Lineage for Family a.123.1.1: Nuclear receptor ligand-binding domain

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2335122Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
    multihelical; 3 layers or orthogonally packed helices
  4. 2335123Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families) (S)
  5. 2335124Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 protein domains)

Protein Domains:

  1. 2335125Androgen receptor [63621] (4 species)
    1. 2335126Species Chimpanzee (Pan troglodytes) [TaxId:9598] [109986] (8 PDB entries)
      Uniprot O97775 661-910 # 100% sequence identity to human sequence (Uniprot P10275 669-918)
    2. 2335135Species Human (Homo sapiens) [TaxId:9606] [63623] (65 PDB entries)
      Uniprot P10275 671-919
    3. 2335203Species Mouse (Mus musculus) [TaxId:10090] [187213] (1 PDB entry)
    4. 2335205Species Norway rat (Rattus norvegicus) [TaxId:10116] [63622] (6 PDB entries)
  2. 2335212Bile acid receptor FXR [101433] (2 species)
    1. 2335213Species Human (Homo sapiens) [TaxId:9606] [101434] (8 PDB entries)
    2. 2335223Species Norway rat (Rattus norvegicus) [TaxId:10116] [101435] (2 PDB entries)
  3. 2335228Ecdysone receptor [101436] (1 species)
  4. 2335233Estrogen receptor alpha [48519] (1 species)
  5. 2335387Estrogen receptor beta [48521] (2 species)
    1. 2335388Species Human (Homo sapiens) [TaxId:9606] [48522] (27 PDB entries)
    2. 2335441Species Norway rat (Rattus norvegicus) [TaxId:10116] [48523] (2 PDB entries)
  6. 2335444Glucocorticoid receptor [89140] (1 species)
  7. 2335458Hepatocyte nuclear factor 4-alpha [109605] (2 species)
    1. 2335459Species Human (Homo sapiens) [TaxId:9606] [109987] (1 PDB entry)
      Uniprot P41235 139-369
    2. 2335461Species Norway rat (Rattus norvegicus) [TaxId:10116] [89146] (1 PDB entry)
  8. 2335466Hepatocyte nuclear factor 4-gamma [81918] (1 species)
  9. 2335469Nuclear hormone receptor HR38 [89144] (1 species)
  10. 2335473Orphan nuclear receptor ERR3 [81916] (1 species)
  11. 2335509Orphan nuclear receptor NR1I3 (CAR) [117014] (2 species)
    1. 2335510Species Human (Homo sapiens) [TaxId:9606] [117016] (2 PDB entries)
      Uniprot Q14994 103-352
    2. 2335515Species Mouse (Mus musculus) [TaxId:10090] [117015] (2 PDB entries)
      Uniprot O35627 109-358
  12. 2335522Orphan nuclear receptor NR4A1 [158811] (1 species)
  13. 2335556Orphan nuclear receptor NR5a2 (LRH-1) [89147] (1 species)
  14. 2335562Orphan nuclear receptor NURR1 [89142] (1 species)
  15. 2335570Orphan nuclear receptor ROR-alpha [81914] (1 species)
  16. 2335574Orphan nuclear receptor ROR-beta [74794] (1 species)
  17. 2335579Oxysterols receptor LXR-alpha [109988] (2 species)
    1. 2335580Species Human (Homo sapiens) [TaxId:9606] [109989] (1 PDB entry)
      Uniprot Q13133 207-445
    2. 2335582Species Mouse (Mus musculus) [TaxId:10090] [158810] (2 PDB entries)
      Uniprot Q9Z0Y9 203-443
  18. 2335589Oxysterols receptor LXR-beta [89149] (1 species)
  19. 2335607Peroxisome proliferator activated receptor alpha, PPAR-alpha [69109] (1 species)
  20. 2335636Peroxisome proliferator activated receptor gamma, PPAR-gamma [48524] (1 species)
  21. 2335843Peroxisome proliferator-activated receptor delta, PPAR-DELTA [48526] (1 species)
  22. 2335908Pregnane x receptor, PXR [63624] (1 species)
  23. 2335931Progesterone receptor [48517] (1 species)
  24. 2335951Retinoic acid receptor alpha (RAR-alpha) [48513] (1 species)
  25. 2335955Retinoic acid receptor beta (RAR-beta) [117011] (2 species)
    1. 2335956Species Human (Homo sapiens) [TaxId:9606] [117013] (2 PDB entries)
      Uniprot P10826 182-416
    2. 2335960Species Mouse (Mus musculus) [TaxId:10090] [117012] (1 PDB entry)
      Uniprot P22605 209-453
  26. 2335963Retinoic acid receptor gamma (RAR-gamma) [48515] (1 species)
  27. 2335974Retinoid-X receptor alpha (RXR-alpha) [48510] (2 species)
    1. 2335975Species Human (Homo sapiens) [TaxId:9606] [48511] (35 PDB entries)
      Uniprot P19793 227-458
    2. 2336039Species Mouse (Mus musculus) [TaxId:10090] [48512] (3 PDB entries)
      Uniprot P28700 232-463
  28. 2336044Retinoid-X receptor beta (RXR-beta) [74792] (1 species)
  29. 2336051Steroid hormone receptor ERR1 [109990] (1 species)
  30. 2336058Thyroid hormone receptor alpha1 (TR-alpha1) [48532] (1 species)
  31. 2336065Thyroid hormone receptor beta (TR-beta) [48530] (1 species)
  32. 2336086Ultraspiracle protein, usp [48534] (2 species)
    the ortholog of RXRs in insects
    1. 2336087Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [48535] (1 PDB entry)
    2. 2336094Species Tobacco budworm (Heliothis virescens) [TaxId:7102] [63626] (4 PDB entries)
  33. 2336099Vitamin D nuclear receptor [48528] (2 species)
    1. 2336100Species Human (Homo sapiens) [TaxId:9606] [48529] (30 PDB entries)
    2. 2336128Species Norway rat (Rattus norvegicus) [TaxId:10116] [101432] (25 PDB entries)
  34. 2336144automated matches [190059] (14 species)
    not a true protein
    1. 2336145Species Ancestral gene [230150] (1 PDB entry)
    2. 2336147Species Artificial gene [TaxId:32630] [189856] (1 PDB entry)
    3. 2336150Species Bemisia tabaci [TaxId:7038] [255003] (1 PDB entry)
    4. 2336152Species Biomphalaria glabrata [TaxId:6526] [188120] (1 PDB entry)
    5. 2336155Species Branchiostoma floridae [TaxId:7739] [188654] (1 PDB entry)
    6. 2336160Species Chicken (Gallus gallus) [TaxId:9031] [195567] (1 PDB entry)
    7. 2336162Species Cotton bollworm (Helicoverpa armigera) [TaxId:29058] [189564] (1 PDB entry)
    8. 2336164Species Escherichia coli [TaxId:469008] [189841] (1 PDB entry)
    9. 2336166Species Human (Homo sapiens) [TaxId:9606] [187214] (157 PDB entries)
    10. 2336429Species Mouse (Mus musculus) [TaxId:10090] [189464] (4 PDB entries)
    11. 2336435Species Norway rat (Rattus norvegicus) [TaxId:10116] [187147] (4 PDB entries)
    12. 2336440Species Pediculus humanus [TaxId:121224] [258056] (2 PDB entries)
    13. 2336444Species Tobacco budworm (Heliothis virescens) [TaxId:7102] [187215] (1 PDB entry)
    14. 2336446Species Tribolium castaneum [TaxId:7070] [188215] (1 PDB entry)

More info for Family a.123.1.1: Nuclear receptor ligand-binding domain

Timeline for Family a.123.1.1: Nuclear receptor ligand-binding domain: