SCOPe 2.06: Domain d5op4a_: 5op4 A:

Lineage for d5op4a_ (5op4 A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (17 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (653 PDB entries)

8. Domain d5op4a_: 5op4 A: [340583]
   automated match to d2ydia_
   complexed with a0t; mutant

Details for d5op4a_

PDB Entry: 5op4, 2 Å

PDB Description: structure of chk1 10-pt. mutant complex with aminopyrimidine lrrk2 inhibitor

PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d5op4a_:

Sequence, based on SEQRES records:

>d5op4a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicilkml
nhenvikfyghrregniqylfmelasggslfdriepdigmpepdaqrffhqlmagvvylh
gigithrdikphnlllderdnlkiadyslatvfrynnrerllnkmcgtlpyvapellkrr
efhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplall
hkilvenpsaritipdikkdrwynkplk

Sequence, based on observed residues (ATOM records):

>d5op4a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vpfvedwdlvqtlgegaygevqlavnrvteeavavkivdnikkeicilkmlnhenvikfy
ghrregniqylfmelasggslfdriepdigmpepdaqrffhqlmagvvylhgigithrdi
kphnlllderdnlkiadyslatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdv
wscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenps
aritipdikkdrwynkplk

Timeline for d5op4a_:

• d5op4a_ is new in SCOPe 2.06-stable
  
• d5op4a_ appears in SCOPe 2.07
  
• d5op4a_ appears in the current release, SCOPe 2.08