PDB entry 6cuu

View 6cuu on RCSB PDB site
Description: Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic Kanglemycin A
Class: transcription/dna/antibiotic
Keywords: RNA polymerase, Kanglemycin A, transcription inhibitor, TRANSCRIPTION, transcription-dna-antibiotic complex
Deposited on 2018-03-26, released 2018-07-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 2.99 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA-directed RNA polymerase subunit alpha
    Species: Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [TaxId:262724]
    Gene: rpoA, TT_C1300
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6cuua1, d6cuua2
  • Chain 'B':
    Compound: DNA-directed RNA polymerase subunit alpha
    Species: Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [TaxId:262724]
    Gene: rpoA, TT_C1300
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6cuub1, d6cuub2
  • Chain 'C':
    Compound: DNA-directed RNA polymerase subunit beta
    Species: Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [TaxId:262724]
    Gene: rpoB, TT_C1461
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q72HM5 (0-End)
      • conflict (957)
    Domains in SCOPe 2.08: d6cuuc_
  • Chain 'D':
    Compound: DNA-directed RNA polymerase subunit beta'
    Species: Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [TaxId:262724]
    Gene: rpoC, TT_C1460
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q72HM6
      • conflict (273)
      • conflict (1040)
      • conflict (1312)
    Domains in SCOPe 2.08: d6cuud_
  • Chain 'E':
    Compound: DNA-directed RNA polymerase subunit omega
    Species: Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [TaxId:262724]
    Gene: rpoZ, TT_C1196
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6cuue_
  • Chain 'F':
    Compound: RNA polymerase sigma factor SigA
    Species: Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [TaxId:262724]
    Gene: sigA, rpoD, TT_C0164
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6cuuf1, d6cuuf2, d6cuuf3
  • Chain 'G':
    Compound: DNA (5'-d(p*tp*gp*cp*ap*tp*cp*ap*gp*ap*gp*cp*cp*cp*ap*ap*ap*a)-3')
    Species: Bacillus subtilis [TaxId:1423]
  • Chain 'H':
    Compound: DNA (5'-d(*tp*ap*tp*ap*ap*tp*gp*gp*gp*ap*gp*cp*cp*tp*cp*tp*gp*ap*tp*gp*cp*a)-3')
    Species: Bacillus subtilis [TaxId:1423]
  • Heterogens: KNG, ZN, MG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6cuuA (A:)
mldsklkapvftvrtqgreygefvleplergfgvtlgnplrrillssipgtavtsvyied
vlhefstipgvkedvveiilnlkelvvrflnpslqtvtlllkaegpkevkardflpvadv
eimnpdlhiatleeggrlnmevrvdrgvgyvpaekhgikdrinaipvdavfspvrrvafq
vedtrlgqrtdldkltlriwtdgsvtplealnqaveilrehltyfsnpqaaavaapeeak
epeappeqeeeldlpleelglstrvlhslkeegiesvrallalnlkdlknipgigersle
eikealekkgftlke

    Sequence, based on observed residues (ATOM records): (download) 
    >6cuuA (A:)
sklkapvftvrtqgreygefvleplergfgvtlgnplrrillssipgtavtsvyiedvlh
efstipgvkedvveiilnlkelvvrflnpslqtvtlllkaegpkevkardflpvadveim
npdlhiatleeggrlnmevrvdrgvgyvpaekhgikdrinaipvdavfspvrrvafqved
trlgqrtdldkltlriwtdgsvtplealnqaveilrehltyfsnpqa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6cuuB (B:)
mldsklkapvftvrtqgreygefvleplergfgvtlgnplrrillssipgtavtsvyied
vlhefstipgvkedvveiilnlkelvvrflnpslqtvtlllkaegpkevkardflpvadv
eimnpdlhiatleeggrlnmevrvdrgvgyvpaekhgikdrinaipvdavfspvrrvafq
vedtrlgqrtdldkltlriwtdgsvtplealnqaveilrehltyfsnpqaaavaapeeak
epeappeqeeeldlpleelglstrvlhslkeegiesvrallalnlkdlknipgigersle
eikealekkgftlke

    Sequence, based on observed residues (ATOM records): (download) 
    >6cuuB (B:)
lkapvftvrtqgreygefvleplergfgvtlgnplrrillssipgtavtsvyiedvlhef
stipgvkedvveiilnlkelvvrflnpslqtvtlllkaegpkevkardflpvadveimnp
dlhiatleeggrlnmevrvdrgvgyvpaekhgikdrinaipvdavfspvrrvafqvedtr
lgqrtdldkltlriwtdgsvtplealnqaveilrehltyfsnp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6cuuC (C:)
meikrfgrireviplpplteiqvesyrralqadvppekrenvgiqaafretfpieeedkg
kgglvldfleyrlgeppfpqdecrekdltyqaplyarlqlihkdtglikedevflghipl
mtedgsfiingadrvivsqihrspgvyftpdparpgryiasiiplpkrgpwidlevepng
vvsmkvnkrkfplvlllrvlgydqetlarelgaygelvqglmdesvfamrpeealirlft
llrpgdppkrdkavayvygliadprrydlgeagrykaeeklgirlsgrtlarfedgefkd
evflptlrylfaltagvpghevddidhlgnrrirtvgelmtdqfrvglarlargvrerml
mgsedsltpaklvnsrpleaaireffsrsqlsqfkdetnplsslrhkrrisalgpggltr
eragfdvrdvhrthygricpvetpeganiglitslaayarvdelgfirtpyrrvvggvvt
devvymtateedrytiaqantplegnriaaervvarrkgepvivspeevefmdvspkqvf
svntnlipflehddanralmgsnmqtqavpliraqapvvmtgleervvrdslaalyaeed
gevakvdgnrivvryedgrlveyplrrfyrsnqgtaldqrprvvvgqrvrkgdlladgpa
sengflalgqnvlvaimpfdgynfedaiviseellkrdfytsihieryeieardtklgpe
ritrdiphlseaalrdldeegvvrigaevkpgdilvgrtsfkgeseptpeerllrsifge
kardvkdtslrvppgeggivvrtvrlrrgdpgvelkpgvrevvrvyvaqkrklqvgdkla
nrhgnkgvvakilpvedmphlpdgtpvdvilnplgvpsrmnlgqilethlglagyflgqr
yispifdgakepeikellaqafevyfgkrkgegfgvdkrevevlrraeklglvtpgktpe
eqlkelflqgkvvlydgrtgepiegpivvgqmfimklyhmvedkmharstgpyslitqqp
lggkaqfggqrfgemevwaleaygaahtlqemltlksddiegrnaayeaiikgedvpeps
vpesfrvlvkelqalaldvqtldekdnpvdifeglaskr

    Sequence, based on observed residues (ATOM records): (download) 
    >6cuuC (C:)
meikrfgrireviplpplteiqvesyrralqadvppekrenvgiqaafretfpieeglvl
dfleyrlgeppfpqdecrekdltyqaplyarlqlihkdtglikedevflghiplmtedgs
fiingadrvivsqihrspgvyftpdparpgryiasiiplpkrgpwidlevepngvvsmkv
nkrkfplvlllrvlgydqetlarelgaygelvqglmdesvfamrpeealirlftllrpgd
ppkrdkavayvygliadprrydlgeagrykaeeklgirlsgrtlarfedgefkdevflpt
lrylfaltagvpghevddidhlgnrrirtvgelmtdqfrvglarlargvrermlmgseds
ltpaklvnsrpleaaireffsrsqlsqfkdetnplsslrhkrrisalgpggltreragfd
vrdvhrthygricpvetpeganiglitslaayarvdelgfirtpyrrvvggvvtdevvym
tateedrytiaqantplegnriaaervvarrkgepvivspeevefmdvspkqvfsvntnl
ipflehddanralmgsnmqtqavpliraqapvvmtgleervvrdslaalyaeedgevakv
dgnrivvryedgrlveyplrrfyrsnqgtaldqrprvvvgqrvrkgdlladgpasengfl
algqnvlvaimpfdgynfedaiviseellkrdfytsihieryeieardtklgperitrdi
phlseaalrdldeegvvrigaevkpgdilvgrtsfkgeseptpeerllrsifgekardvk
dtslrvppgeggivvrtvrlrrgdpgvelkpgvrevvrvyvaqkrklqvgdklanrhgnk
gvvakilpvedmphlpdgtpvdvilnplgvpsrmnlgqilethlglagyflgqryispif
dgakepeikellaqafevyfgkrkgegfgvdkrevevlrraeklglvtpgktpeeqlkel
flqgkvvlydgrtgepiegpivvgqmfimklyhmvedkmharstgpyslitqqplggkaq
fggqrfgemevwaleaygaahtlqemltlksddiegrnaayeaiikgedvpepsvpesfr
vlvkelqalaldvqtldekdnpvdifeglask

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6cuuD (D:)
mkkevrkvrialaspekirswsygevekpetinyrtlkperdglfderifgpikdyecac
gkykrqrfegkvcercgvevtksivrryrmghielatpaahiwfvkdvpskigtlldlsa
teleqvlyfskyivldpkgailngvpvekrqlltdeeyrelrygkqetyplppgvdalvk
dgeevvkgqelapgvvsrldgvalyrfprrvrveyvkkeraglrlplaawvekeaykpge
ilaelpepylfraeeegvvelkeleegaflvlrredepvatyflpvgmtplvvhgeivek
gqplaeakgllrmprqvraaqveaeeegetvyltlflewtepkdyrvqphmnvvvpegar
veagdkivaaidpeeeviaeaegvvhlhepasilvvkarvypfeddvevstgdrvapgdv
ladggkvksdvygrvevdlvrnvvrvvesydidarmgaeaiqqllkeldlealekellee
mkhpsrarrakarkrlevvrafldsgnrpewmileavpvlppdlrpmvqvdggrfatsdl
ndlyrrlinrnnrlkkllaqgapeiiirnekrmlqeavdalldngrrgapvtnpgsdrpl
rsltdilsgkqgrfrqnllgkrvdysgrsvivvgpqlklhqcglpkrmalelfkpfllkk
meekgiapnvkaarrmlerqrdikdevwdaleevihgkvvllnraptlhrlgiqafqpvl
vegqsiqlhplvceafnadfdgdqmavhvplssfaqaeariqmlsahnllspasgeplak
psrdiilglyyitqvrkekkgaglefatpeealaahergevalnapikvagretsvgrlk
yvfanpdeallavahgivdlqdvvtvrymgkrletspgrilfarivaeavedekvaweli
qldvpqeknslkdlvyqaflrlgmektarlldalkyygftfsttsgitigiddavipeek
kqyleeadrkllqieqayemgfltdrerydqilqlwtettekvtqavfknfeenypfnpl
yvmaqsgargnpqqirqlcglrglmqkpsgetfevpvrssfregltvleyfisshgarkg
gadtalrtadsgyltrklvdvtheivvreadcgttnyisvplfqpdevtrslrlrkradi
eaglygrvlarevevlgvrleegrylsmddvhllikaaeageiqevpvrspltcqtrygv
cqkcygydlsmarpvsigeavgivaaqsigepgtqltmrtfhtggvagaaditqglprvi
elfearrpkakaviseidgvvrieeteeklsvfvesegfskeyklpkearllvkdgdyve
agqpltrgaidphqlleakgpeaverylveeiqkvyraqgvklhdkhieivvrqmmkyve
vtdpgdsrllegqvlekwdvealnerliaegktpvawkpllmgvtksalstkswlsaasf
qntthvlteaaiagkkdeliglkenvilgrlipagtgsdfvrftqvvdqktlkaieeark
eaveakerpaarrgvkreqpgkqa

    Sequence, based on observed residues (ATOM records): (download) 
    >6cuuD (D:)
kevrkvrialaspekirswsygevekpetinyrtlkperdglfderifgpikdyecacgk
ykrqrfegkvcercgvevtksivrryrmghielatpaahiwfvkdvpskigtlldlsate
leqvlyfskyivldpkgailngvpvekrqlltdeeyrelrygkqetyplppgvdalvkdg
eevvkgqelapgvvsrldgvalyrfprrvrveyvkkeraglrlplaawvekeaykpgeil
aelpepylfraeeegvvelkeleegaflvlrredepvatyflpvgmtplvvhgeivekgq
plaeakgllrmprqvraaqveaeeegetvyltlflewtepkdyrvqphmnvvvpegarve
agdkivaaidpeeeviaeaegvvhlhepasilvvkarvypfeddvevstgdrvapgdvla
dggkvksdvygrvevdlvrnvvrvvesydidarmgaeaiqqllkeldlealekelleemk
hpsrarrakarkrlevvrafldsgnrpewmileavpvlppdlrpmvqvdggrfatsdlnd
lyrrlinrnnrlkkllaqgapeiiirnekrmlqeavdalldngrrgapvtnpgsdrplrs
ltdilsgkqgrfrqnllgkrvdysgrsvivvgpqlklhqcglpkrmalelfkpfllkkme
ekgiapnvkaarrmlerqrdikdevwdaleevihgkvvllnraptlhrlgiqafqpvlve
gqsiqlhplvceafnadfdgdqmavhvplssfaqaeariqmlsahnllspasgeplakps
rdiilglyyitqvrkekkgaglefatpeealaahergevalnapikvagretsvgrlkyv
fanpdeallavahgivdlqdvvtvrymgkrletspgrilfarivaeavedekvaweliql
dvpqeknslkdlvyqaflrlgmektarlldalkyygftfsttsgitigiddavipeekkq
yleeadrkllqieqayemgfltdrerydqilqlwtettekvtqavfknfeenypfnplyv
maqsgargnpqqirqlcglrglmqkpsgetfevpvrssfregltvleyfisshgarkgga
dtalrtadsgyltrklvdvtheivvreadcgttnyisvplfqpdevtrslrlrkradiea
glygrvlarevevlgvrleegrylsmddvhllikaaeageiqevpvrspltcqtrygvcq
kcygydlsmarpvsigeavgivaaqsigepgtqlttqglprvielfearrpkakavisei
dgvvrieeteeklsvfvesegfskeyklpkearllvkdgdyveagqpltrgaidphqlle
akgpeaverylveeiqkvyraqgvklhdkhieivvrqmmkyvevtdpgdsrllegqvlek
wdvealnerliaegktpvawkpllmgvtksalstkswlsaasfqntthvlteaaiagkkd
eliglkenvilgrlipagtgsdfvrftqvvdqktlkaieearkea

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6cuuE (E:)
maepgidklfgmvdskyrltvvvakraqqllrhgfkntvlepeerpkmqtleglfddpna
vtwamkelltgrlvfgenlvpedrlqkemerlypveree

    Sequence, based on observed residues (ATOM records): (download) 
    >6cuuE (E:)
aepgidklfgmvdskyrltvvvakraqqllrhgfkntvlepeerpkmqtleglfddpnav
twamkelltgrlvfgenlvpedrlqkemerlypv

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6cuuF (F:)
mkkskrknaqaqeaqetevlvqeeaeelpefpegepdpdledpdlaleddlldlpeegeg
ldleeeeedlpipkistsdpvrqylheigqvplltleeevelarkveegmeaikklseit
gldpdlirevvrakilgsarvrhipglketldpktveeidqklkslpkehkrylhiareg
eaarqhlieanlrlvvsiakkytgrglsfldliqegnqgliravekfeykrrfkfstyat
wwirqainraiadqartiripvhmvetinklsrtarqlqqelgreptyeeiaeamgpgwd
akrveetlkiaqepvsletpigdekdsfygdfipdehlpspvdaatqsllseelekalsk
lsereamvlklrkglidgrehtleevgaffgvtrerirqienkalrklkyhesrtrklrd
fld

    Sequence, based on observed residues (ATOM records): (download) 
    >6cuuF (F:)
sdpvrqylheigqvplltleeevelarkveegmeaikklseitgldpdlirevvrakilg
sarvrhipglketldpktveeidqklkslpkehkrylhiaregeaarqhlieanlrlvvs
iakkytgrglsfldliqegnqgliravekfeykrrfkfstyatwwirqainraiadqart
iripvhmvetinklsrtarqlqqelgreptyeeiaeamgpgwdakrveetlkiaqepvsl
etpigdekdsfygdfipdehlpspvdaatqsllseelekalsklsereamvlklrkglid
grehtleevgaffgvtrerirqienkalrklkyhesrtrklrdfld

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.