SCOPe 2.08: Species: Human (Homo sapiens) [TaxId: 9606]

Root: SCOPe 2.08
Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
Fold d.92: Zincin-like [55485] (2 superfamilies)
contains mixed beta sheet with connection over free side of the sheet
Superfamily d.92.1: Metalloproteases ('zincins'), catalytic domain [55486] (18 families)
Family d.92.1.4: Neutral endopeptidase (neprilysin) [55502] (2 proteins)
Protein Neutral endopeptidase (neprilysin) [55503] (1 species)
contains thermolysin-like catalytic domain (residues 419-749)
the N-terminal half of the structure is multihelical
Species Human (Homo sapiens) [TaxId:9606] [55504] (12 PDB entries)
Uniprot P08473 54-749

Domain(s) for 1dmt:
- Domain d1dmta_: 1dmt A: [40296]
  complexed with gol, nag, rdf, zn
Domain(s) for 1r1h:
- Domain d1r1ha_: 1r1h A: [104756]
  complexed with bir, nag, zn
Domain(s) for 1r1i:
- Domain d1r1ia_: 1r1i A: [104757]
  complexed with nag, ti1, zn
Domain(s) for 1r1j:
- Domain d1r1ja_: 1r1j A: [104758]
  complexed with nag, oir, zn
Domain(s) for 1y8j:
- Domain d1y8ja_: 1y8j A: [122752]
  automated match to d1dmta_
  complexed with act, nag, sts, zn
Domain(s) for 2qpj:
- Domain d2qpja_: 2qpj A: [151205]
  automated match to d1dmta_
  complexed with i20, nag, zn
Domain(s) for 5jmy:
1. Domain d5jmya_: 5jmy A: [318588]
  automated match to d4ctha_
  complexed with 6ld, nag, zn
2. Domain d5jmyb_: 5jmy B: [318623]
  automated match to d4ctha_
  complexed with 6ld, nag, zn
Domain(s) for 6gid:
- Domain d6gida_: 6gid A: [353991]
  automated match to d1dmta_
  complexed with edo, gol, nag, no3, peg, po4, zn
Domain(s) for 6suk:
- Domain d6suka_: 6suk A: [385565]
  automated match to d4ctha_
  complexed with edo, ft8, nag, peg, zn
Domain(s) for 6svy:
- Domain d6svya_: 6svy A: [385547]
  automated match to d4ctha_
  complexed with d0w, nag, zn
Domain(s) for 6thp:
1. Domain d6thpa_: 6thp A: [380529]
  automated match to d1dmta_
  complexed with n9q, nag, zn
2. Domain d6thpb_: 6thp B: [380525]
  automated match to d1dmta_
  complexed with n9q, nag, zn
Domain(s) for 6xvp:
- Domain d6xvpa_: 6xvp A: [385663]
  automated match to d4ctha_
  complexed with d0z, edo, nag, zn

Timeline for Species Human (Homo sapiens) [TaxId:9606] from d.92.1.4 Neutral endopeptidase (neprilysin):

Species Human (Homo sapiens) [TaxId:9606] from d.92.1.4 Neutral endopeptidase (neprilysin) first appeared (with stable ids) in SCOP 1.55
Species Human (Homo sapiens) [TaxId:9606] from d.92.1.4 Neutral endopeptidase (neprilysin) appears in SCOPe 2.07