SCOPe 2.08: Domain d6wepa2: 6wep A:193-519

Lineage for d6wepa2 (6wep A:193-519)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841] (2 species)

7. Species Cryptosporidium hominis [TaxId:237895] [100887] (16 PDB entries)

8. Domain d6wepa2: 6wep A:193-519 [388020]
   Other proteins in same PDB: d6wepa1, d6wepb1
   automated match to d1qzfa2
   complexed with mtx, ndp

Details for d6wepa2

PDB Entry: 6wep, 2.79 Å

PDB Description: crystal structure of ts-dhfr from cryptosporidium hominis with apo-ts site

PDB Compounds: (A:) Bifunctional dihydrofolate reductase-thymidylate synthase

SCOPe Domain Sequences for d6wepa2:

Sequence; same for both SEQRES and ATOM records:

>d6wepa2 d.117.1.1 (A:193-519) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain {Cryptosporidium hominis [TaxId: 237895]}
lksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyldllsrvlenga
yrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgdtngnhliekk
vyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytgvgvdqlakli
etlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyqrscdlglgsp
fniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtprpfpqlkfkrk
veniedfkwedieligyypyptikmdm

Timeline for d6wepa2:

• d6wepa2 first appeared in SCOPe 2.07