SCOPe 2.08: Domain d6pfed2: 6pfe D:181-521

Lineage for d6pfed2 (6pfe D:181-521)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841] (2 species)

7. Species Cryptosporidium hominis [TaxId:237895] [100887] (16 PDB entries)

8. Domain d6pfed2: 6pfe D:181-521 [375083]
   Other proteins in same PDB: d6pfea1, d6pfeb1, d6pfec1, d6pfed1, d6pfee1
   automated match to d1qzfa2
   complexed with mtx, ndp, oea, ufp

Details for d6pfed2

PDB Entry: 6pfe, 2.81 Å

PDB Description: crystal structure of ts-dhfr from cryptosporidium hominis in complex with nadph, fdump and 2-(4-((2-amino-4-oxo-4,7-dihydro-3h-pyrrolo[2, 3-d]pyrimidin-5-yl)methyl)benzamido)-4-methoxybenzoic acid.

PDB Compounds: (D:) Bifunctional dihydrofolate reductase-thymidylate synthase

SCOPe Domain Sequences for d6pfed2:

Sequence, based on SEQRES records:

>d6pfed2 d.117.1.1 (D:181-521) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain {Cryptosporidium hominis [TaxId: 237895]}
ktlqncdpargqlksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqy
ldllsrvlengayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfik
gdtngnhliekkvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddy
tgvgvdqlaklietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnl
yqrscdlglgspfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrt
prpfpqlkfkrkveniedfkwedieligyypyptikmdmav

Sequence, based on observed residues (ATOM records):

>d6pfed2 d.117.1.1 (D:181-521) Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain {Cryptosporidium hominis [TaxId: 237895]}
klksiddtvdllgeifgirkmgnrhkfpkeeiyntpsirfgrehyefqyldllsrvleng
ayrenrtgistysifgqmmrfdmresfpllttkkvairsifeeliwfikgdtngnhliek
kvyiwsgngskeyleriglghreendlgpiygfqwrhyngeyktmhddytgvgvdqlakl
ietlknnpkdrrhiltawnpsalsqmalppchvlsqyyvtndnclscnlyqrscdlglgs
pfniasyailtmmlaqvcgyepgelaifigdahiyenhltqlkeqlsrtprpfpqlkfkr
kveniedfkwedieligyypyptikmdmav

Timeline for d6pfed2:

• d6pfed2 first appeared in SCOPe 2.07