Domain d1yovd_: 1yov D: [123788]
      Other proteins in same PDB: d1yova_, d1yovc_
      automated match to d1ngvb_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
  6. Domain(s) for 2lq7:
    • 2921091Domain d2lq7a1: 2lq7 A:348-442 [242963]
      Other proteins in same PDB: d2lq7a2
      automated match to d3fn1a_
      fragment; missing more than one-third of the common structure and/or sequence
      has additional subdomain(s) that are not in the common domain
  7. Domain(s) for 2nvu:
  8. Domain(s) for 3dbh:
    1. 2921067Domain d3dbhb1: 3dbh B:12-442 [161640]
      Other proteins in same PDB: d3dbha_, d3dbhb2, d3dbhc_, d3dbhd2, d3dbhe_, d3dbhf2, d3dbhg_, d3dbhh2, d3dbhi2, d3dbhi3, d3dbhj_, d3dbhk_, d3dbhl_
      automated match to d1r4mb_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
    2. 2921068Domain d3dbhd1: 3dbh D:12-442 [161641]
      Other proteins in same PDB: d3dbha_, d3dbhb2, d3dbhc_, d3dbhd2, d3dbhe_, d3dbhf2, d3dbhg_, d3dbhh2, d3dbhi2, d3dbhi3, d3dbhj_, d3dbhk_, d3dbhl_
      automated match to d1r4mb_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
    3. 2921069Domain d3dbhf1: 3dbh F:12-441 [161642]
      Other proteins in same PDB: d3dbha_, d3dbhb2, d3dbhc_, d3dbhd2, d3dbhe_, d3dbhf2, d3dbhg_, d3dbhh2, d3dbhi2, d3dbhi3, d3dbhj_, d3dbhk_, d3dbhl_
      automated match to d1r4mb_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
    4. 2921070Domain d3dbhh1: 3dbh H:12-441 [161643]
      Other proteins in same PDB: d3dbha_, d3dbhb2, d3dbhc_, d3dbhd2, d3dbhe_, d3dbhf2, d3dbhg_, d3dbhh2, d3dbhi2, d3dbhi3, d3dbhj_, d3dbhk_, d3dbhl_
      automated match to d1r4mb_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
  9. Domain(s) for 3dbl:
    1. 2921071Domain d3dblb2: 3dbl B:12-442 [157474]
      Other proteins in same PDB: d3dbla_, d3dblb3, d3dblc_, d3dbld3, d3dble_, d3dblf3, d3dblg_, d3dblh3, d3dbli2, d3dbli3, d3dblj_, d3dblk_, d3dbll_
      automated match to d1r4mb_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
    2. 2921072Domain d3dbld2: 3dbl D:12-442 [157476]
      Other proteins in same PDB: d3dbla_, d3dblb3, d3dblc_, d3dbld3, d3dble_, d3dblf3, d3dblg_, d3dblh3, d3dbli2, d3dbli3, d3dblj_, d3dblk_, d3dbll_
      automated match to d1r4mb_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
    3. 2921073Domain d3dblf2: 3dbl F:12-441 [157478]
      Other proteins in same PDB: d3dbla_, d3dblb3, d3dblc_, d3dbld3, d3dble_, d3dblf3, d3dblg_, d3dblh3, d3dbli2, d3dbli3, d3dblj_, d3dblk_, d3dbll_
      automated match to d1r4mb_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
    4. 2921074Domain d3dblh2: 3dbl H:12-441 [157480]
      Other proteins in same PDB: d3dbla_, d3dblb3, d3dblc_, d3dbld3, d3dble_, d3dblf3, d3dblg_, d3dblh3, d3dbli2, d3dbli3, d3dblj_, d3dblk_, d3dbll_
      automated match to d1r4mb_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
  10. Domain(s) for 3dbr:
    1. 2921083Domain d3dbrb1: 3dbr B:12-442 [239202]
      Other proteins in same PDB: d3dbra_, d3dbrb2, d3dbrc_, d3dbrd2, d3dbre_, d3dbrf2, d3dbrg_, d3dbrh2, d3dbri1, d3dbri2, d3dbrj1, d3dbrj2, d3dbrk1, d3dbrk2, d3dbrl1, d3dbrl2
      automated match to d3dbhb_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
    2. 2921084Domain d3dbrd1: 3dbr D:12-441 [239203]
      Other proteins in same PDB: d3dbra_, d3dbrb2, d3dbrc_, d3dbrd2, d3dbre_, d3dbrf2, d3dbrg_, d3dbrh2, d3dbri1, d3dbri2, d3dbrj1, d3dbrj2, d3dbrk1, d3dbrk2, d3dbrl1, d3dbrl2
      automated match to d3dbhb_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
    3. 2921085Domain d3dbrf1: 3dbr F:12-441 [239204]
      Other proteins in same PDB: d3dbra_, d3dbrb2, d3dbrc_, d3dbrd2, d3dbre_, d3dbrf2, d3dbrg_, d3dbrh2, d3dbri1, d3dbri2, d3dbrj1, d3dbrj2, d3dbrk1, d3dbrk2, d3dbrl1, d3dbrl2
      automated match to d3dbhb_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
    4. 2921086Domain d3dbrh1: 3dbr H:12-441 [239205]
      Other proteins in same PDB: d3dbra_, d3dbrb2, d3dbrc_, d3dbrd2, d3dbre_, d3dbrf2, d3dbrg_, d3dbrh2, d3dbri1, d3dbri2, d3dbrj1, d3dbrj2, d3dbrk1, d3dbrk2, d3dbrl1, d3dbrl2
      automated match to d3dbhb_
      complexed with zn
      has additional subdomain(s) that are not in the common domain
  11. Domain(s) for 3fn1:
    • 2921078Domain d3fn1a_: 3fn1 A: [210014]
      Other proteins in same PDB: d3fn1b_
      automated match to d1y8xb1
      fragment; missing more than one-third of the common structure and/or sequence
      has additional subdomain(s) that are not in the common domain
  12. Domain(s) for 3gzn:
    1. 2921076Domain d3gznb_: 3gzn B: [246397]
      Other proteins in same PDB: d3gzna_, d3gznc_, d3gzni1, d3gzni2, d3gznj1, d3gznj2
      automated match to d3dbhb_
      complexed with b39, zn
      has additional subdomain(s) that are not in the common domain
    2. 2921077Domain d3gznd_: 3gzn D: [246399]
      Other proteins in same PDB: d3gzna_, d3gznc_, d3gzni1, d3gzni2, d3gznj1, d3gznj2
      automated match to d3dbhb_
      complexed with b39, zn
      has additional subdomain(s) that are not in the common domain

More info for Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 UBA3

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.111.1.2 UBA3: