SCOPe 2.08: Domain d6thpb_: 6thp B:

Lineage for d6thpb_ (6thp B:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ('zincins'), catalytic domain [55486] (18 families)

5. Family d.92.1.4: Neutral endopeptidase (neprilysin) [55502] (2 proteins)

6. Protein Neutral endopeptidase (neprilysin) [55503] (1 species)
   contains thermolysin-like catalytic domain (residues 419-749)
   the N-terminal half of the structure is multihelical

7. Species Human (Homo sapiens) [TaxId:9606] [55504] (12 PDB entries)
   Uniprot P08473 54-749

8. Domain d6thpb_: 6thp B: [380525]
   automated match to d1dmta_
   complexed with n9q, nag, zn

Details for d6thpb_

PDB Entry: 6thp, 2.54 Å

PDB Description: neprilysin in complex with the inhibitor (r)-4-(1-carboxy-3-(3'- chlorobiphenyl-4-yl)propan-2-ylamino)-4-oxobutanoic acid

PDB Compounds: (B:) Neprilysin

SCOPe Domain Sequences for d6thpb_:

Sequence; same for both SEQRES and ATOM records:

>d6thpb_ d.92.1.4 (B:) Neutral endopeptidase (neprilysin) {Human (Homo sapiens) [TaxId: 9606]}
gickssdciksaarliqnmdattepctdffkyacggwlkrnvipetssrygnfdilrdel
evvlkdvlqepktedivavqkakalyrscinesaidsrggepllkllpdiygwpvatenw
eqkygaswtaekaiaqlnskygkkvlinlfvgtddknsvnhvihidqprlglpsrdyyec
tgiykeactayvdfmisvarlirqeerlpidenqlalemnkvmelekeianatakpedrn
dpmllynkmtlaqiqnnfsleingkpfswlnftneimstvnisitneedvvvyapeyltk
lkpiltkysardlqnlmswrfimdlvsslsrtykesrnafrkalygttsetatwrrcany
vngnmenavgrlyveaafageskhvvedliaqirevfiqtlddltwmdaetkkraeekal
aikerigypddivsndnklnneylelnykedeyfeniiqnlkfsqskqlkklrekvdkde
wisgaavvnafyssgrnqivfpagilqppffsaqqsnslnyggigmvigheithgfddng
rnfnkdgdlvdwwtqqsasnfkeqsqcmvyqygnfswdlaggqhlngintlgeniadngg
lgqayrayqnyikkngeekllpgldlnhkqlfflnfaqvwcgtyrpeyavnsiktdvhsp
gnfriigtlqnsaefseafhcrknsymnpekkcrvw

Timeline for d6thpb_:

• d6thpb_ first appeared in SCOPe 2.07