SCOPe 2.08: Domain d6df6a_: 6df6 A:

Lineage for d6df6a_ (6df6 A:)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Estrogen receptor alpha [48519] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48520] (107 PDB entries)
   Uniprot P03372 307-551

8. Domain d6df6a_: 6df6 A: [365021]
   automated match to d3q95b_
   complexed with g8y, gol

Details for d6df6a_

PDB Entry: 6df6, 2.5 Å

PDB Description: crystal structure of estrogen receptor alpha in complex with receptor degrader 16ab

PDB Compounds: (A:) Estrogen receptor

SCOPe Domain Sequences for d6df6a_:

Sequence, based on SEQRES records:

>d6df6a_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitdt
lihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpsydlllemld
a

Sequence, based on observed residues (ATOM records):

>d6df6a_ a.123.1.1 (A:) Estrogen receptor alpha {Human (Homo sapiens) [TaxId: 9606]}
lalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrvp
gfvdltshdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveif
dmllatssrfrmmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtli
hlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmvvpsydlllemlda

Timeline for d6df6a_:

• d6df6a_ first appeared in SCOPe 2.07