Lineage for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2528985Fold d.92: Zincin-like [55485] (2 superfamilies)
    contains mixed beta sheet with connection over free side of the sheet
  4. 2528986Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families) (S)

Families:

  1. 2528987d.92.1.1: Zinc protease [55487] (2 proteins)
    single domain
    automatically mapped to Pfam PF02031
  2. 2529000d.92.1.2: Thermolysin-like [55490] (5 proteins)
    includes alpha-helical C-terminal domain characteristic for the family
  3. 2529206d.92.1.3: Leishmanolysin [55499] (1 protein)
    automatically mapped to Pfam PF01457
  4. 2529210d.92.1.4: Neutral endopeptidase (neprilysin) [55502] (2 proteins)
  5. 2529230d.92.1.5: Neurolysin-like [55505] (5 proteins)
    combines M2, M3 and M32 families of metalloproteases
    the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain
  6. 2529316d.92.1.6: Serralysin-like metalloprotease, catalytic (N-terminal) domain [55508] (2 proteins)
    characteristic HEXXHXXGXXH motif and Met located near C-terminus
  7. 2529349d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (2 proteins)
  8. 2529452d.92.1.8: Astacin [55516] (2 proteins)
    automatically mapped to Pfam PF01400
  9. 2529463d.92.1.9: Reprolysin-like [55519] (3 proteins)
    Pfam PF01421
  10. 2529506d.92.1.10: TNF-alpha converting enzyme, TACE, catalytic domain [55525] (2 proteins)
    automatically mapped to Pfam PF13574
    automatically mapped to Pfam PF13583
  11. 2529558d.92.1.11: Matrix metalloproteases, catalytic domain [55528] (14 proteins)
  12. 2530001d.92.1.12: Fungal zinc peptidase [64335] (1 protein)
    single domain with insertions in the common fold
  13. 2530011d.92.1.13: Zn aminopeptidase catalytic domain [64338] (5 proteins)
    adopts thermolysin-like fold
  14. 2530100d.92.1.14: Anthrax toxin lethal factor, N- and C-terminal domains [69775] (2 proteins)
    automatically mapped to Pfam PF07737
  15. 2530150d.92.1.15: Predicted metal-dependent hydrolase [103132] (4 proteins)
    Pfam PF02130; UPF0054; COG0319; MMP-like fold with a different sequence motif in the putative active site
  16. 2530166d.92.1.16: Caur0242-like [160552] (1 protein)
    Pfam PF10103; DUF2342; there is a characteristic HExxH motif but no metal ion bound to it in the first structure.
  17. 2530170d.92.1.17: TTHA0227-like [160555] (2 proteins)
    Pfam PFPF06262; DUF1025; minimal zincin fold that retains 3-stranded mixed beta-sheet and contains HExxH motif in the C-terminal helix; no metal ion bound to this motif is observed in the first determined structures
    Pfam PF06262; DUF1025; minimal zincin fold that retains 3-stranded mixed beta-sheet and contains HExxH motif in the C-terminal helix; no metal ion bound to this motif is observed in the first determined structures
  18. 2530179d.92.1.0: automated matches [191495] (1 protein)
    not a true family

More info for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain

Timeline for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain: