SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2190102Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
    contains large mixed beta-sheet
  4. 2190103Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families) (S)
    automatically mapped to Pfam PF00303
  5. 2190104Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 protein domains)

Protein Domains:

  1. 2190105Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841] (2 species)
    1. 2190106Species Cryptosporidium hominis [TaxId:237895] [100887] (4 PDB entries)
    2. 2190127Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88964] (3 PDB entries)
  2. 2190134dCMP hydroxymethylase [55843] (1 species)
  3. 2190142Thymidylate synthase [55833] (7 species)
    1. 2190143Species Bacillus subtilis [TaxId:1423] [55836] (5 PDB entries)
    2. 2190155Species Bacteriophage T4 [TaxId:10665] [55837] (1 PDB entry)
    3. 2190157Species Escherichia coli [TaxId:562] [55834] (67 PDB entries)
    4. 2190276Species Fungus (Pneumocystis carinii) [TaxId:4754] [55838] (2 PDB entries)
    5. 2190283Species Human (Homo sapiens) [TaxId:9606] [55840] (26 PDB entries)
    6. 2190340Species Lactobacillus casei [TaxId:1582] [55835] (51 PDB entries)
    7. 2190392Species Norway rat (Rattus norvegicus) [TaxId:10116] [55839] (2 PDB entries)
  4. 2190399automated matches [190469] (14 species)
    not a true protein
    1. 2190400Species Corynebacterium glutamicum [TaxId:196627] [227854] (2 PDB entries)
    2. 2190407Species Cryptosporidium hominis [TaxId:237895] [232024] (3 PDB entries)
    3. 2190420Species Encephalitozoon cuniculi [TaxId:284813] [189107] (1 PDB entry)
    4. 2190422Species Enterococcus faecalis [TaxId:1351] [194752] (3 PDB entries)
    5. 2190431Species Fungus (Filobasidiella neoformans) [TaxId:5207] [187389] (1 PDB entry)
    6. 2190448Species Human (Homo sapiens) [TaxId:9606] [189245] (8 PDB entries)
    7. 2190467Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [188759] (2 PDB entries)
    8. 2190472Species Mouse (Mus musculus) [TaxId:10090] [225826] (7 PDB entries)
    9. 2190494Species Mycobacterium tuberculosis [TaxId:1773] [189990] (2 PDB entries)
    10. 2190503Species Mycobacterium tuberculosis [TaxId:83332] [224938] (3 PDB entries)
    11. 2190518Species Staphylococcus aureus [TaxId:158878] [195805] (1 PDB entry)
    12. 2190521Species Trichinella spiralis [TaxId:6334] [226731] (1 PDB entry)
    13. 2190526Species Varicella-zoster virus (strain oka vaccine) [TaxId:341980] [311478] (3 PDB entries)
    14. 2285170Species Human herpesvirus 8 [TaxId:37296] [328471] (3 PDB entries)

More info for Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase

Timeline for Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase: