SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.2.1.2: Tyrosine-dependent oxidoreductases

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2090553Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 protein domains)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

Protein Domains:

  1. 2090554(3R)-hydroxyacyl-CoA dehydrogenase domain of estradiol 17 beta-Dehydrogenase 4 [82294] (1 species)
    peroxisomal multifunctional enzyme type 2
    segment swapping involving a C-terminal extension to the family fold
  2. 2090560(s)-1-phenylethanol dehydrogenase [141902] (1 species)
  3. 20905651,3,6,8-tetrahydroxynaphthalene reductase [63929] (1 species)
  4. 20905681,3,8-trihydroxynaphtalene reductase (THNR, naphtol reductase) [51798] (1 species)
  5. 209058011-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
    1. 2090581Species Guinea pig (Cavia porcellus) [TaxId:10141] [117425] (4 PDB entries)
      Uniprot Q6QLL4 23-296
    2. 2090596Species Human (Homo sapiens) [TaxId:9606] [117424] (29 PDB entries)
      Uniprot P28845
    3. 2090702Species Mouse (Mus musculus) [TaxId:10090] [141879] (5 PDB entries)
      Uniprot P50172 24-298
  6. 209072115-hydroxyprostaglandin dehydrogenase, PGDH [141888] (1 species)
  7. 209072417-beta-hydroxysteroid dehydrogenase type XI [117426] (1 species)
  8. 20907282,4-dienoyl-CoA reductase, mitochondrial (DECR) [117421] (1 species)
  9. 20907423-alpha,20-beta-hydroxysteroid dehydrogenase [51776] (1 species)
  10. 20907523-alpha-hydroxysteroid dehydrogenase [51778] (1 species)
  11. 20907583beta/17beta hydroxysteroid dehydrogenase [82290] (1 species)
  12. 20907647-alpha-hydroxysteroid dehydrogenase [51774] (1 species)
  13. 2090772ADP-L-glycero-D-mannoheptose 6-epimerase [51761] (1 species)
  14. 2090784Aldehyde reductase II [117413] (1 species)
  15. 2090792Bacterial sepiapterin reductase [141892] (1 species)
  16. 2090798beta-keto acyl carrier protein reductase [51788] (8 species)
    1. 2090799Species Escherichia coli [TaxId:562] [51790] (3 PDB entries)
    2. 2090814Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [141877] (1 PDB entry)
      Uniprot Q86RB1 54-304
    3. 2090816Species Mycobacterium tuberculosis [TaxId:1773] [141875] (2 PDB entries)
      Uniprot P0A5Y4 9-245! Uniprot P0A5Y4 9-247
    4. 2090819Species Oil seed rape (Brassica napus) [TaxId:3708] [51789] (2 PDB entries)
    5. 2090827Species Streptomyces coelicolor [TaxId:1902] [117408] (8 PDB entries)
      Uniprot P16544 #SP
    6. 2090844Species Thermotoga maritima [TaxId:2336] [102150] (1 PDB entry)
      TM1169
    7. 2090849Species Thermus thermophilus [TaxId:274] [117407] (1 PDB entry)
      Uniprot Q5SK98
    8. 2090858Species Thermus thermophilus, TTHB020 [TaxId:274] [141876] (1 PDB entry)
      Uniprot Q53WH2 2-242
  17. 2090861Biliverdin IX beta reductase [63931] (1 species)
    Histidine in the active site instead of the Tyr-Lys dyad
  18. 2090868Carbonyl reductase [51765] (2 species)
    1. 2090869Species Human (Homo sapiens) [TaxId:9606] [102144] (1 PDB entry)
      dicarbonyl/L-xylulose reductase
    2. 2090872Species Mouse (Mus musculus) [TaxId:10090] [51766] (1 PDB entry)
  19. 2090877Carbonyl reductase sniffer [110413] (2 species)
    1. 2090878Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [110414] (1 PDB entry)
      Uniprot Q9W3H4 # cg10964-pa
    2. 2090880Species Nematode (Caenorhabditis elegans) [TaxId:6239] [186880] (1 PDB entry)
  20. 2090886Carbonyl reductase/20beta-hydroxysteroid dehydrogenase [63935] (2 species)
    1. 2090887Species Human (Homo sapiens) [TaxId:9606] [141878] (6 PDB entries)
      Uniprot P16152 2-276
    2. 2090897Species Pig (Sus scrofa) [TaxId:9823] [63936] (2 PDB entries)
  21. 2090900CDP-glucose-4,6-dehydratase [102136] (3 species)
    1. 2090901Species Salmonella enterica [TaxId:220341] [190019] (1 PDB entry)
    2. 2090903Species Salmonella typhimurium [TaxId:90371] [141873] (1 PDB entry)
      Uniprot P26397 2-356
    3. 2090905Species Yersinia pseudotuberculosis [TaxId:633] [102137] (1 PDB entry)
  22. 2090910CDP-tyvelose-2-epimerase [102138] (1 species)
  23. 2090916Cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase [51780] (1 species)
  24. 2090919D(-)-3-hydroxybutyrate dehydrogenase [141886] (1 species)
  25. 2090922Dehydrogenase/reductase SDR family member 6, DHRS6 [141894] (1 species)
    Oxidoreductase UCPA
  26. 2090925Dihydropteridin reductase (pteridine reductase) [51769] (7 species)
    1. 2090926Species Human (Homo sapiens) [TaxId:9606] [51771] (1 PDB entry)
    2. 2090928Species Leishmania major [TaxId:5664] [63926] (11 PDB entries)
      Uniprot Q01782
    3. 2090982Species Leishmania tarentolae [TaxId:5689] [102145] (1 PDB entry)
    4. 2090987Species Nematode (Caenorhabditis elegans) [TaxId:6239] [89520] (1 PDB entry)
    5. 2090990Species Norway rat (Rattus norvegicus) [TaxId:10116] [51770] (2 PDB entries)
    6. 2090996Species Trypanosoma brucei [TaxId:5702] [226783] (13 PDB entries)
    7. 2091033Species Trypanosoma cruzi [TaxId:5693] [102146] (2 PDB entries)
  27. 2091042Drosophila alcohol dehydrogenase [51782] (2 species)
    1. 2091043Species Fly (Drosophila lebanonensis) [TaxId:7225] [51783] (8 PDB entries)
    2. 2091063Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [102147] (1 PDB entry)
  28. 2091066DTDP-4-dehydrorhamnose reductase RfbD [110409] (1 species)
  29. 2091071dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) [75102] (2 species)
    1. 2091072Species Salmonella enterica [311157] (1 PDB entry)
    2. 2091074Species Salmonella typhimurium [TaxId:90371] [75103] (4 PDB entries)
  30. 2091079dTDP-glucose 4,6-dehydratase (RmlB) [51755] (4 species)
    1. 2091080Species Escherichia coli [TaxId:562] [51756] (1 PDB entry)
    2. 2091083Species Salmonella enterica [TaxId:28901] [63925] (1 PDB entry)
    3. 2091088Species Streptococcus suis, serotype 2 [TaxId:1307] [69406] (6 PDB entries)
    4. 2091101Species Streptomyces venezuelae [TaxId:54571] [102133] (2 PDB entries)
  31. 2091104Enoyl-ACP reductase [51791] (11 species)
    1. 2091105Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [188487] (1 PDB entry)
    2. 2091110Species Bacillus cereus [TaxId:226900] [192761] (2 PDB entries)
    3. 2091115Species Bacillus subtilis [TaxId:1423] [189591] (2 PDB entries)
    4. 2091121Species Escherichia coli [TaxId:562] [51794] (13 PDB entries)
    5. 2091158Species Helicobacter pylori [TaxId:210] [102151] (4 PDB entries)
    6. 2091172Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [82296] (23 PDB entries)
      Uniprot Q9BJJ9 96-424 # fragment
    7. 2091220Species Mycobacterium leprae [TaxId:1769] [187924] (1 PDB entry)
    8. 2091223Species Mycobacterium tuberculosis, TB, gene InhA [TaxId:1773] [51793] (70 PDB entries)
    9. 2091367Species Oil seed rape (Brassica napus) [TaxId:3708] [51792] (4 PDB entries)
    10. 2091373Species Staphylococcus aureus [TaxId:1280] [189086] (3 PDB entries)
    11. 2091381Species Thermus thermophilus [TaxId:274] [117409] (1 PDB entry)
      Uniprot Q5SLI9
  32. 2091386Erythromycin synthase, eryAI, 1st ketoreductase module [141909] (1 species)
    tandem repeat of two SDR-like modules resembling a dimer commonly founf in the family; only the second module retains the coenzyme-binding site
  33. 2091392GDP-4-keto-6-deoxy-d-mannose epimerase/reductase (GDP-fucose synthetase) [51757] (1 species)
  34. 2091402GDP-mannose 4,6-dehydratase [51759] (4 species)
    1. 2091403Species Escherichia coli [TaxId:562] [51760] (1 PDB entry)
    2. 2091405Species Human (Homo sapiens) [TaxId:9606] [102135] (3 PDB entries)
    3. 2091410Species Pseudomonas aeruginosa [TaxId:287] [102134] (1 PDB entry)
    4. 2091415Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [82289] (2 PDB entries)
  35. 2091422GDP-mannose-3', 5'-epimerase [141890] (1 species)
  36. 2091428Gluconate 5-dehydrogenase [110411] (1 species)
  37. 2091432Glucose dehydrogenase [51784] (1 species)
  38. 2091450Glucose dehydrogenase (5l265) [102155] (1 species)
  39. 2091453Halohydrin dehalogenase HheC [102153] (1 species)
    haloalcohol dehalogenase: evolved a new activity; lost the NAD-binding site
  40. 2091485Human estrogenic 17beta-hydroxysteroid dehydrogenase [51772] (1 species)
  41. 2091517Hypothetical protein At5g02240 (T7H20_290) [117417] (1 species)
  42. 2091527Hypothetical protein F25D1.5 [110415] (1 species)
  43. 2091531Hypothetical protein PA4017 [141911] (1 species)
    unknown function; the active site region is blocked by a loop; strong sequence similarity to mammalian TAT-interacting protein TIP30
  44. 2091535Hypothetical protein R05D8.7 [117415] (1 species)
  45. 2091541Hypothetical protein TTHA0369 [141896] (1 species)
    TT0321
  46. 2091544Levodione reductase [89523] (1 species)
  47. 2091554Mannitol dehydrogenase [63927] (1 species)
  48. 2091568meso-2,3-butanediol dehydrogenase [51786] (1 species)
  49. 2091578Negative transcriptional regulator NmrA [69407] (1 species)
    has an UDP-galactose 4-epimerase-like structure but evolved a different function
  50. 2091587Peroxisomal multifunctional enzyme type 2 [141900] (1 species)
    17-beta-hydroxysteroid dehydrogenase 4
  51. 2091595Peroxisomal trans 2-enoyl CoA reductase [141884] (1 species)
  52. 2091601Phenylcoumaran benzylic ether reductase [102140] (1 species)
  53. 2091605Pinoresinol-lariciresinol reductase [102142] (1 species)
  54. 2091611Polymyxin resistance protein ArnA (PrmI) [117419] (1 species)
    evolved new activities: UDP-glucuronic acid decarboxylase, UDP-4-amino-4-deoxy-L-arabinose formyltransferase
  55. 2091629Putative carbonyl reductase sniffer [141913] (1 species)
  56. 2091632Putative dehydrogenase ARPG836 (MGC4172) [117411] (1 species)
  57. 2091638Putative oxidoreductase Rv2002 [82292] (1 species)
  58. 2091650R-specific alcohol dehydrogenase [89521] (1 species)
  59. 2091654Retinal dehydrogenase/reductase 3 [141907] (1 species)
  60. 2091657Rhizome secoisolariciresinol dehydrogenase [141898] (1 species)
  61. 2091660Sepiapterin reductase [51767] (2 species)
    1. 2091661Species Human (Homo sapiens) [TaxId:9606] [141874] (6 PDB entries)
      Uniprot P35270 5-261
    2. 2091688Species Mouse (Mus musculus) [TaxId:10090] [51768] (3 PDB entries)
  62. 2091692Sorbitol dehydrogenase [102148] (1 species)
  63. 2091696Sulfolipid biosynthesis protein SQD1 [51763] (1 species)
  64. 2091702TAT-interacting protein TIP30 [141904] (2 species)
    1. 2091703Species Human (Homo sapiens) [TaxId:9606] [141905] (1 PDB entry)
      Uniprot Q9BUP3 5-236
    2. 2091705Species Mouse (Mus musculus) [TaxId:10090] [141906] (1 PDB entry)
      Uniprot Q9Z2G9 7-236
  65. 2091707Tropinone reductase [51795] (3 species)
    1. 2091708Species Jimsonweed (Datura stramonium), I [TaxId:4076] [51796] (1 PDB entry)
    2. 2091711Species Jimsonweed (Datura stramonium), II [TaxId:4076] [51797] (4 PDB entries)
    3. 2091719Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [117410] (1 PDB entry)
      Uniprot Q9ASX2
  66. 2091721Type II 3-hydroxyacyl-CoA dehydrogenase [63933] (3 species)
    1. 2091722Species Human (Homo sapiens) [TaxId:9606] [102152] (2 PDB entries)
      Uniprot Q99714
    2. 2091728Species Norway rat (Rattus norvegicus) [TaxId:10116] [63934] (3 PDB entries)
    3. 2091741Species Thermus thermophilus [TaxId:274] [89525] (1 PDB entry)
  67. 2091744UDP-glucuronate decarboxylase 1 [141880] (1 species)
  68. 2091747UDP-N-acetylglucosamine 4-epimerase WbpP [110407] (1 species)
  69. 2091751Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase) [51752] (4 species)
    1. 2091752Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [141872] (1 PDB entry)
      Uniprot P04397 11-357
      N-terminal domain of bifunctional Gal10 protein
    2. 2091754Species Escherichia coli [TaxId:562] [51753] (17 PDB entries)
    3. 2091773Species Human (Homo sapiens) [TaxId:9606] [51754] (7 PDB entries)
    4. 2091787Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [89519] (1 PDB entry)
  70. 2091792Xylitol dehydrogenase [141882] (1 species)
  71. 2091795automated matches [190085] (50 species)
    not a true protein
    1. 2091796Species Acinetobacter baumannii [TaxId:470] [272807] (1 PDB entry)
    2. 2091798Species Alcaligenes faecalis [TaxId:511] [188427] (11 PDB entries)
    3. 2091826Species Alfalfa (Medicago sativa) [TaxId:3879] [187740] (1 PDB entry)
    4. 2091829Species Aquifex aeolicus [TaxId:224324] [188271] (2 PDB entries)
    5. 2091838Species Bacillus anthracis [TaxId:198094] [188031] (1 PDB entry)
    6. 2091847Species Bacillus megaterium [TaxId:1404] [195340] (5 PDB entries)
    7. 2091860Species Burkholderia pseudomallei [TaxId:272560] [279838] (10 PDB entries)
    8. 2091862Species Burkholderia pseudomallei [TaxId:320372] [188614] (3 PDB entries)
    9. 2091870Species Burkholderia pseudomallei [TaxId:884204] [238338] (1 PDB entry)
    10. 2091872Species Chlamydia trachomatis [TaxId:1340853] [257638] (1 PDB entry)
    11. 2091881Species Comamonas testosteroni [TaxId:285] [189779] (3 PDB entries)
    12. 2091888Species Eimeria tenella [TaxId:413949] [187997] (1 PDB entry)
    13. 2091891Species Emericella nidulans [TaxId:162425] [187249] (3 PDB entries)
    14. 2091916Species Escherichia coli K-12 [TaxId:83333] [189924] (3 PDB entries)
    15. 2091923Species Escherichia coli [TaxId:469008] [256724] (3 PDB entries)
    16. 2091930Species Escherichia coli [TaxId:562] [255679] (2 PDB entries)
    17. 2091961Species Francisella tularensis [TaxId:177416] [189289] (1 PDB entry)
    18. 2091966Species Francisella tularensis [TaxId:263] [188795] (1 PDB entry)
    19. 2091971Species Human (Homo sapiens) [TaxId:9606] [186828] (18 PDB entries)
    20. 2092010Species Klebsiella pneumoniae [TaxId:573] [276380] (1 PDB entry)
    21. 2092013Species Lactobacillus brevis [TaxId:1580] [186912] (6 PDB entries)
    22. 2092027Species Leishmania donovani [TaxId:5661] [189607] (1 PDB entry)
    23. 2092030Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [186807] (1 PDB entry)
    24. 2092032Species Mycobacterium tuberculosis [TaxId:83332] [229356] (1 PDB entry)
    25. 2092039Species Neisseria meningitidis [TaxId:272831] [228105] (3 PDB entries)
    26. 2092046Species Pandoraea pnomenusa [TaxId:93220] [189780] (3 PDB entries)
    27. 2092053Species Plasmodium berghei [TaxId:5821] [189246] (1 PDB entry)
    28. 2092058Species Plasmodium falciparum [TaxId:36329] [228763] (2 PDB entries)
    29. 2092063Species Plesiomonas shigelloides [TaxId:703] [189972] (9 PDB entries)
    30. 2092098Species Pseudomonas aeruginosa, PA01 [TaxId:208964] [261223] (2 PDB entries)
    31. 2092119Species Pseudomonas fragi [TaxId:296] [188080] (6 PDB entries)
    32. 2092138Species Pseudomonas putida [TaxId:303] [188252] (3 PDB entries)
    33. 2092155Species Rhizobium radiobacter [TaxId:358] [197100] (3 PDB entries)
    34. 2092162Species Sinorhizobium meliloti [TaxId:266834] [195628] (1 PDB entry)
    35. 2092167Species Staphylococcus aureus [TaxId:282458] [193773] (1 PDB entry)
    36. 2092169Species Streptomyces coelicolor [TaxId:1902] [189970] (5 PDB entries)
    37. 2092180Species Streptomyces griseoruber [TaxId:1943] [196180] (1 PDB entry)
    38. 2092183Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [187183] (5 PDB entries)
    39. 2092189Species Thermus thermophilus HB8 [TaxId:300852] [187188] (4 PDB entries)
    40. 2092210Species Thermus thermophilus [TaxId:274] [187600] (1 PDB entry)
    41. 2092214Species Toxoplasma gondii [TaxId:383379] [187942] (3 PDB entries)
    42. 2092225Species Toxoplasma gondii [TaxId:5811] [261808] (1 PDB entry)
    43. 2092228Species Trypanosoma brucei [TaxId:5702] [187520] (4 PDB entries)
    44. 2092245Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [187036] (1 PDB entry)
    45. 2092250Species Vibrio cholerae [TaxId:243277] [189479] (8 PDB entries)
    46. 2092265Species Vibrio cholerae [TaxId:593588] [189768] (3 PDB entries)
    47. 2092276Species Yersinia pestis [TaxId:632] [279426] (2 PDB entries)
    48. 2274813Species Narcissus pseudonarcissus [TaxId:39639] [318114] (2 PDB entries)
    49. 2283377Species Escherichia coli [TaxId:83333] [326678] (1 PDB entry)
    50. 2286710Species Burkholderia pseudomallei [TaxId:28450] [330011] (1 PDB entry)

More info for Family c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Family c.2.1.2: Tyrosine-dependent oxidoreductases: